[Effect of cigarette smoking on exhaled nitric oxide levels in healthy volunteers and patients with coronary heart disease]. / Wplyw palenia tytoniu na stezenia wydychanego tlenku azotu u zdrowych ochotników i pacjentów z choroba wiencowa.

UNLABELLED: Exhaled air contains nitric oxide in very low concentrations reaching several parts per billion. There are many factors which can influence exhaled nitric oxide levels (eNO), one of them is cigarette smoking. MATERIAL AND METHODS: We investigated 78 patients: Group I (n = 26)--smokers, divided in two subgroups--I A healthy volunteers (n = 13) and I B--patients with coronary heart disease (CAD) (n = 13) Group II (n = 52)--nonsmokers. They were also divided in two subgroups--II A healthy volunteers (n = 21) and II B patients with CAD taking nitrates orally (n = 31) We use NO analyzer NOA 280 (Sievers Boulder Col. USA) with chemo-luminescence method RESULTS: We found that eNO levels were significantly lower in smoking group than in nonsmokers. This fact was noticed in whole investigated population and in both subgroups, CONCLUSION: 1. Cigarette smoking significantly lowers exhaled nitric oxide levels and should be always taken into account during interpretation of the results. 2. Cigarette smoking significantly lowers exhaled nitric oxide levels even with of oral nitrates therapy.