[Toxoplasmosis in families. I. Detection of T. gondii invasion and serological appraisal]. / Toksoplazmoza srodowisk rodzinnych. I Wykrywanie inwazji i ocena serologiczna.

Toxoplasmosis was studied in 102 families, in which index-cases manifested the fully symptomatic course of the acquired lymphnodular toxoplasmosis, confirmed by presence of IgM and IgG class antibodies (ELISA, Vidas, BioMerieux). The index-cases (group A) provided a rational index of the acquired invasion or its late sequele in other families members. The studies were performed in 388 persons, originating from Wielkopolska region, including 102 patients of a group A and 286 of families members of group B (167 children and 221 adults). In group A patients (including 49 children and 53 adults) immunoserological studies detected IgM class antibodies in 68.7% of cases and IgG class antibodies in 94.1% patients. In 286 family members (group B), presence of IgM class antibodies was found in 12.2% and IgG class antibodies was found in 55.2% studied persons; clinical pathology was noted in 46 patients (16.3%) including 3 pregnant women. The obtained results point to the need of complex evaluation of family environments based on analysis of serological tests (including estimation of IgM and IgG class antibodies) and accompanied by clinical analysis of studied children and adults.

[Toxoplasmosis in families. II. Clinical analysis]. / Toksoplazmoza srodowisk rodzinnych. II. Analiza kliniczna.

Clinical and serological analysis was conducted on 102 families including index-cases of lymphonodular toxoplasmosis (102 patients-group A) and 286 family members (group B). The studies included a total of 388 persons (167 children and 221 adults), originating mainly from Wielkopolska region (West Poland). The lymphonodular form of toxoplasmosis represented the dominating pattern among adult cases but among children the clinical pathology pattern was variable: in 14 out of 49 children (group A) lymphadenopathy was not dominating sign and clinically signs and symptoms of central nervous system or organ of vision involvement prevailed; in 6 cases clinical pattern pointed to congenital toxoplasmosis and in 8 cases it indicated sequele of acquired toxoplasmosis. In group B, among 35 children with lymphadenopathy, 7 presented also neurological signs/symptoms, in 5 children the pattern suggested acquired neurotoxoplasmosis in 2 cases congenital form of toxoplasmosis. In 11 adults of the group, lymphonodular form of the disease was diagnosed. In both groups (A and B), the pattern lymphonodular toxoplasmosis was detected also in 5 pregnant women (1.3% of studied persons and 2.7% of all adults). Four of the pregnant women manifested active stage of the disease, confirmed by the presence of IgM class antibodies. Thus, among 286 family members clinical pathology was demonstrated in 46 patients (16.1%) and in 35 patients (12.2%) activity of the disease presented indications for a specialistic therapy.

Detection of Trichinella SP. invasion and clinical appraisal of patients in the late stage of trichinellosis in a new epidemic focus in Wielkopolska.

A clinical and an epidemiological analysis was presented of a trichinellosis focus from Wielkopolska region. The studies included 20 persons and trichinellosis was diagnosed in 15 cases. The focus was characterized by asynchronous invasion with Trichinella sp. in individual affected persons in the course of a prolonged period (around 2.5 months) and by reporting of the patients to the Clinic during approximately 30 to 90 days after the disease signs/symptoms developed. Retrospective analysis and a set of specialized tests permitted to clarify causes of persisting complaints, presented by the patients, as well as to establish the diagnosis at late stages of trichinellosis.