ABSTRACT
Paraneoplastic syndromes (PNPs) refer to cancer-associated signs and symptoms arising in organs and tissues that are remote from the cancer and unrelated to metastasis. Currently the best described PNPs are attributed to tumor secretion of functional peptides and hormones or immune cross-reactivity between tumor and normal host tissues. Paraneoplastic hematologic syndromes are observed more rarely. Here we report a case of paraneoplastic granulocytosis in an advanced lung cancer patient.
Subject(s)
Carcinoma, Non-Small-Cell Lung/diagnosis , Granulocytes/pathology , Leukocytosis/diagnosis , Lung Neoplasms/diagnosis , Paraneoplastic Syndromes/diagnosis , Adrenal Gland Neoplasms/secondary , Brain Neoplasms/secondary , C-Reactive Protein/analysis , Carcinoma, Non-Small-Cell Lung/secondary , Fatal Outcome , Humans , L-Lactate Dehydrogenase/analysis , Lymphatic Metastasis/diagnosis , Male , Middle AgedSubject(s)
Agranulocytosis/diagnosis , Thrombocytopenia, Neonatal Alloimmune/diagnosis , Agranulocytosis/blood , Agranulocytosis/immunology , Diagnosis, Differential , Female , Humans , Infant, Newborn , Leukocyte Count , Neutrophils/cytology , Pregnancy , Thrombocytopenia, Neonatal Alloimmune/blood , Thrombocytopenia, Neonatal Alloimmune/immunologyABSTRACT
BACKGROUND: Plasmodium vivax is the second most common species among cases of imported malaria diagnosed in Europe. The objective of this study is to describe the sensitivity of the parasitological tests in imported P. vivax malaria, and the impact of chemoprophylaxis and attack type (primary infection or relapse). METHODS: A retrospective study included the imported vivax malaria cases admitted in a French military hospital between 2001 and 2013. The reference diagnosis method was microscopy corrected by polymerase chain reaction (PCR). Thin and thick blood films examination, quantitative buffy coat (QBC) test, and a rapid diagnostic test (RDT) had been systematically performed. PCR had been carried out for ambiguous profiles. RESULTS: Eighty-nine cases recorded from 78 patients were included, 65 of them having recently traveled to French Guyana. Forty-two patients had properly followed chemoprophylaxis. Forty-six cases were primary infections while 43 were relapses. The sensitivity was 91% for the thin blood smear, 96% for the concentration techniques (Giemsa thick blood smear and QBC test), and 76% for the RDT. The combination of the three conventional tools has an imperfect sensitivity, both for the positive diagnosis of malaria (96%) and for the diagnosis of vivax species (80%). In 4% of the cases, the positive diagnosis was established only by the PCR. The species identification was established in 20% by the PCR. The sensibility of thin blood smear and of RDT decreased significantly with full compliance of chemoprophylaxis or primary infection, whereas the decrease of sensibility of concentration techniques was not significant. CONCLUSIONS: This study illustrates the difficulties encountered in vivax malaria diagnosis, especially in patients who properly followed chemoprophylaxis or with primary infection due to a lower parasitemia. It underlines the lack of sensitivity of RDT for P. vivax and emphasizes the need for systematically combining various diagnosis methods.
Subject(s)
Antimalarials/therapeutic use , Chemoprevention/methods , Malaria, Vivax , Microscopy/methods , Parasitology/methods , Plasmodium vivax , Adult , Female , France/epidemiology , Guinea/epidemiology , Hospitals, Military , Humans , Malaria, Vivax/diagnosis , Malaria, Vivax/drug therapy , Malaria, Vivax/epidemiology , Malaria, Vivax/physiopathology , Male , Patient Acuity , Plasmodium vivax/genetics , Plasmodium vivax/isolation & purification , Polymerase Chain Reaction/methods , Recurrence , Retrospective Studies , Sensitivity and Specificity , TravelABSTRACT
We report a cluster of cutaneous leishmaniasis due to Leishmania major in four immunocompetent travelers returning from Western Turkmenistan and having atypical and/or multiple lesions. Treatments with pentamidine or fluconazole were effective. Physicians should be aware that some virulent strains of L major currently circulate in Central Asia.
