ABSTRACT
The effect of a native synthetic prostaglandin E1 on the blood supply and basic parameters of hemodynamics in acute myocardial ischemia induced by coronary artery occlusion was studied. It was found that the preparation in doses of 5 and 10 mg/kg increases the general and collateral coronary circulation by redistributing it into the endocardium of myocardial ischemic lesion. PGE1 increased the systolic discharge and the minute volume of the heart, enhanced the contractile myocardium activity. With an increase of the preparation dose its positive effect was not enhanced.
Subject(s)
Alprostadil/therapeutic use , Coronary Circulation/drug effects , Coronary Disease/drug therapy , Hemodynamics/drug effects , Prostaglandins E, Synthetic/therapeutic use , Acute Disease , Animals , Cats , Collateral Circulation/drug effects , Coronary Disease/diagnostic imaging , Coronary Disease/physiopathology , Dogs , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Female , Male , Phosphorus Radioisotopes , Radionuclide ImagingABSTRACT
In anesthetized cats, intravenous administration of nonachlazin (1 and 6 mg/kg) and ethmozine (2 and 5 mg/kg) led, 5 minutes after ligation of the anterior descending branch of the left coronary artery, to the increased blood outflow from the coronary sinus and to a less marked elevation of myocardial oxygen consumption. The coronarodilatory effect of the drugs fell in the presence of a preliminary injection of the sympatholytic octadin (25 mg/kg intraperitoneally), atropine (0.5 mg/kg intravenously), alpha-adrenoblocker dihydroergotoxin (2 mg/kg intravenously), and beta-adrenoblocker obsidan (0.5 mg/kg intravenously). Nonachlazin and ethmozine decreased the pituitrin-induced (2 ED/kg intravenously) spasm of the coronary vessels of the affected heart.
Subject(s)
Coronary Disease/drug therapy , Nonachlazine/therapeutic use , Phenothiazines/therapeutic use , Acute Disease , Animals , Cats , Coronary Circulation , Coronary Disease/metabolism , Coronary Disease/physiopathology , Female , Male , Moricizine , Morpholines/therapeutic use , Myocardium/metabolism , Oxygen ConsumptionABSTRACT
Systemic hemodynamics (thermodilution), retrograde coronary blood flow, oxygen tension and bioelectric activity of the myocardium were examined in dog experiments to show that nonachlazin produces an intensive and long-lasting increase in the collateral blood flow to the zone of acute myocardial ischemia and in the pressure in the ligated venous artery. Concurrently it elevates oxygen tension in the affected part of the heart. The cardiostimulant effect of the drug was associated with augmentation of the heart volume on account of an elevated stroke output in the presence of diminished general peripheral vascular resistance.
