[Effect of Lurasidone on symptoms of schizophrenia in five-factor dimensional model: pooled analysis of two short-term, randomized, double-blind, placebo-controlled studies in patients from Russia and Ukraine]. / Ispol'zovanie piatifaktornoi dimensional'noi shkaly simptomov shizofrenii dlia otsenki terapevticheskogo deistviia Lurazidona: ob''edinennyi analiz dannykh dvukh kratkosrochnykh randomizirovannykh dvoinykh slepykh platsebo-kontroliruemykh issledovanii na populiatsii patsientov Rossii i Ukrainy.

AIM: Evaluation of a new five-factor dimensional model of schizophrenia in recent revisions of classifications of mental disorders (DSM-5 and ICD-11) dictates the need to use this approach in conducting a comprehensive assessment of the effectiveness of new antipsychotic agents, including ethnically homogeneous populations of patients. MATERIAL AND METHODS: Post-hoc analysis of pooled data from two randomized, double-blind, placebo-controlled, 6-week clinical studies (RCTs) of lurasidone (fixed doses, 40, 80, 120 or 160 mg/d) in patients experiencing an acute exacerbation of schizophrenia. Changes in PANSS total score, CGI-S score and five established PANSS factors were assessed using mixed-model repeated measures analysis. RESULTS: Lurasidone (n=162, dose groups pooled) compared with placebo (n=68), significantly improved the PANSS total score at Week 6 (-23.0 vs. -10.5; p<0.001; effect size 0.82) as well as all PANSS factor scores: positive symptoms (-8.5 vs. -4.2; p<0.001; effect size 0.88), negative symptoms (-4.4 vs. -2.8; p=0.011, effect size 0.44), disorganized thoughts (-4.4 vs. -2.1; p<0.001; effect size 0.70), hostility/excitement (-2.7 vs. -0.7; p<0.001; effect size 0.66), and depression/anxiety (-3.5 vs. -2.2; p=0.002; effect size 0.53). CONCLUSION: Lurasidone demonstrated significant improvement for both PANSS total score and each of the five PANSS factor scores, indicating effectiveness across the broad spectrum of schizophrenia symptoms. Effect size for both PANSS total score and each of the five PANSS factor scores for the local population was higher than for the wider population, which included patients from various countries.

Stationary waves in a superfluid exciton gas in quantum Hall bilayers.

Stationary waves in a superfluid magnetoexciton gas in ν = 1 quantum Hall bilayers are considered. The waves are induced by counterpropagating electrical currents that flow in a system with a point obstacle. It is shown that stationary waves can emerge only in imbalanced bilayers in a certain diapason of currents. It is found that the stationary wave pattern is modified qualitatively under a variation of the ratio of the interlayer distance to the magnetic length [Formula: see text]. The advantages of using graphene-dielectric-graphene sandwiches for the observation of stationary waves are discussed. We determine the range of parameters (the dielectric constant of the layer that separates two graphene layers and the ratio d/l) for which the state with superfluid magnetoexcitons can be realized in such sandwiches. Typical stationary wave patterns are presented as density plots.

Use of spinal manipulative therapy in the treatment of duodenal ulcer: a pilot study.

OBJECTIVE: To evaluate the effectiveness of spinal manipulative therapy (SMT) in the treatment of an internal organ disorder. DESIGN: Clinical trial. SETTING: Medical hospital. PATIENTS: Eleven adult men and women ranging in age from 18-44 yr with endoscopically confirmed diagnosis of ulcer disease took part in the study as an experimental group. The outcome of 24 cases of uncomplicated ulcerous disease treated by usual medical methods was analyzed as a control. INTERVENTIONS: The experimental group received spinal manipulative therapy (SMT) treatment from 5-22 days with a range of 3-14 procedures. The control group received traditional medical treatment (drug therapy and diet). The dietary regimen was standard for both groups. MEASUREMENTS: The effectiveness of the treatment was evaluated using clinical parameters and endoscopic examination performed weekly. MAIN RESULTS: The use of SMT resulted in pain relief after 1-9 (avg. 3.8) days and clinical remission an average of 10 days earlier than traditional care. CONCLUSIONS: Chiropractic practice often includes patients with gastrointestinal problems who report some relief of their symptoms after treatment; however, the physiological basis for these results has yet to be established. The normalization in segmental trophic innervation of the mucosal layer of the intestine, and positive reaction of the whole body, are under discussion as a possible mechanism for the treatment effect.

[The psychophysiological training of the crew members of multiseat aircraft for cooperation in accident situations]. / Psikhofiziologicheskaia podgotovka chlenov épiazhei mnogomestnykh letal'nykh apparatov k vzaimodeistviia v avariinykh situatsiiakh.

The article cites the results of the researching work that analyzes the crew cooperation in the conditions of an aircraft break-downs which were imitated at flight simulator; elaborates psychophysiological recommendations and makes its efficiency estimate. The authors state that psychophysiological recommendations could relieve routine work embarrassing situations, therefore promoting for better professional reliability of flight crews.