1.
FEMS Yeast Res
; 13(7): 682-8, 2013 Nov.
Article
in English
| MEDLINE
| ID: mdl-23875998
ABSTRACT
The tumor suppressor p53 plays a central role in the regulation of cellular growth and apoptosis. In the yeast Saccharomyces cerevisiae, the overexpression of the human p53 leads to growth inhibition and apoptotic cell death on minimal medium. In the present work, we show that p53-expressing cells are more susceptible to cell death after an apoptotic stimulus such as H2O2. The analysis of mutants involved in yeast apoptosis-like death suggests that the observed cell death is Yca1 independent and mainly mediated through Nuc1p.
Subject(s)
Apoptosis , Endonucleases/metabolism , Exonucleases/metabolism , Saccharomyces cerevisiae Proteins/metabolism , Saccharomyces cerevisiae/drug effects , Saccharomyces cerevisiae/metabolism , Signal Transduction , Tumor Suppressor Protein p53/metabolism , Caspases/metabolism , Culture Media/chemistry , Gene Expression , Humans , Hydrogen Peroxide/toxicity , Saccharomyces cerevisiae/genetics
2.
Drug-induced inhibition of tubulin polymerization induces mitochondrion-mediated apoptosis in yeast.
Cell Cycle
; 10(18): 3208-9, 2011 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-21912212