1.
J Nat Prod
; 62(10): 1443-4, 1999 Oct.
Article
in English
| MEDLINE
| ID: mdl-10543914
ABSTRACT
11-Deoxyfistularin-3 (1), a new bromotyrosine derivative, was isolated among other known compounds such as fistularin-3 (2), aerothionin (3), and 11-oxoaerothionin (4) from the Caribbean sponge Aplysinafistularis (Aplysinellidae). The structure of 1 was determined by spectroscopic analysis and showed in vitro activity against the human breast carcinoma cell line MCF-7.
Subject(s)
Antineoplastic Agents/isolation & purification , Porifera/chemistry , Tyrosine/analogs & derivatives , Animals , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Humans , Molecular Structure , Spectrum Analysis , Tumor Cells, Cultured , Tyrosine/chemistry , Tyrosine/isolation & purification , Tyrosine/pharmacology
2.
J Nat Prod
; 58(8): 1209-16, 1995 Aug.
Article
in English
| MEDLINE
| ID: mdl-7595589
ABSTRACT
Five new cytotoxic cembranolides possessing a rare 4,7-oxa-bridged functionality were isolated from the gorgonian Eunicea mammosa. The structures of 5, 7-9, and 10 were deduced from spectroscopic data and by chemical correlation experiments.