ABSTRACT
The cytotoxic and genotoxic effects of a phosphate bone cement on human peripheral lymphocyte cultures exposed for 48 hr were determined. The mitotic index and the integrity of the DNA molecule were used as biocompatibility markers. It was found that the cement was not cytotoxic, but genotoxic at concentrations of >/=100 microg/ml. The cement was also characterized using scanning electron microscopy (SEM) and X-ray diffraction (XRD). (Journal of Applied Biomaterials and Biomechanics 2005; 3: 29-34).
ABSTRACT
The evolution of dog femur bone implanted in vivo with either steel or with a metal alloy (zinalco), was compared at different time-periods inverted exclamation markU9 months. Bone behavior was studied by radiology, scanning electron microscopy (SEM), thermo-gravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR) and it was shown that zinalco corroded whereas the steel remained unaltered in the presence of body fluids. Small amounts of metal ions were released continuously, promoting disordered bone growth enriched with organic tissue. After 9 months, the organism managed to compensate for this effect and the proportion of mineral to organic tissue resulted in being normal, although it was unable to correct the shape and the direction of the growth.
