ABSTRACT
Steven Newmaster had been cleared, but fresh inquiry concludes he likely made up data.
ABSTRACT
The high-profile paper contains manipulated images, senior author acknowledges.
ABSTRACT
Inspectors faulted analyses of clinical trial samples by Hoau-Yan Wang for drug developer Cassava Sciences.
Subject(s)
Alzheimer Disease , Scientific Misconduct , Spiro Compounds , United States Food and Drug Administration , Humans , Alzheimer Disease/drug therapy , Spiro Compounds/therapeutic use , United States , Clinical Trials as TopicABSTRACT
Whistleblowers and former lab members suggest a star neuroscientist routinely manipulated data, compromising a planned NIH stroke trial and key Alzheimer's research.
Subject(s)
Alzheimer Disease , Scientific Misconduct , Stroke , Whistleblowing , Humans , Alzheimer Disease/therapy , Brain , Stroke/therapy , Clinical Trials as Topic , National Institutes of Health (U.S.)ABSTRACT
Co-developer of biotech's drug couldn't supply original data.
Subject(s)
Alzheimer Disease , Scientific Misconduct , Spiro Compounds , Humans , Alzheimer Disease/prevention & control , Biotechnology , United StatesABSTRACT
Amyloid-clearing antibody lecanemab faces key FDA hearing in June.
Subject(s)
Alzheimer Disease , Amyloid beta-Peptides , Antibodies, Monoclonal, Humanized , Brain , Humans , Alzheimer Disease/drug therapy , Alzheimer Disease/mortality , Amyloid beta-Peptides/immunology , Antibodies, Monoclonal, Humanized/adverse effects , Antibodies, Monoclonal, Humanized/therapeutic use , Autopsy , Brain/pathology , Clinical Trials as Topic , Fear , United States Food and Drug Administration , Female , AgedABSTRACT
Antibody slows cognitive decline, but deaths, brain bleeds, and swelling mar results.
Subject(s)
Alzheimer Disease , Antibodies, Monoclonal, Humanized , Apolipoprotein E4 , Humans , Alzheimer Disease/drug therapy , Alzheimer Disease/genetics , Apolipoprotein E4/genetics , Antibodies, Monoclonal, Humanized/therapeutic use , Randomized Controlled Trials as TopicABSTRACT
Matthew Schrag confronts a mentor after their joint work is flagged on the PubPeer website.
Subject(s)
Neurosciences , Scientific Misconduct , Whistleblowing , Humans , Mentors , Neurosciences/ethics , Alzheimer DiseaseABSTRACT
A neuroscience image sleuth finds signs of fabrication in scores of Alzheimer's articles, threatening a reigning theory of the disease.
Subject(s)
Alzheimer Disease , Amyloid beta-Peptides , Blotting, Western , Scientific Misconduct , Alzheimer Disease/drug therapy , Alzheimer Disease/metabolism , Amyloid beta-Peptides/chemistry , Amyloid beta-Peptides/metabolism , HumansABSTRACT
Report sees "insufficient evidence" of misconduct.
ABSTRACT
[Figure: see text].