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1.
J Periodontol ; 80(9): 1399-405, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19722789

ABSTRACT

BACKGROUND: The aim of this retrospective long-term split-mouth study was to compare the periodontal conditions of sites treated with gingival-augmentation procedures to untreated homologous contralateral sites over a long period of time (10 to 27 years). METHODS: Fifty-five subjects with 73 sites (test group) lacking attached gingiva associated with recessions were treated by means of submarginal free gingival grafts (SMFGGs) and marginal free gingival grafts (MFGGs). The 73 contralateral homologous sites (control group), with or without recession and with or without attached gingiva, were not treated. Patients were recalled every 4 months during the follow-up period (10 to 27 years). Clinical variables, including recession depth, amount of keratinized tissue (KT), and probing depth (PD), were measured in treated and untreated sites at baseline, at 1 year, and at the end of the follow-up period. RESULTS: At the end of the follow-up period, recession was reduced in all treated sites (1.5 +/- 1.0 mm for SMFGG and 1.3 +/- 0.9 mm for MFGG), whereas it was increased in the untreated sites (-0.7 +/- 0.7 mm for SMFGG and -1.0 +/- 0.5 mm for MFGG). In the treated sites, the increased KT remained quite stable during the follow-up period. PD remained stable (1 mm) in the treated and untreated sites. CONCLUSIONS: The sites treated with gingival-augmentation surgery showed a tendency for coronal displacement of the gingival margin with a reduction in recession. The contralateral untreated sites showed a tendency for apical displacement of the gingival margin with an increase in the existing recessions.


Subject(s)
Gingival Recession/surgery , Gingivoplasty/methods , Periodontal Index , Adolescent , Adult , Case-Control Studies , Cohort Studies , Dentin Sensitivity/pathology , Disease Progression , Female , Follow-Up Studies , Gingiva/pathology , Gingiva/transplantation , Gingival Pocket/pathology , Gingival Recession/pathology , Humans , Keratins , Longitudinal Studies , Male , Middle Aged , Periodontal Pocket/pathology , Retrospective Studies , Tooth Root/pathology , Young Adult
2.
J Periodontal Res ; 39(6): 442-6, 2004 Dec.
Article in English | MEDLINE | ID: mdl-15491349

ABSTRACT

OBJECTIVE: A possible relationship between periodontitis and cardiovascular disease has been suggested. The aims of this controlled clinical study were: (i) to ascertain the presence of periodontal bacteria DNA [Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis (formerly Bacteroides forsythus)] in carotid atheromatous plaques and (ii) to assess the concomitant presence of the same periodontal bacteria DNA, if any, in periodontal pockets and in carotid atheroma in the same patient. METHODS: A total of 52 patients scheduled for carotid endarderectomy were enrolled in this study. The test group consisted of 26 dentate patients; the control group included 26 edentulous patients. A complete periodontal examination, including radiographic orthopanoramic and subgingival plaque sample, was performed in the test population. Oral and X-ray examinations were performed in the control group. Atheromatous plaques were harvested during surgical procedure for each dentate and edentulous patient and then sent to the microbiological laboratory. Subgingival plaque samples and carotid specimens were examined using the polymerase chain reaction (PCR) technique by means of specific primers for periodontal bacteria. Amplification of extracted DNA was tested using human beta-globin specific-primers. RESULTS: Out of 52 endarterectomy samples, 12 (seven dentate, five edentulous patients) were excluded as negative to DNA amplification. In subgingival plaque samples of 19 test patients, T. forsythensis (79%), F. nucleatum (63%), P. intermedia (53%), P. gingivalis (37%) and A. actinomycetemcomitans (5%) were found. No periodontal bacteria DNA was detected by PCR in any of the carotid samples in either patient group. CONCLUSION: The presence of periodontal bacteria DNA in atheromatous plaques could not be confirmed by this study and thus no correlation could be established between species associated with periodontal disease and putative bacteria contributing to atheromatous plaques.


Subject(s)
Arteriosclerosis/microbiology , Carotid Artery Diseases/microbiology , Periodontal Pocket/microbiology , Aged , Aggregatibacter actinomycetemcomitans/isolation & purification , Arteriosclerosis/surgery , Bacteroides/isolation & purification , Carotid Artery Diseases/surgery , Case-Control Studies , DNA, Bacterial/analysis , Female , Fusobacterium nucleatum/isolation & purification , Humans , Male , Polymerase Chain Reaction , Porphyromonas gingivalis/isolation & purification , Prevotella intermedia/isolation & purification
3.
Minerva Stomatol ; 50(9-10): 321-30, 2001.
Article in Italian | MEDLINE | ID: mdl-11723432

ABSTRACT

Diabetes mellitus is an important disease of the endocrine system. Many studies have associated this disease to the pathogenesis and the severity of periodontal disease. The aim of this article is to illustrate the relation between diabetes mellitus and periodontal disease. Many studies show an important association between diabetes and the pathogenesis of periodontal disease. Vascular changes caused by hyperglycemia are associated to the development of periodontal pathogens species. Moreover diabetics show an exacerbate host response with hyperproduction of inflammatory mediators and polymorphonuclear dysfunction. Diabetics with good metabolic control and patients with good oral hygiene show a reduced risk of periodontitis. In conclusion, diabetes mellitus (IDDM and NIDDM) is an important risk factor for periodontitis. Odds Ratio is 3. Diabetes mellitus determines changes in bacterial population and production of inflammatory mediators, and reduces the efficacy of the host response. Good controlled diabetes do not cause a major risk of periodontitis and improve the results of the periodontal therapy. Moreover periodontal therapy may reduce the request of insulin in diabetics. It is reasonable a two-ways relation between diabetes and periodontal disease.


Subject(s)
Diabetes Complications , Periodontitis/etiology , Humans , Risk Factors
4.
Int J Periodontics Restorative Dent ; 20(6): 552-9, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11203591

ABSTRACT

Tissue engineering technology has been used in periodontal surgery. A patient who needed gingival augmentation prior to a single prosthetic restoration was treated by means of a tissue engineering technique. Results are presented in this case report.


Subject(s)
Fibroblasts/transplantation , Gingiva/transplantation , Gingival Recession/surgery , Gingivoplasty/methods , Adult , Biocompatible Materials , Cells, Cultured , Culture Media , Female , Follow-Up Studies , Gingiva/cytology , Gingivectomy , Humans , Hyaluronic Acid/analogs & derivatives , Membranes, Artificial , Surgical Flaps , Wound Healing
5.
J Clin Periodontol ; 25(9): 728-36, 1998 Sep.
Article in English | MEDLINE | ID: mdl-9763328

ABSTRACT

The aim of this randomized single-blind multicenter controlled clinical trial was to clinically evaluate the effectiveness of adjunctive local controlled drug delivery in the control of bleeding on probing in mandibular class II furcations during maintenance care. 127 patients presenting with a class II mandibular furcation with bleeding on probing were included in the study. They had been previously treated for periodontitis and were participating in supportive care programs in periodontal specialty practices. Treatments consisted of scaling and root planing with oral hygiene instructions (control) and scaling and root planing and oral hygiene combined with local controlled drug delivery with tetracycline fibers (test). The following outcomes were evaluated at baseline and 3 and 6 months after therapy at the furcation site: bleeding on controlled force probing (BOP), probing pocket depth (PD) and clinical attachment levels (CAL). Levels of oral hygiene and smoking status were also assessed. Both test and controls resulted in significant improvements of BOP and PD at 3 and 6 months. The test treatment, however, resulted in significantly better improvements: BOP decreased by 52% in the control group and by 70% in the test group at 3 months; at 6 months, however, the difference was no longer significant. The test treatment resulted in a 0.5 mm greater reduction of PD than the control at 3 months, the improvement was highly significant but its duration did not extend until the 6 months evaluation. No differences were observed in terms of changes in CAL. These data indicate that addition of tetracycline fibers to mechanical therapy alone resulted in improved control of periodontal parameters during periodontal maintenance of class II mandibular furcations. Short duration of the effect, however, requires further investigations to optimize conservative treatment of these challenging defects.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Furcation Defects/drug therapy , Gingival Hemorrhage/drug therapy , Tetracycline/therapeutic use , Adult , Anti-Bacterial Agents/administration & dosage , Combined Modality Therapy , Dental Scaling , Drug Implants , Female , Follow-Up Studies , Furcation Defects/therapy , Gingival Hemorrhage/therapy , Humans , Male , Mandible , Middle Aged , Oral Hygiene , Periodontal Attachment Loss/drug therapy , Periodontal Attachment Loss/therapy , Periodontal Pocket/drug therapy , Periodontal Pocket/therapy , Periodontitis/drug therapy , Periodontitis/therapy , Root Planing , Single-Blind Method , Smoking , Tetracycline/administration & dosage , Treatment Outcome
6.
J Clin Periodontol ; 22(9): 697-702, 1995 Sep.
Article in English | MEDLINE | ID: mdl-7593700

ABSTRACT

This controlled clinical trial evaluated the potential of fibrin glue as a biological carrier to locally deliver guided tissue regeneration (GTR) modulators, 2 controlateral, morphologically similar defects were selected in each of 11 patients and randomly assigned to the test (teflon membrane and fibrin glue) and the control treatment (teflon membrane alone). Outcomes were assessed at membrane removal as newly formed granulation tissue and at the 1-year follow-up in terms of changes in probing attachment level, probing pocket depth, recession of the gingival margin, probing bone levels and percentage of fill of the intrabony defects. Data confirmed that GTR treatment of deep intrabony defects results in clinically and statistically significant improvements of the clinical parameters. No significant differences, however, were evidenced between the test and the control treatments. It is suggested that, since fibrin glue did not show detrimental effects on GTR, it could be applied as a biological carrier for the delivery of GTR enhancers into the surgical wound.


Subject(s)
Fibrin Tissue Adhesive/therapeutic use , Furcation Defects/surgery , Guided Tissue Regeneration, Periodontal , Tissue Adhesives/therapeutic use , Adult , Alveolar Process/pathology , Female , Follow-Up Studies , Furcation Defects/pathology , Gingival Recession/pathology , Gingival Recession/surgery , Granulation Tissue/pathology , Humans , Male , Membranes, Artificial , Middle Aged , Periodontal Attachment Loss/pathology , Periodontal Attachment Loss/surgery , Periodontal Pocket/pathology , Periodontal Pocket/surgery , Polytetrafluoroethylene , Prospective Studies , Regeneration , Treatment Outcome
7.
Am J Orthod Dentofacial Orthop ; 105(1): 61-72, 1994 Jan.
Article in English | MEDLINE | ID: mdl-8291494

ABSTRACT

A surgical orthodontic procedure was used to treat deep infraosseous impacted canines (test teeth) associated with the persistence of the deciduous tooth in 15 patients who had the contralateral canine normally erupted (control teeth). The periodontal outcome was evaluated at the end of the orthodontic treatment and 3 years later. After extraction of the deciduous canine, a mucoperiosteal flap was raised on the buccal (seven cases) or palatal (eight cases) aspect, to expose the cusp of the impacted tooth. The empty socket of the deciduous tooth was extended to reach the impacted cusp and to form an osseous tunnel. A chain was passed through the tunnel and fixed to a bonded device on the impacted cusp. The flap was sutured back into its original position. The chain was used for traction to the impacted canine toward the center of the alveolar ridge. No attachment loss and no recession were observed at the end of the active therapy or 3 years later. No significant differences in keratinized tissue width were observed between test and control teeth at the follow-up examination.


Subject(s)
Alveolar Process/surgery , Cuspid/surgery , Tooth Movement Techniques/methods , Tooth, Impacted/therapy , Adolescent , Female , Follow-Up Studies , Humans , Male , Maxilla , Periodontal Index , Periodontal Pocket/complications , Surgical Flaps , Tooth Extraction , Tooth Movement Techniques/instrumentation , Tooth, Deciduous/surgery , Tooth, Impacted/complications , Tooth, Impacted/surgery , Traction/instrumentation , Traction/methods , Treatment Outcome
8.
Curr Opin Dent ; 1(1): 98-103, 1991 Feb.
Article in English | MEDLINE | ID: mdl-1912639

ABSTRACT

Soft-tissue plastic surgery was previously referred to as mucogingival surgery by Friedman (Tex Dent J 1957, 75:358-362). This term referred to any surgery "designated to preserve attached gingiva, to remove frena or muscle attachment, and to increase the depth of the vestibule." The aim of this type of surgery was to maintain an adequate mucogingival complex, focusing on the importance of the amount of attached gingiva. Soft tissue plastic surgery is important not only for reasons of health, but also for cosmetic purposes.


Subject(s)
Gingival Recession/surgery , Gingivoplasty , Vestibuloplasty , Gingiva/transplantation , Gingivectomy , Humans
11.
J Periodontol ; 59(10): 679-83, 1988 Oct.
Article in English | MEDLINE | ID: mdl-2460611

ABSTRACT

A case is reported showing an iatrogenic, chronic abscess of six years' duration associated with a bony defect between the maxillary right central and lateral incisors. The osseous defect was treated by a guided tissue regeneration procedure with the use of a fibrin and fibronectin sealing system. The system was employed to fix the membranes and keep them apart from the root surface, thereby maintaining room for bone regeneration. This operation resulted in a 9-mm clinical attachment gain and in an 11-mm filling of the osseous defect. The second surgical stage after a three-month reentry procedure was strictly for cosmetic improvement by means of a free gingival graft.


Subject(s)
Aprotinin/therapeutic use , Factor XIII/therapeutic use , Fibrin/therapeutic use , Fibrinogen/therapeutic use , Periodontal Abscess/surgery , Periodontitis/surgery , Periodontium/physiology , Regeneration , Thrombin/therapeutic use , Tissue Adhesives/therapeutic use , Adolescent , Alveolar Process/physiology , Bone Resorption/surgery , Drug Combinations/therapeutic use , Fibrin Tissue Adhesive , Humans , Male , Micropore Filters , Periodontium/surgery , Surgical Flaps , Tooth Root/surgery
16.
J Periodontol ; 58(6): 426-31, 1987 Jun.
Article in English | MEDLINE | ID: mdl-2439677

ABSTRACT

A fibrin-sealing system consisting of symmetrical flap and graft procedures versus silk sutures in a split-mouth clinical trial was tested in 51 patients. Clinical parameters and operative times were recorded and compared. In clinical use, the fibrin glue provided quick hemostasis and adequate tissue adhesion on the whole inner surface of grafts or flaps. Its use saved remarkable amounts of time and made it easier to fix tissues in difficult areas. The time saved ranged from 3 to 19.5 minutes per procedure, and 1 to 8.5 minutes per tooth. The convenience of the fibrin glue was especially appreciated in pedicle flap procedures.


Subject(s)
Aprotinin/therapeutic use , Factor XIII/therapeutic use , Fibrinogen/therapeutic use , Insect Proteins , Periodontal Diseases/surgery , Sutures , Thrombin/therapeutic use , Tissue Adhesives/therapeutic use , Adolescent , Adult , Child , Drug Combinations/therapeutic use , Female , Fibrin Tissue Adhesive , Humans , Male , Middle Aged , Proteins , Silk , Surgical Flaps , Time Factors , Wound Healing
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