ABSTRACT
Atypical fibroxanthoma is a cutaneous soft tissue tumor that may mimic squamous cell carcinoma and melanoma on clinical and histologic examination. Immunohistochemical stains for cytokeratin, S100 protein, and vimentin may be helpful in differentiating atypical fibroxanthoma from the latter two diagnoses. We report a patient with atypical fibroxanthoma of the cheek who underwent successful local excision. The clinical and laboratory features of this neoplasm are reviewed.
Subject(s)
Cheek/pathology , Facial Neoplasms/pathology , Fibroma/pathology , Skin Neoplasms/pathology , Aged , Aged, 80 and over , Diagnosis, Differential , Humans , Male , Vimentin/analysisABSTRACT
A 70-year-old man with a history of hereditary hemorrhagic telangiectasis was found to have occult blood in his stool after a routine physical examination. Endoscopic evaluation revealed a small, sessile tumor that was consistent with well-differentiated adenocarcinoma of the sigmoid colon on histologic examination.
Subject(s)
Adenocarcinoma/complications , Sigmoid Neoplasms/complications , Telangiectasia, Hereditary Hemorrhagic/complications , Adenocarcinoma/pathology , Aged , Humans , Male , Occult Blood , Sigmoid Neoplasms/pathology , Telangiectasia, Hereditary Hemorrhagic/pathologyABSTRACT
The effect of poly-L-lysine and polyglycols on the electronic spectral properties of cobalt-tetracarboxy-phthalocyanine, compound (I), was studied in order to determine the effect of the polymers on the molecular stacking properties of compound (I). In the present study we have coupled, both covalently and electrostatically, the poly-L-lysine to compound (I). The electrostatic interaction with the polylysine resulted in a bathochromic shift of absorbance by compound (I) from 680 to 695 nm, and the generation of shoulders in the 590 and 580 nm region. The bathochromic shift indicates that the polylysine either misaligns the units of compound (I) in the molecular stack or alters the angular relationship of the planar compound (I) molecules. The covalent linkage with the polylysine resulted in stabilization of the monomeric form of compound (I) with no hypochromism in the 680 nm region. The reaction of the polyglycols, dextran and DEAE dextran with compound (I) prior to the addition of the polylysine, stabilized the polymeric stacked form of compound (I) in the presence of the polylysine. Ammonium ion and ethanolamine resulted in the appearance of peaks in the 730-760 nm region; a trihydroxy containing primary amine and monomeric lysine generated no such peak at wavelengths above 700 nm. The polyglycol binding capacity of compound (I) facilitated the separation of the unbound compound (I) from the polymeric complexes.
