[The effect of carbon disulphide on menopause, concentration of monoamines, gonadotropins, estrogens and androgens in women]. / Wplyw dwusiarczku wegla na wystepowanie przekwitania, stezenie monoamin, gonadotropin, estrogenów i androgenów u kobiet.

The clinical examinations covered 1710 women. The investigations were performed on 199 women with symptoms of menopause, who were selected and divided into two groups. The first control group (I) included 80 women employed in the Industrial Clothing Factory "Dana" in Szczecin, without contact with carbon disulphide. The second study group (II) comprised 119 women employed in the Synthetic Fibres Factory "Chemitex-Wiskord" and exposed chronically to carbon disulphide in concentration of 9.36-23.4 mg/m3. The microclimate conditions of the production halls in both groups were similar (Tab. 1). Menopause was present in 16.59% of women in the population chronically exposed to carbon disulphide, as compared with 8.05% in the normal population. Mean age at menopause in women of the first group was 48.1 years and 43.9 years in the second group. In the studied group of menopausal women retrospective estimation of menopausal and gestational cycles shows statistically significant increase in abortion and disorders of menstrual cycles (p < 0.001) (Tab. 2). The women chronically exposed to CS2 had significantly more frequently headaches, weight gain and loss of libido (p < 0.001). In the normal group fatigue, palpitations and hot flushes were found significantly more often (p < 0.001) (Tab. 4). The serum concentrations of estrone (p < 0.01), estradiol, progesterone, 17-hydroxyprogesterone were significantly decreased in women chronically exposed to CS2 (p < 0.001). No significant differences in the level of FSH or LH were noted between both groups (Tab. 3). The daily excretion of adrenaline and noradrenaline in urine concentrations of dopamine in plasma of women chronically exposed to CS2, was significantly lower (p < 0.001), but the serum concentrations of serotonin (Tab. 5), testosterone, dehydroepiandrosterone sulphate (DHAS) and prolactin in plasma were significantly higher (p < 0.001). No difference concerning the level in serum of dehydroepiandrosterone and beta-endorfine was found (Tab. 6). Significant negative linear correlations between serotonin and FSH (r = -0.45; p < 0.001), serotonin and daily excretion of adrenaline (r = -0.43; p < 0.01) or noradrenaline (r = -0.58; p < 0.001) were disclosed in the exposed group. In this group a positive correlation was noted between the concentration of serotonin and prolactin (r = 0.45; p < 0.001).

[The linear correlation coefficient of serotonin and prolactin concentrations in plasma of women chronically exposed to carbon disulfide]. / Wspólczynniki korelacji liniowej miedzy stezeniem serotoniny i prolaktyny u kobiet w okresie przekwitania, narazonych na przewlekle dzialanie dwusiarczku wegla.

A group of 70 women, examined clinically, was divided into two even subgroups: subgroup I--controls, aged 49.8 +/- 3.2 years, non-exposed to carbon disulfide (CS2), and subgroup II, aged 43.6 +/- 1.7 years chronically exposed to CS2 in concentration of 9.36--23.4 mg/m3. The concentration of CS2 was measured using Mc Cammon's method, concentration of serotonin in plasma by employing the colorimetric method according to Manuchin and the radioimmunological method was applied in measuring the prolactin concentration. Student-t test and Pearson's linear correlation coefficient "C" were used for the statistical analysis. It was found that in women exposed to CS2 serotonin and prolactin concentrations were significantly higher (p < 0.001). The linear correlation between serotonin and prolactin concentrations was also significantly positive (r = 0.44; p 0.01) in women expose to carbon disulfide.

[Evaluation of the relationship between concentration of serotonin in plasma and blood platelets and hypertension in women chronically exposed to carbon disulfide]. / Ocena zaleznosci miedzy stezeniem serotoniny w osoczu i w plytkach krwi a cisnieniem tetniczym krwi u kobiet narazonych na przewlekle dzialanie dwusiarczku wegla.

Totally 140 women, aged 25-50 years, were examined clinically. They were divided into two groups. Group I, the controls, (n - 50; mean age 40.1 +/- 8.7) not exposed to carbon disulfide, and Group II (n = 90; mean age 39.7 +/- 9.1) exposed to carbon disulphide at concentration of 9.36-23.4 mg/m3. Concentration of serotonin in plasma and blood platelets was determined using Manuchin's colorimetric method. Student t-test and the Pearson linear correlation coefficient "C" were used for statistical analysis. It was found that women chronically exposed to carbon disulfide showed significantly higher values of serotonin concentration in plasma and thrombocytes (p < 0.001) that the controls. Also positive linear correlation was noted between concentration of serotonin and hypertension in women exposed to CS2.

[Concentration of dihydroepiandrosterone, dihydroepiandrosterone sulphate and testosterone during premature menopause in women chronically exposed to carbon disulfide]. / Stzenie dwuhydroepiandrosteronu (DHA), siarczanu dwuhydroepiandrosteronu (DHAS) i testosteronu w surowicy u kobiet w okresie przekwitania, narazonych na przewlekle dzialanie dwusiarczku wegla.

The authors examined clinically 1710 women. They were split into two groups depending on the type of work performed. Group I (mean age = 37.3 years; average employment period = 26.2 years) was not exposed to carbon disulfide. The incidence of premature menopause in this group was 8.05%. Group II (n = 717; mean age = 38.3 years; average employment period = 25.6 years) was exposed to CS2 concentration in the air ranging from 9.36 to 23.4 mg/m3. In this group 119 women (16.5%) showed symptoms of premature menopause. Concentration of androgens in serum was determined using radioimmunoassay. It was found that women chronically exposed to carbon disulfide had significantly lowered values for dihydroepiandrosterone sulphate (p < 0.001), total testosterone (p < 0.01) and free testosterone (p < 0.01) when compared with the controls. No difference was found in the concentration of dihydroepiandrosterone.

Concentration of dopamine in plasma, activity of dopamine beta-hydroxylase in serum and urinary excretion of free catecholamines and vanillylmandelic acid in women chronically exposed to carbon disulphide.

The authors studied 140 women, selected at random, aged 22-55, divided into two groups. Group I (control) included 50 women, mean age 40.1 +/- 1.7 years. Group II included 90 women, mean age 39.7 +/- 2.1 years, chronically exposed to 15.6 - 21.84 mg/m3 of carbon disulphide from 0.5 to over 20 years. It was found that women chronically exposed to CS2 showed significantly lower levels of dopamine and lower activities of DBH (p < 0.001), significantly lower urinary excretion of adrenaline (p < 0.001), but insignificantly lower excretion of noradrenaline and vanillylmandelic acid.

[Effect of carbon disulfide on menopause in women]. / Wplyw dwusiarczku wegla na wystepowanie przekwitania u kobiet.

The authors examined clinically 1710 women. Among them 199 women with symptoms of menopause were selected and divided into two groups: group I (control) included 80 women without contact with carbon disulphide and group II (examined) included 119 women chronically exposed to carbon disulphide at a concentration of 9.36-23.4 mg/m3. Menopause was present in 16.59% of women chronically exposed to CS2 as compared with 8.05% of the normal population. The mean age at menopause was 48.1 years in group I and 43.9 in group II. Significantly more frequent headaches, weight gain and loss of libido (p < 0.01) were observed in women chronically exposed to CS2. While in the control group fatigue, palpitations and hot flushes were more often (p < 0.001). The concentrations of estrone (p < 0.01), estradiol, progesterone, 17-hydroxy-progesterone, testosterone and dehydroepiandrosterone sulphate (DHAS) were significantly decreased in women chronically exposed to CS2 (p < 0.001). No difference in the level of dehydroepiandrosterone was found. The daily excretion of adrenaline and noradrenaline in urine and concentrations of dopamine in plasma of women chronically exposed to CS2 were lower (p < 0.001), while the concentrations of serotonin and prolactin in plasma were higher (p < 0.001). No differences in the level of FSH or LH were noted between the two groups. Significant negative linear correlations between serotonin and FSH (r = -0.45; p < 0.01) serotonin and daily excretion of adrenalin (r = -0.43; p < 0.01) or noradrenalin (r = -0.58; p < 0.001) were found in the exposed group.(ABSTRACT TRUNCATED AT 250 WORDS)