[Aseptic bone necrosis in lupus disease]. / Aseptichni kostni nekrozi pri lupusnata bolest.

Seven cases with aseptic necrosis in lupus disseminatus are presented being 9.70 per cent of 72 patients with confirmed systemic lupus, observed in the cours of 20 years. Six cases with lupus disseminatus are concerned--acute and subacute paroxysm a course and one case with chronic skin form--discoid lupus, complicated in the course of its evolution with aseptic necrosis of the right head of the femur. The cause for detection of the bone lesions in the cases presented, was the pain, especially manifested with the necrosis localized in the supporting bones of the lower limbs. The analysis of the state of the patients with systemic lupus reveals that all cases, are severe forms of the disease with multiorgan involvement, febrile reactions and the presence of vascular phenomena--Raynaud syndrome, coronary and cerebral arteriitis. High doses of corticosteroid preparations were used in the treatment of the disease due to its lasting progress (paroxysms of 8--12 months).

[Treatment of rheumatoid arthritis with a preparation of Sanokrizin--intravenous administration]. / Lechenie na revmatoidniia artrit s preparata Sanokrizin--venozno prilozhenie

Treatment with the preparation "Sanokrizin", applied i. v. has been carried out to 50 patients with rheumatoid polyarthritis--32 seropositive and 18 seronegative forms, being with a duration of the morbid process from one to 17 years. Therapeutic effect was obtained in 78 per cent of the cases, followed up from six months to one year while that therapy proved to be without effect in 22 per cent of the patients or only separate symptoms of the inflammatory process were partially affected. The preparation has a good tolerance and the side-effects, in the absence of controlled auremia, are overcome with discontinuation of the carried out treatment and only to two of the patients corticosteroids were given additionally. With an average dose, per course, of 1751,60 mg effect was also obtained upon single symptoms of the rheumatoid inflammation. The patients, effected at the earliest in the course of the therapeutic process, are with the best and most durable therapeutic effect and that might be used as a prognostic criterion for the favourable effect of the carried out treatment with the preparation "Sanokrizin".