Comparative analysis of hydro energy determinants for European Economies using Golden Cut-oriented Quantum Spherical fuzzy modelling and causality analysis.

This article presents a comparative analysis of the determinants of hydropower for European economies using Golden Cut oriented Quantum Spherical fuzzy modelling and causality analysis in 24 European countries over the period 2001-2020. The indicators chosen for the analysis are inflation, population, GDP per capita, CO2 and hydropower consumption. The analysis shows that the selected groups of countries are characterised by an inverse relationship between GDP per capita and hydropower consumption, suggesting a bi-directional causal relationship, which also confirms the novelty of this paper. Furthermore, another analysis is carried out using the fuzzy decision-making methodology. In this framework, the directions of influence of the five selected indicators are constructed: GDP per capita (criterion 1, D = 88.656, E = 88.083), hydropower consumption (criterion 2, D = 89.471, E = 88.677), population (criterion 3, D = 87.705, E = 89.228), CO2 emissions (criterion 4, D = 88.578, E = 89.186) and inflation (criterion 5, D = 88.943, E = 88.180). The Quantum Spherical fuzzy methodology is used for this purpose. The values of D and E are measures of the sum of the rows and columns of the overall relationship matrix. Hydropower consumption is the main criterion. It is understood that two different analyses give similar results, namely the bidirectional causal relationship between criteria 1 and 2.

Dynamic Navigation for Dental Implant Placement.

In modern implantology, the application of surgical navigation systems is becoming increasingly important. In addition to static surgical navigation methods, a guide-independent dynamic navigation implant placement procedure is becoming more widespread. The procedure is based on computer-guided dental implant placement utilizing optical control. This work aims to demonstrate the technical steps of a new dynamic computer-aided implant surgery (DCAIS) system (design, calibration, surgery) and check the accuracy of the results. Based on cone-beam computed tomography (CBCT) scans, the exact positions of implants are determined with dedicated software. The first step of the operation is the calibration of the navigation system, which can be performed in two ways: 1) based on CBCT images taken with a marker or 2) based on CBCT images without markers. Implants are inserted with the aid of real-time navigation according to the preoperative plans. The accuracy of the interventions can be evaluated based on postoperative CBCT images. The preoperative images containing the planned positions of the implants and postoperative CBCT images were compared based on the angulation (degree), platform, and apical deviation (mm) of the implants. To evaluate the data, we calculated the standard deviation (SD), mean, and standard error of the mean (SEM) of deviations within planned and performed implant positions. Differences between the two calibration methods were compared based on this data. Based on the interventions performed so far, the use of DCAIS allows for high-precision implant placement. A calibration system that does not require labeled CBCT recording allows for surgical intervention with similar accuracy as a system that uses labeling. The accuracy of the intervention can be improved by training.

A Control Process for Active Solar-Tracking Systems for Photovoltaic Technology and the Circuit Layout Necessary for the Implementation of the Method.

What basically determines how much energy is generated by a photovoltaic (PV) system is the amount of solar irradiation that is absorbed by its PV modules. One of the technical solutions to boost this quantity, and thusly also maximize the return on PV investments, is solar tracking, which makes the following of the sun on its daily and annual journey in the sky possible and also takes changes in cloud conditions into consideration. The solar-tracking solutions that PV systems are most frequently equipped with deploy active sensor technologies, while passive ones are less common in present-day practice. However, even the popular solutions of today have their limitations. Their active sensor-tracking algorithms leave room for improvement for at least three major reasons, as they do not prevent the unnecessary operation of the motors in cloudy weather, they do not make the modules assume an appropriate position after nightfall, and they do not make sure that the structure and the electronics of the PV systems are protected from rain and the strong winds in the event of storms. This paper introduces a new active sensor-tracking algorithm, which has not only been tested but it is also in the process of patenting (patent ID: p2100209). By their contribution, the authors endeavor to propose a solution that can solve all three of the issues mentioned above. The concept is based on two fundamental findings. According to the first one, periodic movement can not only considerably decrease motor movement but also increase system lifetime, while the second one simply suggests that moving the modules into an almost horizontal position facing the equator at low light levels is conducive to the prevention of damages caused by storms and fast reaction to the increase in the amount of light at daybreak. A positive feature of the new system for PV power plant operators is that it performs the tracking of the sun practically without any decrease in power compared to the focal point position, since it works with an average inaccuracy of 1.9°.

Cherubism in three siblings. / A cherubismus elofordulása három testvérben.

Összefoglaló. A cherubismus ritka, autoszomális dominánsan öröklodo megbetegedés. A fibroossealis elváltozások csoportjába tartozik. Jellemzoje az állcsontok szimmetrikus duzzanata, a típusos radiológiai elváltozások és az SH3BP2-gén mutációja. Szövettanilag nem különül el az óriássejtes granulomától. A csontelváltozások és a fibroticus szövet felszaporodása pubertás elott kezdodik, ezután stagnálás vagy visszafejlodés következik be. A magyar orvosi irodalomban a szerzok elsoként tárgyalják három testvér kórtörténete alapján a cherubismust. A diagnózist a hasonló klinikai tünetek, a típusos kórlefolyás, a szinte azonos radiológiai kép, a szövettan és a genetikai elváltozások biztosítják. A testvérek és az anya csíravonalában kimutatott azonos mutáció akkor is megfelel egy dominánsan öröklodo szindrómának (például cherubismusnak), ha a betegség az anyában klinikailag nem manifesztálódott, de genetikailag igen. A szerzok összefoglalják a kórkép kezelési lehetoségeit: a sebészi (excochleatio, ,,decountouring", esetleg reszekció) és a gyógyszeres (biszfoszfonát, kalcitonin, szteroid stb.) terápiát. Egyezik a véleményük azokéval, akik azon az állásponton vannak, hogy a beavatkozásokkal várni kell, és meg kell figyelni a betegeket a várható regresszió miatt. Saját eseteikben csak a növekvo tumorrész excochleatióját végezték, foleg kozmetikai okok és a szövettan biztosítása érdekében. Orv Hetil. 2022; 163(11): 446-452. Summary. Cherubism is a rare autosomal, dominant bone disorder, characterised by symmetrical expansion of the jaws along the typical radiological and genetic (SH3BP2 mutation) features. It belongs to the heterogenous group of fibro-osseous lesions. Its histology is the same as that of giant-cell granuloma. The bone lesions and fibrous tissue expansion increase before puberty and regress thereafter. For the first time in Hungarian medical literature, the authors discuss the condition of cherubism in the case of three siblings. The diagnosis of these three siblings is supported by the clinical, radiological, microscopic and genetic data. In all three, the bone lesions and fibrous tissue expansion increased before puberty and stabilized thereafter. The radiological results and the molecular findings were nearly identical. The identical mutation shown in the germ lines of the three siblings and the mother correspond to a dominantly inherited syndrome (e.g., cherubism) even if the condition did not manifest in the mother. The authors summarize the treatment options of the disease: surgical (excochleation, decountouring, in rare case resection) and drug (bisphosphonate, calcitonin, steroid, etc.) therapy. They agree with those who are of the opinion that interventions should wait and the patients should be observed ("wait and see") for the expected regression. In their own cases, only excochleation of the growing tumor was performed, mainly for cosmetic reasons and to secure the tissue. Orv Hetil. 2022; 163(11): 446-452.

An Economic Analysis of the Shading Effects of Transmission Lines on Photovoltaic Power Plant Investment Decisions: A Case Study.

In today's photovoltaic (PV) power plants, traditional crystalline PV modules are the prevalent technology, which is highly susceptible to partial shading due to the risk of irreversible damage. Therefore, it is advisable to explore potential construction sites for objects that might cause shading, including high-voltage transmission towers, whose shading effects can be significant due to their height. By means of innovative simulation, using a model, validated with actual data, this study endeavored to deliver novel information related to the problems of shading by high-voltage transmission lines. In the context of Hungary, it examined the risk factors, technical and economic aspects, and possible solutions important for PV projects. It provides new insight, much needed also at the international level, considering the fact that the extent of the shadows cast by conductors on the surface at low Sun elevations is not known at present and neither are the shading characteristics of conductors between two transmission towers, depending on their height, in winter, when the Sun is low. An added practical benefit of the study is that its technical and economic approaches and the software solutions are all based on the practice of PV system design and construction. Related to the investigated issues, this can facilitate the formulation of the technical and economic aspects of suitable PV power plant building strategies in Hungary.

[Dental and oral surgical treatment of the mentally retarded in Hungary: the situation in the past, currently and hopes for the future]. / A szellemi fogyatékosok fogászati-szájsebészeti ellátásának múltja, jelene és remélt jövoje Magyarországon.

Introduction: Dental care for mentally disabled people poses a growing challenge for healthcare. In Hungary, the number of mentally disabled people needing special dental care is ca. 100 000. Aim: The aim of our retrospective analysis is to provide a summary of the demographic data and the treatment outcomes of patients with mental disorders treated at the Department of the Oral and Maxillofacial Surgery of the Semmelweis University in the past five years. Method: Dental care for patients with a severe level of mental disability can be carried out in general anaesthesia only. At Semmelweis University, in the Oral and Maxillofacial Department, 1717 mentally disabled adults received dental care during the past five years. (Patients included people with a mild, medium or severe level of mental disability, patients with Down's syndrome, autism, epilepsy or panic disorder.) Results: The single biggest achievement seems to be the fact that the issue of acute dental care and oral surgery has basically been settled. A workable relationship has been forged with foundations and organizations dealing with the problems of these patients. It has been realized, however, that in the case of mentally disabled patients there is an enormous need for prevention and ongoing care. Conclusions: Up to now no survey has been carried out in Hungary with the aim of objectively revealing the dental care needs of these patients. Internationally, however, several surveys have been published. It can be stated on the basis of these that both caries frequency and the presence of parodontal diseases increase in correlation with age and the level of disability. Oral hygiene is insufficient, patients or their caretakers do not get proper information, only a few of them receive adequate training and they are not motivated to keep up oral health. Dental care, except for tending acute cases, is not satisfactory. For the sake of prevention, cooperation is needed with non-governmental organizations, foundations, special education teachers and psychiatrists specialized in this field. Orv Hetil. 2019; 160(35): 1380-1386.

[Chronic, nonbacterial, multicentric osteomyelitis in the mandible]. / Krónikus, nem bakteriális, multicentrikus osteomyelitis a mandibulában.

Chronic nonbacterial osteomyelitis is a sterile inflammatory osteitis that most commonly develops in the long bones, but it can occur in any bone. Mandibular lesions are found in 1.5-3% of disease foci in patients and it is poorly characterized in the maxillofacial surgery literature due to the use of inconsistent terminology. The purpose of this study was to present the clinical experience of chronic nonbacterial multicentric osteomyelitis and a collection of research and information of the disease. This is a retrospective study of 2 cases with mandibular lesions radiographically consistent with osteomyelitis without infection. Medical records were reviewed for history, clinical features, imaging and pathology. The study included 2 patients (2 females, age of 17 and 43 years). Both reported mandibular pain and swelling, radiographic finding of multifocal intraosseal inflammatory lesions. Computed tomography scans typically showed expansion of the affected mandible with sclerosis of the medullary space, small foci of poorly defined lytic destruction with lamellated periosteal reaction. Both patients showed a long ineffective antibiotic therapy and recurrent flare-ups of inflammation. After the proper course of treatment (nonsteroid and steroid therapy), a long painless period was reached. Chronic multicentric nonbacterial osteomyelitis has been reported to be uncommon in the mandible, but it may be more common with correct diagnosis, typified by recurrent pain and swelling with characteristic pathologic and radiologic features. The current treatment modalities include nonsteroidal anti-inflammatory drugs or steroids. Orv Hetil. 2018; 159(43): 1761-1766.

In Situ Electron Microscopy of Lactomicroselenium Particles in Probiotic Bacteria.

Electron microscopy was used to test whether or not (a) in statu nascendi synthesized, and in situ measured, nanoparticle size does not differ significantly from the size of nanoparticles after their purification; and (b) the generation of selenium is detrimental to the bacterial strains that produce them. Elemental nano-sized selenium produced by probiotic latic acid bacteria was used as a lactomicroselenium (lactomicroSel) inhibitor of cell growth in the presence of lactomicroSel, and was followed by time-lapse microscopy. The size of lactomicroSel produced by probiotic bacteria was measured in situ and after isolation and purification. For these measurements the TESLA BS 540 transmission electron microscope was converted from analog (aTEM) to digital processing (dTEM), and further to remote-access internet electron microscopy (iTEM). Lactobacillus acidophilus produced fewer, but larger, lactomicroSel nanoparticles (200-350 nm) than Lactobacillus casei (L. casei), which generated many, smaller lactomicroSel particles (85-200 nm) and grains as a cloudy, less electrodense material. Streptococcus thermophilus cells generated selenoparticles (60-280 nm) in a suicidic manner. The size determined in situ in lactic acid bacteria was significantly lower than those measured by scanning electron microscopy after the isolation of lactomicroSel particles obtained from lactobacilli (100-500 nm), but higher relative to those isolated from Streptococcus thermopilus (50-100 nm). These differences indicate that smaller lactomicroSel particles could be more toxic to the producing bacteria themselves and discrepancies in size could have implications with respect to the applications of selenium nanoparticles as prebiotics.

External cooling efficiently controls intraosseous temperature rise caused by drilling in a drilling guide system: an in vitro study.

The purpose of this study was to measure the rise in intraosseous temperature caused by drilling through a drilling guide system. We compared the rise in temperature generated, and the number of increases of more than 10 °C, between drills that had been cooled with saline at room temperature (25 °C) and those that had not been cooled, for every step of the drilling sequence. Cortical layers of bovine ribs were used as specimens, and they were drilled through 3-dimensional printed surgical guides. Heat was measured with an infrared thermometer. The significance of differences was assessed with either a two-sample t test or Welch's test, depending on the variances. The mean rises (number of times that the temperature rose above 10 °C) for each group of measurements were: for the 2mm drill, 4.8 °C (0/48) when cooled and 7.0 °C (8/48) when not cooled; with the 2.5mm drill, 5.2 °C (1/48) when cooled and 8.5 °C (17/48) when not cooled (2 mm canal); with the 3 mm drill, 3.3 °C when cooled (0/48) and 8.5 °C (18/24) when not cooled (2.5 mm canal); and with the 3.5 mm drill, 4.8 °C when cooled (0/24) and 9.4 °C when not cooled (10/23) (3 mm canal). The temperature rose significantly less with cooling at every step of the drilling sequence (p<0.001). We conclude that external cooling can maintain the intraosseous temperature within the safe range while drilling through an implant guide system, whereas drilling without irrigation can lead to temperatures that exceed the acceptable limit.

The effect of systematic structural modifications on the antibacterial activity of novel oxazolidinones.

A novel series of tetraethylene glycol (TEG) triazolyl and squaramide containing oxazolidinones were synthesized and tested for their antibacterial activity against a selected panel of Gram-positive and Gram-negative bacteria. The 4-TEG-triazolyl derivatives were prepared by 'click reaction'. The introduction of the TEG and squaramide groups did not favor antibacterial activity. The three nucleoside-containing oxazolidinones were also prepared by 'click' methodology resulted in weak antibacterial activity.

Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity.

New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus.

Time-lapse analysis of cell death in mammalian and fungal cells.

Time-lapse video microscopy was designed to follow the movement of single cells for an unlimited period of time under physiological conditions. The system is based on two inverted microscopes located in a CO(2) incubator and equipped with charge-coupled device cameras connected to the computer. Frames were recorded every minute and the subsequent video sequence was converted to database form. The system was applied to describe the movements of normal HaCaT cells and Pb-treated cells causing the so-called apoptotic dance during cell death. The apoptotic movement was also followed in high-osmolarity glycerol-type mitogen-activated protein kinase (MAPK) null mutant of Fusarium proliferatum, a filamentous fungus, during osmotic stress. The shortest (20 min) and most vigorous death movements were observed in apoptotic fungal cells subjected to salt stress. The necrotic process at higher Pb concentration (50 microM) took 2-3 h, whereas the apoptotic process at lower Pb concentrations lasted from minutes to days.

Current problems in the surgical management of rectal cancer.

BACKGROUND/AIMS: Three issues associated with surgical treatment of rectal cancer are discussed in the present study. Necessity of standardisation of preoperative irradiation, based on interdisciplinary consensus is considered. The most urgent task is increasing the proportion of sphincter saving resections carried out by total mesorectal excision as related to the number of rectal exstirpations. The principles of surgical therapy of hepatic metastases of colorectal cancers are discussed. METHODOLOGY: The experience gathered from 328 radical resections performed during the years 1999-2002 is summed up. RESULTS: Three periods are compared; they managed to raise the proportion of surgical interventions preserving the rectal sphincter over 60%, during the last period the results have even further been improved. Total mesorectal excision performed by an atraumatic technique has been introduced and applied in their department. The rate of morbidity--28.8, 18.6 nd 5.3% for suture insufficiency--has been reduced. During the last eight years segment oriented liver resection indicated by the presence of hepatic metastasis has been performed in 20 instances. CONCLUSIONS: In addition to preoperative irradiation considered as necessary, the authors recommend treatment consisting of 5 x 5 Gy for early cancer, and of 60 Gy/6 weeks for advanced stages. In their opinion, application of atraumatic surgical techniques and up-to-date circular sewing machines can increase the proportion of sphincter preserving interventions securing the patient a better quality of life without abandoning the priciples of radicality. In their hope, the use of total mesorectal excision carried out adequately may reduce morbidity (suture insufficiency and nerve lesions--impaired innervation and sexual dysfunction) and the rate of local relapses and may improve survival. The only curative treatment of hepatic metastases of colorectal cancers is resection; therefore the authors raise the possibility of enlarging the range of surgical indications - more than three metastases in one lobe, bilateral affection.

Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding study.

Semisynthetic, lipophilic ristocetin and teicoplanin derivatives were prepared starting from ristocetin aglycon and teicoplanin psi-aglycon (N-acetyl-D-glucosaminyl aglycoteicoplanin). The terminal amino functions of the aglycons were converted into azido form by triflic azide. Copper catalyzed 1,3-dipolar cycloaddition reaction with lipophilic alkynes resulted in the title compounds. Two of the teicoplanin derivatives showed very good MIC and MBC values against various Gram-positive bacteria, including vanA enterococci. The aggregation and interaction of a n-decyl derivative with bacterial cell wall components was studied. One of the lipophilic ristocetin derivatives displayed favorable anti-influenza virus activity.

N-glycosylthioureido aglyco-ristocetins without platelet aggregation activity.

The water-soluble N-methoxy-PEG-yl-, N-beta-D-glucopyranosyl- and N-beta-D-maltosylthioureido aglyco-ristocetin were prepared which, in contrast to ristocetin A, did not induce thrombocyte aggregation. The antibacterial activity of N-beta-D-maltosylthioureido aglyco-ristocetin A against MRSA was comparable to that of ristocetin A, while its activity against Enterococcus faecalis (VRE, TSE) is somewhat stronger when compared to those of vancomycin and ristocetin A.

Supramolecular polymers based on the quadruplex formation of ditopic guanosine macromonomers in nonaqueous media.

The formation of supramolecular polymeric aggregates with a molecular mass of 100 kDa in a nonaqueous solution from a telechelic dimer of isopropylidene guanosine in the presence of K(+) ions is reported. The possible structure of macromonomers resulting from the development of G4 quartets was deduced from DOSY NMR, circular dichroism spectra, and dynamic light scattering measurements.

[Surgical aspects of breast cancer screening at our hospital]. / Az emloszures sebszeti vonatkozásai kórházunkban.

In addition to discussing effectiveness of breast cancer screening initiated within the National Public Health Programme, the problem of how to treat non-palpable, early invasive and in situ breast cancer (DCIS) is considered. The theoretical issue of the sentinel lymph node and its impact on biopsy practice have also been dealt with. In the authors' region, screening was introduced in 1999 and after a short break has been continued since 2002. Patient data of three periods, each of two years, each with ten years' interval (1982-1983, 1992-1993, 2002-2003) have been analysed. Changes in the number of surgical operations and tumour size, incidence of in situ cancer, lymph node involvement and distribution of types of surgery have been studied. Biopsy of the sentinel lymph node has been applied since May, 2003 (with 45 biopsies performed until 31 December, 2004). The number of persons participating in the screening programme has gradually increased, the number of surgical operations because of breast cancer increased from period to period. Size of the detected tumours has decreased, the percentage of non-palpable cases has been significant (445 surgical interventions during the years 2002-2004: surgery: 19%). The proportion of DCIS has increased to nearly four times as compared to data of years immediately preceding the era of screening (1993-1998: 11 cases, 2%; 1999-2004: 62 cases, 7.5%). Specificity of sentinel lymph node biopsy was 90%, with a sensitivity of 65%. The proportion of breast saving surgery has increased above 50%. The authors regard screening as successful, in their opinion, its benefits cannot be questioned, in spite of some controversial issues. As to the treatment of non-palpable, early invasive cancer, they underline the importance of preoperative evaluation--cytology, core biopsy--and establishing dignity. The issues of localisation--wire hook marking--and histological processing--large blocks--have also been dealt with. In spite of the fact that the risk for potential malignancy of DCIS lesions has not yet been fully clarified, adequate treatment is indicated; the authors take stand on the issues of indication for surgery, postoperative radiotherapy and use of Tamoxifen. Indications and contraindications of sentinel lymph node biopsy have been summed up.

Condensation of interphase chromatin in nuclei of synchronized chinese hamster ovary (CHO-K1) cells.

Reversibly permeabilized cells have been used to visualize interphase chromatin structures in the presence and absence of biotinylated nucleotides. By reversing permeabilization, it was possible to confirm the existence of a flexible chromatin folding pattern through a series of transient geometric forms such as supercoiled, circular forms, chromatin bodies, thin and thick fibers, and elongated chromosomes. Our results show that the incorporation of biotin-11-dUTP interferes with chromatin condensation, leading to the accumulation of decondensed chromatin structures. Chromatin condensation without nucleotide incorporation was also studied in cell populations synchronized by centrifugal elutriation. After reversal of permeabilization, nuclei were isolated and chromatin structures were visualized after DAPI staining by fluorescent microscopy. Decondensed veil-like structures were observed in the early S phase (at an average C-value of 2.21), supercoiled chromatin later in the early S (2, 55 C), fibrous structures in the early mid S phase (2, 76 C), ribboned structures in the mid-S phase (2, 98 C), continuous chromatin strings later in the mid-S phase (3,28), elongated prechromosomes in the late S-phase (3, 72 C), precondensed chromosomes at the end and after the S phase (3, 99 C). Fluorescent microscopy revealed that neither interphase nor metaphase chromosomes are separate entities but form a linear array arranged in a semicircle. Linear arrangement was confirmed by computer image analysis.

[Current issues in the surgical treatment of rectal cancer]. / Aktuális kérdések a rectum carcinoma sebészeti kezelésével kapcsolatban.

INTRODUCTION: Three topics associated with surgical treatment of rectal cancer are discussed. The need for standard preoperative irradiation, based on interdisciplinary approach is considered. In the authors' opinion the most urgent task is to increase the number of sphincter saving resections carried out by total mesorectal excision. The principles of surgical therapy for hepatic metastases are discussed. METHODS: The authors' experience is based on 328 radical resections performed between 1992-2003. RESULTS: Three periods are compared: we managed to raise the ratio of surgical interventions preserving the rectal sphincter over 60%, and during the last period the results have further improved. Total mesorectal excision is the standard in the department. The morbidity rate--28.8%, 18.6% and 5.3% for suture leak is reduced. During the last eight years in the presence of hepatic metastasis in 20 liver resections were performed. CONCLUSIONS: In addition to preoperative irradiation considered we recommend treatment consisting of 5x5 Gy for early cancer, and of 60 Gy/6 weeks for a progressed stage. In our opinion, application of atraumatic surgical techniques and up to date circular stapling guns can increase the ratio of sphincter preserving interventions. We hope, the use of total mesorectal excision carried out adequately may reduce morbidity (suture leak, nerve damage--impaired innervation and sexual dysfunction) and the rate of local recurrence and it may improve survival. The only curative treatment of hepatic metastases in colorectal cancers is resection, therefore the authors suggest the possibility of widening the range of surgical indications--more than three metastases in one lobe, even in bilateral involvement.