ABSTRACT
A family with five ovarian neoplasms in three subsequent generations was studied. Four women had ovarian cancer at age 38, 40, 47, and 53, and one had cystoma ovari at 24. There were other neoplasms and preneoplastic lesions in this family. Several developmental anomalies were revealed, and one of them (a tooth anomaly) may be associated with ovarian tumors. Cytogenetic studies have been carried out on six of the living relatives, including two treated for ovarian neoplasms. The incidence of spontaneous chromosome aberrations was not significantly increased in each of these cases. Polymorphism of constitutive heterochromatin regions was observed in all six individuals. The possible type of inheritance of the ovarian cancer, the significance of the tooth anomaly, and the constitutive heterochromatin polymorphism as cancer markers in this family are discussed.
Subject(s)
Carcinoma/genetics , Ovarian Neoplasms/genetics , Chromosome Banding , Female , Humans , Incisor/abnormalities , Karyotyping , Ovarian Neoplasms/complications , Pedigree , Tooth Abnormalities/complicationsSubject(s)
Granulosa Cell Tumor/therapy , Ovarian Neoplasms/therapy , Thecoma/therapy , Female , Granulosa Cell Tumor/mortality , Humans , Leydig Cell Tumor/mortality , Leydig Cell Tumor/therapy , Neoplasm Staging , Ovarian Neoplasms/mortality , Postoperative Care , Sertoli Cell Tumor/mortality , Sertoli Cell Tumor/therapy , Sertoli-Leydig Cell Tumor/mortality , Sertoli-Leydig Cell Tumor/therapy , Thecoma/mortalitySubject(s)
Brenner Tumor/diagnosis , Ovarian Neoplasms/diagnosis , Adult , Aged , Brenner Tumor/therapy , Female , Humans , Middle Aged , Ovarian Neoplasms/therapyABSTRACT
401 cases of hormone-producing tumors of the ovary were studied (190 theca-cell, 169--granulose cell, 25--mixed thecagranulosa cell and 17--virilising tumors). Histological diagnosis, clinical stage and end results of their treatment were compared. Theca-granulosa cell tumor is considered to be the most malignant form of these neoplasms. Pure theca-cell tumor proved to be benign in most cases. Of special interest is a high percentage of patients being cured at stage 1 (FIGO classification) of neoplastic process, that stands, in the authors' opinion, in close relationship with comparatively good results obtained in these patients.
Subject(s)
Adenoma/pathology , Granulosa Cell Tumor/pathology , Ovarian Neoplasms/pathology , Sertoli-Leydig Cell Tumor/pathology , Thecoma/pathology , Adenoma/mortality , Female , Granulosa Cell Tumor/mortality , Humans , Neoplasm Staging , Ovarian Neoplasms/mortality , Sertoli-Leydig Cell Tumor/mortality , Thecoma/mortalitySubject(s)
Carcinoma/pathology , Ovarian Neoplasms/pathology , Biopsy , Carcinoma/surgery , Female , Humans , Laparotomy , Neoplasm Staging , Ovarian Neoplasms/surgerySubject(s)
Chromosome Aberrations/pathology , Chromosomes, Human, 16-18/ultrastructure , Chromosomes, Human, 19-20/ultrastructure , Chromosomes, Human, 21-22 and Y/ultrastructure , Chromosomes, Human, 6-12 and X/ultrastructure , Ovarian Neoplasms/ultrastructure , Chromosome Disorders , Diploidy , Female , Genetic Markers , Humans , Karyometry , Polyploidy , Staining and Labeling/methodsABSTRACT
Two families with high incidence of ovarian cancer among the 1st and 2nd degree relatives are described. These were four sisters suffering it in one family (K). In the other family (L) but the proband her mother and two mother's sisters had ovarian cancer. A daughter of the proband at the age of 24 had surgically removed cystoma of the left ovary. In this family in all women with ovarian tumors as well as in their other two relatives congenital teeth anomalies were observed.
