Unveiling microbial guilds and symbiotic relationships in Antarctic sponge microbiomes.

Marine sponges host diverse microbial communities. Although we know many of its ecological patterns, a deeper understanding of the polar sponge holobiont is still needed. We combine high-throughput sequencing of ribosomal genes, including the largest taxonomic repertoire of Antarctic sponge species analyzed to date, functional metagenomics, and metagenome-assembled genomes (MAGs). Our findings show that sponges harbor more exclusive bacterial and archaeal communities than seawater, while microbial eukaryotes are mostly shared. Furthermore, bacteria in Antarctic sponge holobionts establish more cooperative interactions than in sponge holobionts from other environments. The bacterial classes that established more positive relations were Bacteroidia, Gamma- and Alphaproteobacteria. Antarctic sponge microbiomes contain microbial guilds that encompass ammonia-oxidizing archaea, ammonia-oxidizing bacteria, nitrite-oxidizing bacteria, and sulfur-oxidizing bacteria. The retrieved MAGs showed a high level of novelty and streamlining signals and belong to the most abundant members of the main microbial guilds in the Antarctic sponge holobiont. Moreover, the genomes of these symbiotic bacteria contain highly abundant functions related to their adaptation to the cold environment, vitamin production, and symbiotic lifestyle, helping the holobiont survive in this extreme environment.

What controls the remobilization and deformation of surficial sediment by seismic shaking? Linking lacustrine slope stratigraphy to great earthquakes in South-Central Chile.

Remobilization and deformation of surficial subaqueous slope sediments create turbidites and soft sediment deformation structures, which are common features in many depositional records. Palaeoseismic studies have used seismically-induced turbidites and soft sediment deformation structures preserved in sedimentary sequences to reconstruct recurrence patterns and - in some cases - allow quantifying rupture location and magnitude of past earthquakes. However, current understanding of earthquake-triggered remobilization and deformation lacks studies targeting where these processes take place, the subaqueous slope and involving direct comparison of sedimentary fingerprint with well-documented historical earthquakes. This study investigates the sedimentary imprint of six megathrust earthquakes with varying rupture characteristics in 17 slope sediment cores from two Chilean lakes, Riñihue and Calafquén, and evaluates how it links to seismic intensity, peak ground acceleration, bracketed duration and slope angle. Centimetre-scale stratigraphic gaps ranging from ca 1 to 20 cm - caused by remobilization of surficial slope sediment - were identified using high-resolution multi-proxy core correlation of slope to basin cores, and six types of soft sediment deformation structures ranging from ca 1 to 25 cm thickness using high-resolution three-dimensional X-ray computed tomography data. Stratigraphic gaps occur on slope angles of ≥2.3°, whereas deformation already occurs from slope angle 0.2°. The thickness of both stratigraphic gaps and soft sediment deformation structures increases with slope angle, suggesting that increased gravitational shear stress promotes both surficial remobilization and deformation. Seismic shaking is the dominant trigger for surficial remobilization and deformation at the studied lakes. Total remobilization depth correlates best with bracketed duration and is highest in both lakes for the strongest earthquakes (M w ca 9.5). In lake Riñihue, soft sediment deformation structure thickness and type correlate best with peak ground acceleration providing the first field-based evidence of progressive soft sediment deformation structure development with increasing peak ground acceleration for soft sediment deformation structures caused by Kelvin-Helmholtz instability. The authors propose that long duration and low frequency content of seismic shaking favours surficial remobilization, whereas ground motion amplitude controls Kelvin-Helmholtz instability-related soft sediment deformation structure development.

Bacteria Isolated From the Antarctic Sponge Iophon sp. Reveals Mechanisms of Symbiosis in Sporosarcina, Cellulophaga, and Nesterenkonia.

Antarctic sponges harbor a diverse range of microorganisms that perform unique metabolic functions for nutrient cycles. Understanding how microorganisms establish functional sponge-microbe interactions in the Antarctic marine ecosystem provides clues about the success of these ancient animals in this realm. Here, we use a culture-dependent approach and genome sequencing to investigate the molecular determinants that promote a dual lifestyle in three bacterial genera Sporosarcina, Cellulophaga, and Nesterenkonia. Phylogenomic analyses showed that four sponge-associated isolates represent putative novel bacterial species within the Sporosarcina and Nesterenkonia genera and that the fifth bacterial isolate corresponds to Cellulophaga algicola. We inferred that isolated sponge-associated bacteria inhabit similarly marine sponges and also seawater. Comparative genomics revealed that these sponge-associated bacteria are enriched in symbiotic lifestyle-related genes. Specific adaptations related to the cold Antarctic environment are features of the bacterial strains isolated here. Furthermore, we showed evidence that the vitamin B5 synthesis-related gene, panE from Nesterenkonia E16_7 and E16_10, was laterally transferred within Actinobacteria members. Together, these findings indicate that the genomes of sponge-associated strains differ from other related genomes based on mechanisms that may contribute to the life in association with sponges and the extreme conditions of the Antarctic environment.

24.0 kyr cal BP stone artefact from Vale da Pedra Furada, Piauí, Brazil: Techno-functional analysis.

Current archaeological paradigm proposes that the first peopling of the Americas does not exceed the Last Glacial Maximum period. In this context, the acceptance of the anthropogenic character of the earliest stone artefacts generally rests on the presence of projectile points considered no more as typocentric but as typognomonic, since it allows, by itself, to certify the human character of the other associated artefacts. In other words, without this presence, nothing is certain. Archaeological research at Piauí (Brazil) attests to a Pleistocene human presence between 41 and 14 cal kyr BP, without any record of lithic projectile points. Here, we report the discovery and interpretation of an unusual stone artefact in the Vale da Pedra Furada site, in a context dating back to 24 cal kyr BP. The knapping stigmata and macroscopic use-wear traces reveal a conception centred on the configuration of double bevels and the production in the same specimen of at least two successive artefacts with probably different functions. This piece unambiguously presents an anthropic character and reveals a technical novelty during the Pleistocene occupation of South America.

Annual phytoplankton dynamics in coastal waters from Fildes Bay, Western Antarctic Peninsula.

Year-round reports of phytoplankton dynamics in the West Antarctic Peninsula are rare and mainly limited to microscopy and/or pigment-based studies. We analyzed the phytoplankton community from coastal waters of Fildes Bay in the West Antarctic Peninsula between January 2014 and 2015 using metabarcoding of the nuclear and plastidial 18/16S rRNA gene from both size-fractionated and flow cytometry sorted samples. Overall 14 classes of photosynthetic eukaryotes were present in our samples with the following dominating: Bacillariophyta (diatoms), Pelagophyceae and Dictyochophyceae for division Ochrophyta, Mamiellophyceae and Pyramimonadophyceae for division Chlorophyta, Haptophyta and Cryptophyta. Each metabarcoding approach yielded a different image of the phytoplankton community with for example Prymnesiophyceae more prevalent in plastidial metabarcodes and Mamiellophyceae in nuclear ones. Diatoms were dominant in the larger size fractions and during summer, while Prymnesiophyceae and Cryptophyceae were dominant in colder seasons. Pelagophyceae were particularly abundant towards the end of autumn (May). In addition of Micromonas polaris and Micromonas sp. clade B3, both previously reported in Arctic waters, we detected a new Micromonas 18S rRNA sequence signature, close to, but clearly distinct from M. polaris, which potentially represents a new clade specific of the Antarctic. These results highlight the need for complementary strategies as well as the importance of year-round monitoring for a comprehensive description of phytoplankton communities in Antarctic coastal waters.

Characterizing the microbiomes of Antarctic sponges: a functional metagenomic approach.

Relatively little is known about the role of sponge microbiomes in the Antarctic marine environment, where sponges may dominate the benthic landscape. Specifically, we understand little about how taxonomic and functional diversity contributes to the symbiotic lifestyle and aids in nutrient cycling. Here we use functional metagenomics to investigate the community composition and metabolic potential of microbiomes from two abundant Antarctic sponges, Leucetta antarctica and Myxilla sp. Genomic and taxonomic analyses show that both sponges harbor a distinct microbial community with high fungal abundance, which differs from the surrounding seawater. Functional analyses reveal both sponge-associated microbial communities are enriched in functions related to the symbiotic lifestyle (e.g., CRISPR system, Eukaryotic-like proteins, and transposases), and in functions important for nutrient cycling. Both sponge microbiomes possessed genes necessary to perform processes important to nitrogen cycling (i.e., ammonia oxidation, nitrite oxidation, and denitrification), and carbon fixation. The latter indicates that Antarctic sponge microorganisms prefer light-independent pathways for CO2 fixation mediated by chemoautotrophic microorganisms. Together, these results show how the unique metabolic potential of two Antarctic sponge microbiomes help these sponge holobionts survive in these inhospitable environments, and contribute to major nutrient cycles of these ecosystems.

A late Pleistocene human footprint from the Pilauco archaeological site, northern Patagonia, Chile.

The present study describes the discovery of a singular sedimentary structure corresponding to an ichnite that was excavated at the paleo-archaeological site Pilauco (Osorno, Chile). The trace fossil is associated with megafauna bones, plant material and unifacial lithic tools. Here we present a detailed analysis of the Pilauco ichnite and associated sedimentary structures, as well as new radiocarbon data. The ichnological analysis confidently assigns the trace to the ichnospecies Hominipes modernus-a hominoid footprint usually related to Homo sapiens. Some particular characteristics of the Pilauco trace include an elongated distal hallux, lateral digit impressions obliterated by the collapsed sediment, and sediment lumps inside and around the trace. In order to evaluate the origin of the ichnite, trackmaking experiments are performed on re-hydrated fossil bed sediments. The results demonstrate that a human agent could easily generate a footprint morphology equivalent to the sedimentary structure when walking on a saturated substrate. Based on the evidence, we conclude that the trackmaker might well have been a bare-footed adult human. This finding, along with the presence of lithic artifacts in the same sedimentary levels, might represent further evidence for a pre-Clovis South American colonization of northern Patagonia, as originally proposed for the nearby Monte Verde site.

Sedimentary record from Patagonia, southern Chile supports cosmic-impact triggering of biomass burning, climate change, and megafaunal extinctions at 12.8 ka.

The Younger Dryas (YD) impact hypothesis posits that fragments of a large, disintegrating asteroid/comet struck North America, South America, Europe, and western Asia ~12,800 years ago. Multiple airbursts/impacts produced the YD boundary layer (YDB), depositing peak concentrations of platinum, high-temperature spherules, meltglass, and nanodiamonds, forming an isochronous datum at >50 sites across ~50 million km² of Earth's surface. This proposed event triggered extensive biomass burning, brief impact winter, YD climate change, and contributed to extinctions of late Pleistocene megafauna. In the most extensive investigation south of the equator, we report on a ~12,800-year-old sequence at Pilauco, Chile (~40°S), that exhibits peak YD boundary concentrations of platinum, gold, high-temperature iron- and chromium-rich spherules, and native iron particles rarely found in nature. A major peak in charcoal abundance marks an intense biomass-burning episode, synchronous with dramatic changes in vegetation, including a high-disturbance regime, seasonality in precipitation, and warmer conditions. This is anti-phased with northern-hemispheric cooling at the YD onset, whose rapidity suggests atmospheric linkage. The sudden disappearance of megafaunal remains and dung fungi in the YDB layer at Pilauco correlates with megafaunal extinctions across the Americas. The Pilauco record appears consistent with YDB impact evidence found at sites on four continents.

Multiproxy evidence for leaf-browsing and closed habitats in extinct proboscideans (Mammalia, Proboscidea) from Central Chile.

Proboscideans are so-called ecosystem engineers and are considered key players in hypotheses about Late Pleistocene megafaunal extinctions. However, knowledge about the autoecology and chronology of the proboscideans in South America is still open to debate and raises controversial views. Here, we used a range of multiproxy approaches and new radiocarbon datings to study the autoecology of Chilean gomphotheres, the only group of proboscideans to reach South America during the Great American Biotic Interchange (∼3.1 to 2.7 million years before present). As part of this study, we analyzed stable isotopes, dental microwear, and dental calculus microfossils on gomphothere molars from 30 Late Pleistocene sites (31° to 42°S). These proxies provided different scales of temporal resolution, which were then combined to assess the dietary and habitat patterns of these proboscideans. The multiproxy study suggests that most foraging took place in relatively closed environments. In Central Chile, there is a positive correlation between lower δ13C values and an increasing consumption of arboreal/scrub elements. Analyses of dental microwear and calculus microfossils have verified these leaf-browsing feeding habits. From a comparative perspective, the dietary pattern of South American gomphotheres appears to be constrained more by resource availability than by the potential dietary range of the individual taxa. This multiproxy study is aimed at increasing knowledge of the life history of gomphotheres and thus follows an issue considered one of the greatest challenges for paleontology in South America, recently pointed out by the need to thoroughly understand the role of ecological engineers before making predictions about the consequences of ecosystem defaunation.

Next Generation Sequencing and mass spectrometry reveal high taxonomic diversity and complex phytoplankton-phycotoxins patterns in Southeastern Pacific fjords.

In fjord systems, Harmful Algal Blooms (HABs) not only constitute a serious problem when affecting the wildlife and ecosystems, but also human health and economic activities related to the marine environment. This is mostly due to a broad spectrum of toxic compounds produced by several members of the phytoplankton. Nevertheless, a deep coverage of the taxonomic diversity and composition of phytoplankton species and phycotoxin profiles in HAB prone areas are still lacking and little is known about the relationship between these fundamental elements for fjord ecosystems. In this study, a detailed molecular and microscopic characterization of plankton communities was performed, together with an analysis of the occurrence and spatial patterns of lipophilic toxins in a HAB prone area, located in the Southeastern Pacific fjord region. Microscopy and molecular analyses based on the 18S rRNA gene fragment indicated high diversity and taxonomic homogeneity among stations. Four toxigenic genera were identified: Pseudo-nitzschia, Dinophysis, Prorocentrum, and Alexandrium. In agreement with the detected species, liquid chromatography coupled with mass spectrometry revealed the presence of domoic acid (DA), pectenotoxin-2 (PTX-2), dinophysistoxin-2 (DTX-2), and 13-desmethyl spirolide C (SPX-1). Furthermore, a patchy distribution among DA in different net haul size fractions was found. Our results displayed a complex phytoplankton-phycotoxin pattern and for the first time contribute to the characterization of high-resolution phytoplankton community composition and phycotoxin distribution in fjords of the Southeastern Pacific region.

Simple technologies and diverse food strategies of the Late Pleistocene and Early Holocene at Huaca Prieta, Coastal Peru.

Simple pebble tools, ephemeral cultural features, and the remains of maritime and terrestrial foods are present in undisturbed Late Pleistocene and Early Holocene deposits underneath a large human-made mound at Huaca Prieta and nearby sites on the Pacific coast of northern Peru. Radiocarbon ages indicate an intermittent human presence dated between ~15,000 and 8000 calendar years ago before the mound was built. The absence of fishhooks, harpoons, and bifacial stone tools suggests that technologies of gathering, trapping, clubbing, and exchange were used primarily to procure food resources along the shoreline and in estuarine wetlands and distant mountains. The stone artifacts are minimally worked unifacial stone tools characteristic of several areas of South America. Remains of avocado, bean, and possibly cultivated squash and chile pepper are also present, suggesting human transport and consumption. Our new findings emphasize an early coastal lifeway of diverse food procurement strategies that suggest detailed observation of resource availability in multiple environments and a knowledgeable economic organization, although technologies were simple and campsites were seemingly ephemeral and discontinuous. These findings raise questions about the pace of early human movement along some areas of the Pacific coast and the level of knowledge and technology required to exploit maritime and inland resources.

Variation in coastal Antarctic microbial community composition at sub-mesoscale: spatial distance or environmental filtering?

Spatial environmental heterogeneity influences diversity of organisms at different scales. Environmental filtering suggests that local environmental conditions provide habitat-specific scenarios for niche requirements, ultimately determining the composition of local communities. In this work, we analyze the spatial variation of microbial communities across environmental gradients of sea surface temperature, salinity and photosynthetically active radiation and spatial distance in Fildes Bay, King George Island, Antarctica. We hypothesize that environmental filters are the main control of the spatial variation of these communities. Thus, strong relationships between community composition and environmental variation and weak relationships between community composition and spatial distance are expected. Combining physical characterization of the water column, cell counts by flow cytometry, small ribosomal subunit genes fingerprinting and next generation sequencing, we contrast the abundance and composition of photosynthetic eukaryotes and heterotrophic bacterial local communities at a submesoscale. Our results indicate that the strength of the environmental controls differed markedly between eukaryotes and bacterial communities. Whereas eukaryotic photosynthetic assemblages responded weakly to environmental variability, bacteria respond promptly to fine-scale environmental changes in this polar marine system.

New Archaeological Evidence for an Early Human Presence at Monte Verde, Chile.

Questions surrounding the chronology, place, and character of the initial human colonization of the Americas are a long-standing focus of debate. Interdisciplinary debate continues over the timing of entry, the rapidity and direction of dispersion, the variety of human responses to diverse habitats, the criteria for evaluating the validity of early sites, and the differences and similarities between colonization in North and South America. Despite recent advances in our understanding of these issues, archaeology still faces challenges in defining interdisciplinary research problems, assessing the reliability of the data, and applying new interpretative models. As the debates and challenges continue, new studies take place and previous research reexamined. Here we discuss recent exploratory excavation at and interdisciplinary data from the Monte Verde area in Chile to further our understanding of the first peopling of the Americas. New evidence of stone artifacts, faunal remains, and burned areas suggests discrete horizons of ephemeral human activity in a sandur plain setting radiocarbon and luminescence dated between at least ~18,500 and 14,500 cal BP. Based on multiple lines of evidence, including sedimentary proxies and artifact analysis, we present the probable anthropogenic origins and wider implications of this evidence. In a non-glacial cold climate environment of the south-central Andes, which is challenging for human occupation and for the preservation of hunter-gatherer sites, these horizons provide insight into an earlier context of late Pleistocene human behavior in northern Patagonia.

Draft Genome of Chilean Honeybee (Apis mellifera) Gut Strain Lactobacillus kunkeei MP2.

Here, we report the first draft genome sequence of Lactobacillus kunkeei strain MP2, isolated from a Chilean honeybee gut. The sequenced genome has a total size of 1.58 Mb distributed into 44 contigs and 1,356 protein-coding sequences.

Visión histórica del Hospital Provincial Docente de Oncología "María Curie" de Camagüey / Historical vision of the Provincial Teaching Oncology Hospital “María Curie” of Camagüey

Se realizó esta investigación con el objetivo de describir la evolución histórica del Hospital Provincial Docente de Oncología "María Curie" de Camagüey. Surgió con la constitución de la Liga Contra el Cáncer en Camagüey en 1941 hasta su desaparición en 1960, que logró el propósito inicial de construir un dispensario anticanceroso. Debido a la mala atención médica brindada por los gobiernos republicanos se destacó el gesto desinteresado del pueblo camagüeyano con su aporte económico para la construcción de este dispensario. Con el triunfo revolucionario se logró transformar en hospital, que junto al desarrollo de la Oncología en la provincia, es actualmente un centro de alto nivel científico para la atención al pueblo. La información fue obtenida de personalidades que participaron en su creación, fotos y periódicos de la época, además de documentos existentes en el Archivo Histórico de Camagüey.

An investigation was carried out with the objective of describing the historical evolution of the Provincial Teaching Oncology Hospital “María Curie” of Camagüey. It was originated with the constitution of the League against Cancer in Camagüey in 1941 until its disappearance in 1960, achieving the initial purpose of building up an anti-cancerous dispensary. Due to the bad medical attention given by the republican governments, it stood out the generous gesture of the people of Camagüey with its economic contribution for the construction of this dispensary. With the triumph of the revolution it was turned into a hospital, which together with the development of the oncology in the province is currently a high scientific level center for the attention of the people. The information was obtained from personalities that took part in its creation, photos and papers of the period, along with documents of the Historical Archive of Camagüey.

Visión histórica del Hospital Provincial Docente de Oncología María Curie de Camagüey / Historical vision of the Provincial Teaching Oncology Hospital

Se realizó esta investigación con el objetivo de describir la evolución histórica del Hospital Provincial Docente de Oncología María Curie de Camagüey. Surgió con la constitución de la Liga Contra el Cáncer en Camagüey en 1941 hasta su desaparición en 1960, que logró el propósito inicial de construir un dispensario anticanceroso. Debido a la mala atención médica brindada por los gobiernos republicanos se destacó el gesto desinteresado del pueblo camagüeyano con su aporte económico para la construcción de este dispensario. Con el triunfo revolucionario se logró transformar en hospital, que junto al desarrollo de la Oncología en la provincia, es actualmente un centro de alto nivel científico para la atención al pueblo. La información fue obtenida de personalidades que participaron en su creación, fotos y periódicos de la época, además de documentos existentes en el Archivo Histórico de Camagüey(AU)

An investigation was carried out with the objective of describing the historical evolution of the Provincial Teaching Oncology Hospital María Curie of Camagüey. It was originated with the constitution of the League against Cancer in Camagüey in 1941 until its disappearance in 1960, achieving the initial purpose of building up an anti-cancerous dispensary. Due to the bad medical attention given by the republican governments, it stood out the generous gesture of the people of Camagüey with its economic contribution for the construction of this dispensary. With the triumph of the revolution it was turned into a hospital, which together with the development of the oncology in the province is currently a high scientific level center for the attention of the people. The information was obtained from personalities that took part in its creation, photos and papers of the period, along with documents of the Historical Archive of Camagüey(AU)

Comportamiento del Cáncer Cérvico Uterino durante el quinquenio 2002-2006 en la Provincia Camagüey / Cervical cancer behavior during 2002- 2006 in Camagüey Province

Se realizó un estudio descriptivo y transversal para conocer el comportamiento del cáncer cérvico uterino en la provincia Camagüey durante el quinquenio 2002-2006, la muestra estuvo representada por 568 mujeres con este diagnóstico durante la etapa estudiada. Como fuente primaria de datos se utilizaron las historias clínicas individuales, el modelo 68-04 del MINSAP y una encuesta confeccionada a criterio de autores. Las variables seleccionadas fueron procesadas de forma computarizada. Los resultados se ilustraron en tablas permitiéndonos formular conclusiones y dar respuesta a nuestro objetivo. Durante el período estudiado se diagnosticaron en la provincia 568 casos de carcinoma del cuello uterino, falleciendo por ésta causa 245 pacientes. El grupo de edad de 40-44 años, resultó el de mayor número de casos. Se apreció relación significativa de esta neoplasia con los factores de riesgo descritos en la literatura; prevaleciendo el bajo nivel cultural, el inicio de las relaciones sexuales antes de los 18 años y el antecedente de infecciones de transmisión sexual. La etapa clínica II b fue la más común al diagnóstico y como variedad histológica con mayor frecuencia: el carcinoma epidermoide invasor, hallado en 79 por ciento de los diagnósticos.

A descriptive and cross-sectional study was carried out to know the behavior of uterine cervical cancer in Camagüey province from 2002 to 2006, the sample was represented by 568 women with this diagnosis during the studied time. As primary source of data individual clinical histories were used, the model a 68-04 of the MINSAP and a survey designed according to the authors’ criterion. The selected variables were processed in a computerized form. The results were illustrated in chart allowing formulating conclusions and giving answers to our objective. 568 people with cervical cancer were diagnosed during the studied period. For this reason 245 patients died. Most of the cases were between 40 and 44 years of age. A significant relation of this neoplasia with the risk factors described in literature was observed, being prevalent the low cultural background, the beginning of sexual intercourse before 18 years of age and sexual- transmitted -disease antecedent. Stage IIb was the commonest during the application of the diagnosis and as the most frequent historological variety: invasive epidermoid carcinoma, found in 79 percent of the diagnoses done

Comportamiento del Cáncer Cérvico Uterino durante el quinquenio 2002-2006 en la Provincia Camagüey / Cervical cancer behavior during 2002- 2006 in Camagüey Province

Se realizó un estudio descriptivo y transversal para conocer el comportamiento del cáncer cérvico uterino en la provincia Camagüey durante el quinquenio 2002-2006, la muestra estuvo representada por 568 mujeres con este diagnóstico durante la etapa estudiada. Como fuente primaria de datos se utilizaron las historias clínicas individuales, el modelo 68-04 del MINSAP y una encuesta confeccionada a criterio de autores. Las variables seleccionadas fueron procesadas de forma computarizada. Los resultados se ilustraron en tablas permitiéndonos formular conclusiones y dar respuesta a nuestro objetivo. Durante el período estudiado se diagnosticaron en la provincia 568 casos de carcinoma del cuello uterino, falleciendo por ésta causa 245 pacientes. El grupo de edad de 40-44 años, resultó el de mayor número de casos. Se apreció relación significativa de esta neoplasia con los factores de riesgo descritos en la literatura; prevaleciendo el bajo nivel cultural, el inicio de las relaciones sexuales antes de los 18 años y el antecedente de infecciones de transmisión sexual. La etapa clínica II b fue la más común al diagnóstico y como variedad histológica con mayor frecuencia: el carcinoma epidermoide invasor, hallado en 79 por ciento de los diagnósticos

A descriptive and cross-sectional study was carried out to know the behavior of uterine cervical cancer in Camagüey province from 2002 to 2006, the sample was represented by 568 women with this diagnosis during the studied time. As primary source of data individual clinical histories were used, the model a 68-04 of the MINSAP and a survey designed according to the authors criterion. The selected variables were processed in a computerized form. The results were illustrated in chart allowing formulating conclusions and giving answers to our objective. 568 people with cervical cancer were diagnosed during the studied period. For this reason 245 patients died. Most of the cases were between 40 and 44 years of age. A significant relation of this neoplasia with the risk factors described in literature was observed, being prevalent the low cultural background, the beginning of sexual intercourse before 18 years of age and sexual- transmitted -disease antecedent. Stage IIb was the commonest during the application of the diagnosis and as the most frequent historological variety: invasive epidermoid carcinoma, found in 79 percent of the diagnoses done