ABSTRACT
In a double-blind, single dose study of analgesic efficacy, 202 patients who had undergone lower 3rd molar extraction were divided into 5 groups to receive aspirin, placebo, ibuprofen, codeine, or an ibuprofen/codeine combination. Ibuprofen 200 mg (with or without codeine phosphate 15 mg) and aspirin 600 mg were significantly superior to either placebo or codeine phosphate 15 mg alone. Codeine phosphate at a dose of 15 mg was ineffective as an analgesic either alone or in combination.
Subject(s)
Codeine/administration & dosage , Ibuprofen/administration & dosage , Pain, Postoperative/drug therapy , Adolescent , Adult , Aspirin/therapeutic use , Clinical Trials as Topic , Double-Blind Method , Drug Combinations , Humans , Random Allocation , Time Factors , Tooth Extraction/adverse effectsSubject(s)
Back Pain/drug therapy , Circadian Rhythm , Ibuprofen/administration & dosage , Adolescent , Adult , Aged , Drug Administration Schedule , Female , Humans , Ibuprofen/therapeutic use , Male , Middle AgedABSTRACT
In a double-blind, single dose study of analgesic efficacy, 165 patients who were expected to develop moderate to severe pain following the removal of an impacted mandibular third molar tooth were allocated to receive aspirin, placebo, or an increasing dose of a fixed ratio ibuprofen/codeine combination. The degree of pain experienced prior to medication was noted and the patients were asked to record the degree of pain and of pain relief hourly for the following 5 hours. The study produced clear evidence of the superior efficacy of the combinations when compared to placebo and aspirin. In addition, the high dose combination appeared to be superior with respect to pain relief and the need for additional analgesia compared to the low dose treatment. There were few side effects and only one severe reaction was reported by a patient in the high dose group. To avoid side effects it is suggested that the medium-dose combination, ibuprofen 400 mg/codeine 30 mg, is optimal.
Subject(s)
Aspirin/therapeutic use , Codeine/therapeutic use , Ibuprofen/therapeutic use , Pain, Postoperative/drug therapy , Tooth Extraction/adverse effects , Clinical Trials as Topic , Codeine/administration & dosage , Double-Blind Method , Drug Combinations , Humans , Ibuprofen/administration & dosage , Molar, Third/surgery , Random Allocation , Time Factors , Tooth, Impacted/surgeryABSTRACT
In a study of 144 patients, with Grade 1 and 2 inversion injuries to the ankle sustained in sport, treatment with a non-steroidal anti-inflammatory was considerably superior to placebo with respect to joint tenderness, level of training and injury severity. No difference in efficacy could be determined between ibuprofen 2400 mg given in two or four equally divided daily doses. Ten patients withdrew from the study because of side effects, five from ibuprofen twice daily, three from ibuprofen four times daily and two from the placebo group. This study confirms the efficacy, flexibility and tolerability of high dose ibuprofen.
Subject(s)
Ankle Injuries , Athletic Injuries/drug therapy , Ibuprofen/therapeutic use , Sprains and Strains/drug therapy , Adult , Clinical Trials as Topic , Double-Blind Method , Drug Administration Schedule , Female , Humans , Ibuprofen/adverse effects , Ligaments, Articular/injuries , Male , Random AllocationABSTRACT
In a double-blind, single-dose study, the analgesic effect of a combined ibuprofen-codeine phosphate preparation was compared with those of zomepirac and placebo in 127 patients with moderate or severe postepisiotomy pain. Both the combination and zomepirac were significantly more effective than placebo for up to six hours, but the onset of action of the combination was more rapid than that of zomepirac. The study was notable for the virtual absence of side effects.
Subject(s)
Codeine/analogs & derivatives , Episiotomy , Ibuprofen/therapeutic use , Pain, Postoperative/drug therapy , Pyrroles/therapeutic use , Tolmetin/therapeutic use , Adult , Clinical Trials as Topic , Codeine/adverse effects , Codeine/therapeutic use , Double-Blind Method , Drug Combinations , Female , Humans , Ibuprofen/adverse effects , Random Allocation , Time Factors , Tolmetin/adverse effects , Tolmetin/analogs & derivativesABSTRACT
In a double-blind single-dose study, the analgesic effect of a new ibuprofen-codeine phosphate combination was compared with those of codeine phosphate alone and placebo for the relief of moderate and severe postepisiotomy pain. In the 113 patients studied, combination therapy was superior to codeine phosphate alone and to placebo, the difference between the combination and codeine phosphate alone reaching statistical significance (P less than 0.05) after two hours. The few side effects reported were not of a serious nature.
Subject(s)
Codeine/therapeutic use , Pain, Postoperative/drug therapy , Clinical Trials as Topic , Codeine/administration & dosage , Codeine/adverse effects , Double-Blind Method , Episiotomy , Female , Humans , Pregnancy , Random AllocationABSTRACT
An open, multi-centre study in general practice was carried out in 1842 patients presenting with non-serious painful conditions to assess the effectiveness and tolerance of ibuprofen. Patients received daily doses ranging from 400 mg to 2400 mg for up to 1 month; most took between 1200 mg and 1600 mg per day for about 1 week. Assessments of pain severity on a visual analogue scale showed that 82% of patients with moderate to severe pain derived benefit from treatment, the analgesic effect of a dose often lasting up to 6 hours. The best response was seen in patients with dysmenorrhoea and dental pain, and although headache was less responsive than other painful conditions the overall rate of positive results for this diagnosis reached 75% in the opinion of both physicians and patients. Approximately 14% of patients reported side-effects, mostly gastro-intestinal with abdominal pain predominating.
