1.
Chem Commun (Camb)
; 51(51): 10330-3, 2015 Jun 28.
Article
in English
| MEDLINE
| ID: mdl-26027845
ABSTRACT
Bioorthogonal click ligations are extensively used for the introduction of functional groups in biological systems. Tetrazine ligations are attractive in that they are catalyst-free and display favorable kinetics. We describe the efficient remodeling of bacterial cell surfaces using unnatural d-amino acids derivatized with tetrazine ligation handles. The metabolic incorporation of these unnatural d-amino acids onto bacterial cell surfaces resulted in a site-selective installation of fluorophores.