ABSTRACT
Confocal microscopy with in vivo and ex vivo modalities has been used in the evaluation of skin cancer and other dermatological disorders. Recent developments in ex vivo confocal microscopy allow for faster pathology assessment with greater accuracy by the visualization of cellular and architectural details, similarly to standard pathology, in either paraffin-embedded or frozen samples. They include the possibility of multimodal confocal microscopy using different lasers and fusion images. New staining protocols including immunostaining, with no damage to conventional histopathology preparation, have been recently described in melanocytic tumours and inflammatory skin diseases. Digital staining with haematoxylin and eosin is also incorporated in the new devices. In this review the applications of ex vivo confocal microscopy will be presented with the description of the technique and the technology, clinical evidence in dermatology and other fields, and further applications.
Subject(s)
Dermatology , Skin Neoplasms , Humans , Microscopy, Confocal , Skin Neoplasms/diagnostic imagingABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Histiocytoma, Benign Fibrous/diagnosis , Drug Eruptions , Immunoconjugates/adverse effects , Histiocytoma, Benign Fibrous/physiopathology , Biopsy/methodsABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Mycetoma/diagnostic imaging , Ultrasonography/methods , Skin Diseases/diagnostic imaging , Mycetoma/pathology , Fusarium/isolation & purification , Aponeurosis , Subcutaneous Tissue/diagnostic imaging , Subcutaneous Tissue/pathologyABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Sentinel Lymph Node Biopsy/instrumentation , Melanoma/diagnostic imaging , Sentinel Lymph Node/surgery , Neoplasm Staging , Melanoma/surgery , Sentinel Lymph Node Biopsy , Minimally Invasive Surgical ProceduresSubject(s)
Melanoma/pathology , Sentinel Lymph Node Biopsy/methods , Skin Neoplasms/pathology , Female , Humans , Inguinal Canal , Middle AgedSubject(s)
Eyebrows , Mycetoma/diagnostic imaging , Aged , Female , Humans , Immunocompromised Host , Subcutaneous Tissue , UltrasonographyABSTRACT
No disponible
Subject(s)
Humans , Male , Aneurysm, False/etiology , Temporal Arteries , Postoperative Complications/surgeryABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Carcinoma, Basal Cell/diagnostic imaging , Head and Neck Neoplasms/diagnostic imaging , Scalp/pathology , Skin Neoplasms/diagnostic imaging , Dermoscopy , Microscopy, ConfocalSubject(s)
Carcinoma, Basal Cell/diagnosis , Head and Neck Neoplasms/diagnosis , Scalp/pathology , Skin Neoplasms/diagnosis , Adult , Carcinoma, Basal Cell/diagnostic imaging , Dermoscopy , Head and Neck Neoplasms/diagnostic imaging , Humans , Male , Microscopy, Confocal , Scalp/diagnostic imaging , Skin Neoplasms/diagnostic imagingABSTRACT
La infección por el virus del papiloma humano es una afección muy prevalente. Se revisan los aspectos más novedosos del tratamiento de las lesiones producidas por este virus, especialmente las verrugas anogenitales. Las sinecatequinas y las nuevas formulaciones de imiquimod destacan como novedades, mientras que la terapia fotodinámica y la inmunoterapia intralesional carecen de evidencia científica suficiente para recomendar su uso rutinario. Las vacunas terapéuticas y las moléculas inhibidoras parecen poseer un gran potencial, aun cuando se encuentran en fases iniciales de investigación. Sería deseable disponer de estudios más homogéneos, con muestras más grandes y con seguimientos suficientemente prolongados que permitiesen comparar directamente la efectividad entre las diferentes modalidades terapéuticas a corto y largo plazo (AU)
Human papillomavirus infection is very common. In this article, we review the latest developments in the treatment of lesions caused by this virus, with a particular focus on anogenital warts. Sinecatechins and new imiquimod formulations are among the most significant new developments. Others include photodynamic therapy and intralesional immunotherapy, but there is insufficient evidence to recommend their routine use. Finally, while therapeutic vaccines and inhibitory molecules appear to hold great promise, they are still in the early phases of investigation. More studies are needed, and these should have similar designs, larger samples, and sufficiently long follow-up periods to enable the direct comparison of the short-term and long-term effectiveness of different treatment options (AU)
Subject(s)
Humans , Papillomavirus Infections/drug therapy , Papillomavirus Vaccines/administration & dosage , Condylomata Acuminata/drug therapy , Antiviral Agents/therapeutic useABSTRACT
Human papillomavirus infection is very common. In this article, we review the latest developments in the treatment of lesions caused by this virus, with a particular focus on anogenital warts. Sinecatechins and new imiquimod formulations are among the most significant new developments. Others include photodynamic therapy and intralesional immunotherapy, but there is insufficient evidence to recommend their routine use. Finally, while therapeutic vaccines and inhibitory molecules appear to hold great promise, they are still in the early phases of investigation. More studies are needed, and these should have similar designs, larger samples, and sufficiently long follow-up periods to enable the direct comparison of the short-term and long-term effectiveness of different treatment options.