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1.
Biochim Biophys Acta Mol Basis Dis ; 1866(6): 165722, 2020 06 01.
Article in English | MEDLINE | ID: mdl-32057941

ABSTRACT

It is increasingly recognized that sex and gender differences (S&G) influence cardiovascular diseases (CVD), greatly impacting disease management. In terms of definition, sex refers to biological aspects, gender effects being mainly related to socio-cultural factors. Both sex and gender are interpenetrated in humans and difficult to separate. This is more clearly feasible in animal models where sex effects largely predominate. As alterations in energy metabolism are essential features of cardiovascular diseases, sexual dimorphism of energy metabolism and more specifically mitochondria occupies a place of choice. This review presents the basis of sex and gender differences in the cardiovascular pathophysiology, and how it mainly affects woman diseases, effectiveness of therapies and clinical outcome. These differences rely on complex molecular mechanisms that are still poorly understood because of the under-representation of females/women in experimental and clinical studies. Finally, the differing psychological and biological phases of woman's life are largely underestimated. This review presents an overview of the field with focus on differences in cardiac energy metabolism, which are illustrated with specific examples.


Subject(s)
Cardiovascular Diseases/epidemiology , Energy Metabolism , Heart/physiopathology , Cardiovascular Diseases/physiopathology , Female , Humans , Interpersonal Relations , Male , Mitochondria/metabolism , Risk Factors , Sex Characteristics
2.
J Physiol ; 591(23): 6017-37, 2013 Dec 01.
Article in English | MEDLINE | ID: mdl-24042504

ABSTRACT

The role of OPA1, a GTPase dynamin protein mainly involved in the fusion of inner mitochondrial membranes, has been studied in many cell types, but only a few studies have been conducted on adult differentiated tissues such as cardiac or skeletal muscle cells. Yet OPA1 is highly expressed in these cells, and could play different roles, especially in response to an environmental stress like exercise. Endurance exercise increases energy demand in skeletal muscle and repeated activity induces mitochondrial biogenesis and activation of fusion-fission cycles for the synthesis of new mitochondria. But currently no study has clearly shown a link between mitochondrial dynamics and biogenesis. Using a mouse model of haploinsufficiency for the Opa1 gene (Opa1(+/-)), we therefore studied the impact of OPA1 deficiency on the adaptation ability of fast skeletal muscles to endurance exercise training. Our results show that, surprisingly, Opa1(+/-) mice were able to perform the same physical activity as control mice. However, the adaptation strategies of both strains after training differed: while in control mice mitochondrial biogenesis was increased as expected, in Opa1(+/-) mice this process was blunted. Instead, training in Opa1(+/-) mice led to an increase in endurance capacity, and a specific adaptive response involving a metabolic remodelling towards enhanced fatty acid utilization. In conclusion, OPA1 appears necessary for the normal adaptive response and mitochondrial biogenesis of skeletal muscle to training. This work opens new perspectives on the role of mitochondrial dynamics in skeletal muscle cells and during adaptation to stress.


Subject(s)
GTP Phosphohydrolases/physiology , Mitochondria, Muscle/physiology , Muscle, Skeletal/physiology , Physical Conditioning, Animal/physiology , Physical Endurance/physiology , Animals , Behavior, Animal/physiology , DNA/metabolism , Male , Mice , Mice, Knockout , Microscopy, Electron , Mitochondria, Muscle/ultrastructure , Psychomotor Performance/physiology , Running
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