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1.
Lasers Med Sci ; 28(2): 431-6, 2013 Feb.
Article in English | MEDLINE | ID: mdl-22399243

ABSTRACT

It has been demonstrated that reactive oxygen species (ROS) formation and oxidative damage markers are increased after muscle damage. Recent studies have demonstrated that low-level laser therapy (LLLT) modulates many biochemical processes mainly those related to reduction of muscular injures, increment of mitochondrial respiration and ATP synthesis, as well as acceleration of the healing process. The objective of the present investigation was to verify the influence of LLLT in some parameters of muscular injury, oxidative damage, antioxidant activity, and synthesis of collagen after traumatic muscular injury. Adult male Wistar rats were divided randomly into three groups (n = 6), namely, sham (uninjured muscle), muscle injury without treatment, and muscle injury with LLLT (GaAs, 904 nm). Each treated point received 5 J/cm(2) or 0.5 J of energy density (12.5 s) and 2.5 J per treatment (five regions). LLLT was administered 2, 12, 24, 48, 72, 96, and 120 h after muscle trauma. The serum creatine kinase activity was used as an index of skeletal muscle injury. Superoxide anion, thiobarbituric acid reactive substance (TBARS) measurement, and superoxide dismutase (SOD) activity were used as indicators of oxidative stress. In order to assess the synthesis of collagen, levels of hydroxyproline were measured. Our results have shown that the model of traumatic injury induces a significant increase in serum creatine kinase activity, hydroxyproline content, superoxide anion production, TBARS level, and activity of SOD compared to control. LLLT accelerated the muscular healing by significantly decreasing superoxide anion production, TBARS levels, the activity of SOD, and hydroxyproline content. The data strongly indicate that increased ROS production and augmented collagen synthesis are elicited by traumatic muscular injury, effects that were significantly decreased by LLLT.


Subject(s)
Low-Level Light Therapy/methods , Muscle, Skeletal/injuries , Muscle, Skeletal/metabolism , Muscle, Skeletal/radiation effects , Animals , Antioxidants/metabolism , Cell Respiration/radiation effects , Collagen/metabolism , Creatine Kinase/blood , Disease Models, Animal , Hydroxyproline/metabolism , Male , Mitochondria/metabolism , Mitochondria/radiation effects , Oxidative Stress/radiation effects , Rats , Rats, Wistar , Soft Tissue Injuries/metabolism , Soft Tissue Injuries/radiotherapy , Superoxide Dismutase/metabolism , Thiobarbituric Acid Reactive Substances/metabolism
2.
Rev. bras. cineantropom. desempenho hum ; 14(2): 174-182, 2012. ilus, tab
Article in Portuguese | LILACS | ID: lil-618221

ABSTRACT

Vários estudos têm investigado as alterações na resposta bioquímica em triatletas participantes de provas de Ironman, mas poucos dados relatam as mudanças de estresse oxidativo. O estudo teve como objetivo investigar os parâmetros de estresse oxidativo em triatletas após corrida de Ironman. Participaram do estudo, dezoito triatletas do sexo masculino, com idade média de 34,5 ± 2,15 anos, peso 69,3 ± 1,9 kg e altura 1,71 ± 0,18 m participaram do estudo. A corrida de Ironman consiste em 3,8 km de natação, 180 km de bicicleta e 42,2 km de corrida. Antes da corrida e imediatamente após seu término foi retirado 10 mL de sangue, sendo o mesmo centrifugado e armazenado o soro em freezer -80ºC para posteriores análises. A capacidade antioxidante total, lipoperoxidação, carbonilação de proteínas e conteúdo total de tióis foram determinadas. Os resultados mostraram um aumento significativo na quantidade de hidroperóxidos, carbonilação de proteínas e uma redução na capacidade antioxidante total do plasma e no conteúdo total de tióis após a prova (p<0.05) em relação à pré-prova, concluindo que a prova de Ironman provoca alterações significativas nos marcadores de estresse oxidativo em atletas e que uma suplementação com antioxidantes seria importante para reverter estes efeitos.


Several studies have investigated the biochemical response changes that take place in Ironman triathletes, but there are few data on oxidative stress changes. The objective of this study was to investigate oxidative stress parameters in triathletes after an Ironman event. The sample consisted of eighteen male triathletes, with a mean age of 34.5 ± 2.15 years, weight 69.3 ± 1.9 kg, and height 1.71 ± 0.18 m. The Ironman triathlon consists of a 3.8-km swim, a 180-km bicycle ride, and a 42.2-km (marathon) run. Before the competition and immediately after its conclusion, 10-mL blood samples were collected, centrifuged and frozen at -80ºC for subsequent analysis. Total antioxidant capacity, lipid peroxidation, protein carbonylation, and total thiol content were measured. The results showed a significant increase in all markers after the event (p<0.05) in relation to the pre-event period, which conclusively shows that the Ironman triathlon induces significant changes oxidative stress markers in athletes and that antioxidant supplementation would be important to reverse these effects.

3.
Article in Portuguese | LILACS | ID: lil-549658

ABSTRACT

O futsal é uma modalidade esportiva que requer súbita aceleração e desaceleração com brusca mudança de direção. Este esporte expõe seus praticantes a grandes impactos, causando danos musculares e oxidativos. O objetivo desta pesquisa foi avaliar os níveis séricos de marcadores de danos musculares e oxidativos em atletas após jogo defutsal. Participaram do estudo, seis atletas de futsal, com idade média (21,2 ± 0,98 anos), peso (67,1± 5,5 kg) e altura (171,0 ± 0,07 cm). As coletas foram obtidas 30 minutos antes do jogo 1 (Pré-jogo); imediatamente após o jogo 1 (pós-jogo 1) e imediatamente após osegundo jogo (pós-jogo 2), que foi realizado 24 horas após o jogo 1. O soro foi utilizado para avaliações séricas de creatina quinase, dano protéico e lipídico. As concentrações de creatina quinase, peroxidação lipídica (xilenol) e carbonilação de proteína (carbonil) foramsignificativamente maiores após o término dos jogos 1 e 2, quando comparadas aos valores pré jogo. Os valores de sulfidrila foram menores após o término dos jogos 1 e 2, quando comparados aos valores pré jogo. Nenhuma diferença foi observada quando comparados os valores após jogo 1 e o jogo 2 em todos os parâmetros analisados. Coletivamente, os resultados demonstram que a partida de futsal provoca danos musculares e oxidativos. Surpreendentemente, não houve incremento nos parâmetros avaliados ao final do jogo 2. Devido ao reduzido conhecimento em relação ao tempo de recuperação após uma partida de futsal, acredita-se que este estudo seja de grande importância para os profissionais que trabalham com esse esporte.


Futsal is a sport that requires sudden acceleration and deceleration with abrupt changes in direction. The marked impacts experienced by futsal players lead to muscle and oxidative damage. The objective of this study was to evaluate the serum levels of markers of muscle and oxidative damage in futsal players after a game. Six players with a mean age of 21.2 ± 0.98 years, weight of 67.1 ± 5.5 kg and height of 171.0 ± 0.07 cm participated in this study. Measurements were obtained 30 minutes before game 1 (pre-game), immediately after game 1 (post-game 1), and immediately after a second game (post-game 2), which was performed 24hours after game 1. Serum was collected for the evaluation of creatine kinase and of damage to proteins and lipids. Creatine kinase concentrations, lipid peroxidation (xylenol) and protein carbonylation were significantly higher after games 1 and 2 when compared to pre-game values. Sulfhydryl levels were lower after the end of games 1 and 2 compared to pre-game values. No difference in any of the parameters analyzed was observed between post-game 1 and post-game2. Taken together, the results demonstrate that a futsal match provokes muscle and oxidative damage. Surprisingly, no increase in the parameters studied was observed after game 2. In view of the limited knowledge about the time of recovery after a futsal match, this study may provideimportant information to professionals working with this sport.

4.
Article in Portuguese | LILACS | ID: lil-530810

ABSTRACT

Estudos têm apontado o exercício físico regular de baixa a moderada intensidade como um importante agente no combate ao estresse oxidativo pulmonar. Esse estudo investigou o efeito preventivo e terapêutico do exercício físico na resposta oxidativa pulmonar induzida por Bleomicina (BLM). Métodos: 36 camundongos machos (CF1, 30-35g) foram divididos em 6 grupos (n=6): não treinados salina ou BLM, treinamento preventivo salina ou BLM, treinamento terapêutico salina ou BLM e receberam endotraquealmente uma única dose de BLM (2,5U/Kg em 0,25mL de soro estéril) ou salina (0,9%). Os grupos treinados realizaram um programa de exercício progressivo em esteira durante 8 semanas (até 17m.min-1, 50min.dia-1). O grupo preventivo iniciou o programa de exercício 62 diasantes da administração de BLM e o grupo terapêutico 62 dias após a administração de BLM. Quarenta e oito horas após o período experimental, todos os animais foram mortos por decapitação e o pulmão direito foi cirurgicamente removido. Foi determinado o conteúdode hidroxiprolina, os níveis de TBARS e carbonilação de proteínas, atividades da superóxido dismutase e catalase. Os resultados mostram que os treinamentos preventivo e terapêutico reduzem significativamente o conteúdo de hidroxiprolina e inibem o aumento nos marcadores de danos oxidativos em lipídeos e proteínas. Contudo, somente o treinamentoterapêutico reduziu a atividade da SOD e catalase nos animais expostos a BLM. A realização de treinamento físico antes ou após da lesão pulmonar é um agente capaz de minimizar o estresse oxidativo induzido pela BLM.


Studies have shown that regular physical exercise of moderate intensity is an important tool for the control of pulmonary oxidative stress. The objective of this study was to examine the preventive and therapeutic effect of physical exercise on oxidative stress in the lungs of mice exposed to bleomycin (BLM). Thirty-six male mice (CF1, 30-35 g) received a single endotracheal dose of BLM (2.5 U/kg body weight dissolved in 0.25 mL 0.9% NaCl) or saline (0.9% NaCl) and were divided into six groups (n=6): untrained saline or BLM, preventive training saline or BLM, and therapeutic training saline or BLM. The trained groups underwent a program of progressive exercise on a treadmill for 8 weeks (up to 17 m.min-1, 50 min.day-1). The preventive group started the exercise program 62 days before the administration of BLM and the therapeutic group 62 days after the administration of BLM. All animals were killed by decapitation 48 hours after the experimental period, and the right lung was surgically removed for the determination of biochemical parameters. Hydroxyproline content, TBARS level, protein carbonylation, and superoxide dismutase (SOD) and catalase (CAT) activities were analyzed. The results showed that preventive and therapeutic training led to a significant reduction in hydroxyproline content and inhibited the increase in oxidative damage to lipids and proteins. However, only therapeutic training decreased SOD and CAT activities in mice exposed to BLM. The results suggest that preventive and therapeutic physical exercise is able to minimize pulmonary oxidative stress induced by BLM.

5.
Rev. bras. cineantropom. desempenho hum ; 11(2): 160-165, 29/04/2009. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: lil-515518

ABSTRACT

O objetivo do presente estudo foi investigar a resposta aguda de duas sessões de natação sobre parâmetros de estresse oxidativo em indivíduos fisicamente ativos.   Doze sujeitos homens (28±7anos, 1,75±0.08m, 72.9±9kg) com experiência em nata??ão superior a um ano de treinamento realizaram duas sessões de natação, 1 hora por sessão, com intervalo de 12 horas. Foram coletadas amostras de sangue da veia cubital 24 horas antes de prova (C1), imediatamente após a primeira sessão (C2) e segunda sessão (C3) e 24 horas após o término da prova (C4). Foram analisados as atividades da Creatina Quinase (CK), os níveis lipoperoxidação, carbonilação de proteínas e conteúdo total de tióis a atividade da catalase. Os resultados mostram um aumento na atividade da CK (1143.8 ± 254.2 U/L) nos níveis de lipoperoxidação (3.01± 0.54 nmol/TBARS/mg proteína) e carbonilação de proteínas (3.01±0.54 nmol/mg de proteína) e uma diminuição no conteúdo total de tióis (17.09±3.31 nmol TNB/mg proteína) imediatamente após a segunda sessão de natação em comparação a pré-prova (111.2±33.2 U/L; 1.68±0.34 nmol/TBARS/mg proteína; 1.68±0.34 nmol/mg de proteína; 26.8±3.08 nmol TNB/mg de proteína) respectivamente. A atividade da catalase aumentou após as duas sessões (C2; 2.5±0.35 U/mg proteína; C3; 2.5±0.47 U/mg proteína) em comparação a pré-prova (C1; 1.5±0.35 U/mg proteína). Em conclusão, somente a segunda sessão de natação alterou os parâmetros de estresse oxidativo.


This study investigated the acute effect of two swimming sessions on oxidative stress markers in trained individuals. Twelve male volunteers, students from UNESC (Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina, Brazil), with a mean age of 28 ± 7  years, initial weight of 72.9 ± 9 kg and height of 1.75 ± 0.08 cm, participated in the study. Blood samples were collected 24 hours before the sessions, immediately after the first and second session, and 24 hours after the end of the sessions. Aliquots were washed, red blood cells were lysed and plasma samples were stored at ?-80  oC until the time of the biochemical assays. Creatine kinase (CK) activity, lipid peroxidation level, protein carbonylation, thiol content and catalase activity were determined. The results showed a significant increase in CK, lipoperoxidation and protein carbonylation and a decrease in thiol content after the second swimming session (p<0.05) compared to pre-swimming levels. Catalase activity increased after the first and second swimming sessions. The main finding of the present study was that only the second swimming session resulted in oxidative stress.

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