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5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa.
Batt, Douglas G; Qiao, Jennifer X; Modi, Dilip P; Houghton, Gregory C; Pierson, Deborah A; Rossi, Karen A; Luettgen, Joseph M; Knabb, Robert M; Jadhav, P K; Wexler, Ruth R.
Bioorg Med Chem Lett ; 14(21): 5269-73, 2004 Nov 01.
Article in English | MEDLINE | ID: mdl-15454209

ABSTRACT

Structural features of a 5-amidinoindole inhibitor of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa.


Subject(s)
Factor IXa/antagonists & inhibitors , Factor IXa/chemistry , Factor Xa Inhibitors , Factor Xa/chemistry , Indoles/chemical synthesis , Indoles/chemistry , Models, Molecular , Stereoisomerism , Structure-Activity Relationship , Substrate Specificity
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