[Genetic determinants of the efficiency of medium-wavelength ultraviolet irradiation of patients with psoriasis].

Therapeutic effect of medium-wavelength ultraviolet irradiation (UV therapy) in psoriatic patients is mediated through the p53-dependent mechanisms underlying apoptosis. The p53 gene is characterized by Arg/Pro polymorphism in codon 72 whose alleles exhibit differential functional activity. The present study has revealed association between p53 polymorphic variants and clinical efficiency of UV therapy in patients presenting with psoriasis. It enabled us to develop practical recommendations for predictive genetic testing of psoriatic patients; results of such testing make it possible to choose between the available treatment modalities on a patient-by-patient basis.