ABSTRACT
Objetivo: O presente trabalho buscou quantificar e classificar os dentes com reabsorções dentárias em indivíduos atendidos no Setor de Endodontia do Hospital de Reabilitação de Anomalias Craniofaciais (HRAC) da Universidade de São Paulo (USP). Foram feitas correlações entre o tipo de fissura de lábio e/ou palato e reabsorções dentárias, identificando o tipo de tratamento instituído e a prevalência de exodontia destes dentes. Material e Método: Foram analisados os prontuários de pacientes brasileiros que apresentavam algum tipo de fissura de lábio e/ou palato, cadastrados no HRAC, com idade entre 7 e 65 anos e atendidos no setorde Endodontia até o ano de 2006, buscando identificar algum dente com reabsorção dentária. Por meio da leitura e estudo das anotações ali contidas, os dados foram coletados e transferidos para uma ficha elaborada para esta pesquisa, sendo então submetidos à análise estatística pelo Teste Exato de Fisher, quando pertinente. Resultados: Foram incluídos na pesquisa 2404 prontuários. Destes, 71 apresentavam 91 dentes afetados por reabsorção dentária. Conclusões: Não houve relação entre os tipos de fissura de lábio e/ou palato e as reabsorções dentárias. Foram instituídos 64,8% de tratamentos endodônticos e 35,2% de proservações. A prevalência de exodontia foi de 35,2%.
Objective: The purpose of this research was quantify and classify teeth with root resorption from people treated at Endodontics?s department in Rehabilitation of Craniofacial Anomalies Hospital of University of São Paulo. The relationships between the type of cleft (lip and/or palate) and tooth resorption, identifying the treatment applied and the prevalence of extraction of these teeth were done. Material and Method: Medical recordsof Brazilian patients who had some type of cleft lip and/or palate registered at the hospital, aged between 7 and 65 years and treated in Department of Endodontics until the year 2006 were analyzed searching for teeth with root resorption. After reading and studying these information, data were collected and transferred to a spreadsheet prepared for this research, being analyzed statistically by Fisher?s Exact Test, when necessary. Results: The study included 2404 medical records. From these, 71 patients have shown 91 teeth with tooth resorption. Conclusions: There was no relationship between the types of cleft (lipand/or palate) and tooth resorption. It was determined 64.8 % of endodontic treatments and 35.2 % of follow ups. The prevalence of extraction was 35.2 %.
ABSTRACT
OBJECTIVE: The objective of this study was to determine the expression of matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) during apical periodontitis development. METHODS: Using an experimental design of induced periapical lesions in rats and immunohistochemistry assay as investigative tool, the MMP-2 and MMP-9 expression and distribution were evaluated at 3, 7, 14, 21, 30, 60 and 90 days after coronary access and pulp exposure of the first left mandibular molar to the oral environment. Two blind observers scored the immunoreactivity. A semi-quantitative analysis was performed. RESULTS: Except at day 3, MMP-2 and MMP-9 immunostaining was observed in all experimental periods. The MMP-2 (p=0.004) and MMP-9 (p=0.005) immunostaining was higher in the period between 7 and 21 days. They were mainly observed in cells surrounding the apical foramen and adjacent periapical areas. Cells into the hypercementosis areas were strongly stained while both osteoblasts and osteoclasts presented discrete staining along of this study. No staining was observed on epithelial walls. At 30, 60 and 90 days, the subjacent connective tissue presented intense MMP-2 and MMP-9 immunostaining in mononuclear cells (suggestive of fibroblasts, macrophages, infiltrating neutrophils and lymphocytes). CONCLUSION: The results observed in this study suggest that MMP-2 and MMP-9 play a critical role in the development of inflammatory periapical lesions, probably involved in the extracellular matrix (ECM) degradation during the initial phase of the lesion development.