ABSTRACT
To develop new differential and diagnostic markers of different types of bronchopulmonary diseases, sodium-lithium countertransport through the red blood cell membrane was studied in 119 children, including 30 patients with bronchitis, 21 with pneumonia, and 68 apparently healthy children (a control group). The majority of patients with pneumonia were found to have the maximum high sodium-lithium countertransport rate as compared with patients with bronchitis, although high sodium-lithium countertransport rates are generally typical of children with bronchopulmonary diseases, as shown by absolute values. These indices may be attributable to the influence of a genetic determinant and environmental factors. For final verification of this suggestion, a follow-up of the study group of patients is scheduled, by taking into account a change in the phenotype of red blood cell populations.
Subject(s)
Antiporters/metabolism , Bronchitis/metabolism , Bronchitis/pathology , Pneumonia/metabolism , Pneumonia/pathology , Adolescent , Bronchitis/epidemiology , Cell Membrane/metabolism , Cell Membrane/pathology , Child , Female , Humans , Lung/metabolism , Lung/pathology , Male , Pneumonia/epidemiologyABSTRACT
The state of antibacterial humoral immunity in young children with acute bronchitis, acute obstructive bronchitis and bronchial asthma at the period of exacerbation has been shown with the use of the enzyme immunoassay. The concentration of antibodies to endotoxin positively correlates with the severity of clinical manifestations of the endogenic intoxication of the body. As the inflammatory process in the bronchial tree increases, the spectrum bacterial agents to which elevated concentrations of specific antibodies can be detected becomes wider, and this finds its maximum reflection in bronchial asthma.
Subject(s)
Antibodies, Bacterial/blood , Respiratory Tract Infections/immunology , Acute Disease , Antibody Formation , Asthma/immunology , Bronchitis/immunology , Child, Preschool , Chronic Disease , Humans , Immunoenzyme Techniques , InfantSubject(s)
Bacterial Adhesion/immunology , Bacterial Infections/etiology , Complement C3b/immunology , Neutrophils/immunology , Phagocyte Bactericidal Dysfunction/complications , Phagocytosis/immunology , Sepsis/etiology , Humans , Infant, Newborn , Phagocyte Bactericidal Dysfunction/immunology , PrognosisABSTRACT
As many as 63 infants with acute pneumonia, 7 children with ARVI (bronchiolitis) and 28 normal children were examined. At the height of the clinical manifestations there was an increase of the level of medium-weight molecules in blood serum, correlating well with the disease gravity determined by the intensity of the toxic syndrome. The highest concentration of serum medium-weight molecules was demonstrable in toxic and purulent complications due to acute pneumonia. Meanwhile the level of medium-weight molecules, equal to or exceeding 0.6 Units extinction may be viewed as an unfavourable predictor. No relationship was discovered between the concentration of serum medium-weight molecules and the type of virus causative agent and respiratory tract inflammation.
Subject(s)
Adenovirus Infections, Human/blood , Bacterial Infections/blood , Pneumonia, Viral/blood , Pneumonia/blood , Respirovirus Infections/blood , Toxins, Biological/blood , Acute Disease , Bacterial Toxins/blood , Biomarkers/blood , Child, Preschool , Humans , Infant , Molecular WeightABSTRACT
The authors suggest a method of functional probing of the complement alternative cascade, the jist of it being analysis of the neutrophil adhesion to sephadex granules treated with serum or another complement-containing substrate. The advantages of the method are analyzed, and the range of its application suggested.
