ABSTRACT
Pregnancy alters the pharmacokinetic properties of many antimalarial compounds. The objective of this study was to evaluate the pharmacokinetic properties of lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Uganda after a standard fixed oral artemether-lumefantrine treatment. Dense venous (n = 26) and sparse capillary (n = 90) lumefantrine samples were drawn from pregnant patients. A total of 17 nonpregnant women contributed with dense venous lumefantrine samples. Lumefantrine pharmacokinetics was best described by a flexible absorption model with multiphasic disposition. Pregnancy and body temperature had a significant impact on the pharmacokinetic properties of lumefantrine. Simulations from the final model indicated 27% lower day 7 concentrations in pregnant women compared with nonpregnant women and a decreased median time of 0.92 and 0.42 days above previously defined critical concentration cutoff values (280 and 175 ng/ml, respectively). The standard artemether-lumefantrine dose regimen in P. falciparum malaria may need reevaluation in nonimmune pregnant women.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e83; doi:10.1038/psp.2013.59; advance online publication 13 November 2013.
Subject(s)
Refugees/statistics & numerical data , Cause of Death , Child, Preschool , Female , Humans , Measles/mortality , Mortality , Uganda/epidemiologySubject(s)
Lymphocyte Subsets/cytology , Purpura, Thrombocytopenic, Idiopathic/blood , Purpura, Thrombocytopenic, Idiopathic/surgery , Adult , Cohort Studies , Female , Follow-Up Studies , Humans , Immunophenotyping , Lymphocyte Activation , Lymphocyte Count , Lymphocyte Subsets/immunology , Male , Purpura, Thrombocytopenic, Idiopathic/immunology , SplenectomyABSTRACT
PSA has been measured out with highly sensitive method both in liquid of mammary cysts and in cytosol of neoplastic cells. Our data point out that dysplastic, metaplastic and anaplastic breast epithelial cells produce PSA. Such production is, probably, related to expression of hormonal receptors.
Subject(s)
Adenocarcinoma/metabolism , Breast Neoplasms/metabolism , Prostate-Specific Antigen/metabolism , Biomarkers , Cytosol/chemistry , Endothelium/metabolism , Female , Fibrocystic Breast Disease/metabolism , Humans , Prostate-Specific Antigen/analysis , Radioimmunoassay , Sensitivity and SpecificityABSTRACT
The authors describe a group of twenty elderly patients with pyramidal-extrapyramidal rigidity treated daily for three months with TRH-T. The incidence of side-effects was low and only one drop-out is reported. Most of the patients treated improved their scores on the NUDS Scale and Webster Scale.
Subject(s)
Basal Ganglia Diseases/drug therapy , Muscle Rigidity/drug therapy , Thyrotropin-Releasing Hormone/therapeutic use , Age Factors , Aged , Aged, 80 and over , Drug Evaluation , Female , Humans , Male , Muscle Rigidity/diagnosis , Muscle Rigidity/etiology , Thyrotropin-Releasing Hormone/administration & dosage , Time FactorsABSTRACT
A case of nontraumatic dissecting aneurysm of the basilar artery in association with hypertension, smoke, and oral contraceptives is reported in a young female patient with a locked-in syndrome.
