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Comb Chem High Throughput Screen ; 21(7): 526-532, 2018.
Article in English | MEDLINE | ID: mdl-30152280

ABSTRACT

AIM AND OBJECTIVE: In this work, we synthesized and characterized a novel Brönsted acidic ionic liquid from the reaction of N, N, N', N'-tetramethylethylenediamine with chlorosulfonic acid and explored its catalytic activity in 1, 8-dioxo-octahydroxanthenes synthesis. MATERIALS AND METHODS: Dimedone, aryl aldehydes, and the ionic liquid as the catalyst were reacted under solvent-free conditions. The progressive of the reaction was monitored by a thin layer of chromatography (ethyl acetate/n-hexane = 1/5). All products were characterized as the basis of their spectra data and melting point by comparison with those reported in the literature. RESULTS: The prepared ionic liquid was successfully applied in the synthesis of 1, 8-dioxooctahydroxanthenes in good to high yields on the reaction of aryl aldehyde and dimedone at 120°C under solvent-free conditions. CONCLUSION: This research demonstrates that the catalyst is impressive for 1, 8-dioxo-octahydroxanthenes synthesis under solvent-free conditions.


Subject(s)
Ethylenediamines/chemistry , Ionic Liquids/chemistry , Xanthenes/chemical synthesis , Ethylenediamines/chemical synthesis , High-Throughput Screening Assays , Ionic Liquids/chemical synthesis , Molecular Structure , Xanthenes/chemistry
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