ABSTRACT
PURPOSE: This study evaluated whether the presence of the salivary acquired pellicle (AP) had any effect on the dentin's darkening and on the caries arresting effect after the use of SDF + KI, in a cariogenic challenge. METHODS: Human dentin specimens were standardised, submitted to artificial caries lesion formation, and divided into five groups (n = 20): C: control group-no treatment, SDF: 38% SDF, APSDF: SDF 38% and AP, KISDF: 38% SDF and KI, and APKISDF: 38% SDF, KI and AP, that were submitted to pH cycling. Colour evaluation (CIE L*a*b* system) and surface hardness were performed before and after the treatments/pH cycling. RESULTS: SDF and APSDF groups showed no difference in colour. KISDF and APKISDF groups showed significantly different colours than the groups without KI. SDF, APSDF, and APKISDF groups had less mineral loss than C and KISDF. SDF, APSDF, and APKISDF revealed significantly greater mineral recovery, compared to KISDF and C. CONCLUSION: The AP did not influence the dentin´s colour after SDF + KI, but had a protective role in modulating the dentin´s mineral gain/loss. KI used after SDF decreased the dentin´s darkening, and did not interfere with the dentin de/remineralization process.
Subject(s)
Dental Caries , Potassium Iodide , Humans , Dental Pellicle/pathology , Color , Dentin , Fluorides, Topical/pharmacology , Dental Caries/prevention & control , MineralsABSTRACT
O sangramento por doença diverticular é uma causa comum de hemorragia digestiva baixa. Os pacientes geralmente apresentam-se com hemorragia maciça e indolor. Se o sangramento apresentar repercussão hemodinâmica, medidas como manutenção das vias aéreas, ressuscitação volêmica, seguidas da medição dos níveis de hemoglobina, hematócrito e tipagem sanguínea com reações cruzadas devem ser instituídas de imediato. Em casos de instabilidade hemodinâmica, a transfusão de hemoderivados não deve ser postergada. Porém quadros dramáticos são mais raros, já que a maioria resolve-se espontaneamente em cerca de 80% das vezes. O exame diagnóstico inicial recomendado é a colonoscopia, realizada idealmente dentro de 12 a 48 horas do início do quadro e após um rápido preparo colônico; se a fonte do sangramento for identificada, manobras terapêuticas endoscópicas poderão ser executadas.
Subject(s)
Humans , Male , Aged , Diverticulitis, Colonic , Gastrointestinal HemorrhageABSTRACT
AIM: To assess the effect of sibutramine-assisted weight reduction program on insulin sensitivity and metabolic parameters in obese normal glucose tolerant individuals over a period of 24 weeks. RESEARCH DESIGN AND METHODS: A double-blind, placebo-controlled, parallel, prospective clinical trial was carried out at our medical centre. Forty female normal glucose tolerant patients, body mass index: 34.3 +/- 2.9 kg/m2 and age: 41.1 +/- 9.9 (range: 19-58 years), were randomized to placebo or sibutramine, 10 mg once daily. RESULTS: Seventeen patients from sibutramine group and 14 placebo had completed the study protocol. Significant weight change was seen in sibutramine (p < 0.01) (-5.6 kg or -6.1% vs. +0.9 kg or +1.1% in placebo). Insulin sensitivity enhanced in sibutramine group (Kitt: from 4.03 +/- 1.97 to 5.09 +/- 2.48%/min; p < 0.05). Homeostasis model assessment-IR (HOMA-IR) decreased from 7.8 +/- 6.9 to 5.6 +/- 4.5 (p < 0.05). HOMA-beta also decreased from 508 +/- 381 to 374 +/- 256 (p < 0.05). No changes were observed in the placebo control group regarding insulin sensitivity or secretion. Concomitant reductions were observed in the sibutramine group in lipid parameters (triglycerides and high-density lipoprotein-cholesterol), uric acid and gamma-glutamyl transferase (p < 0.05). CONCLUSIONS: Sibutramine has demonstrated efficacy in reducing weight in non-diabetic women along with amelioration in insulin sensitivity and additional improvement in metabolic parameters.
