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Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial.

Dileone, Michele; Ammann, Claudia; Catanzaro, Valentina; Pagge, Cristina; Piredda, Rosanna; Monje, Mariana H G; Navalpotro-Gomez, Irene; Bergareche, Alberto; Rodríguez-Oroz, María Cruz; Vela-Desojo, Lydia; Alonso-Frech, Fernando; Catalán, María J; Molina, José A; López-Ariztegu, Nuria; Oliviero, Antonio; Obeso, José A; Foffani, Guglielmo.

Brain Stimul ; 15(3): 857-860, 2022.

Article in English | MEDLINE | ID: mdl-35609815

Subject(s)

Dyskinesia, Drug-Induced , Motor Cortex , Parkinson Disease , Dyskinesia, Drug-Induced/etiology , Dyskinesia, Drug-Induced/therapy , Humans , Levodopa/adverse effects , Magnetic Fields , Parkinson Disease/therapy

Clinical Reasoning: A 58-year-old man with hand tremor and episodes of neck pain.

Urso, Daniele; Monje, Mariana H G; Piredda, Rosanna; Ortu, Renato; Pineda-Pardo, José A; Martínez-Fernández, Raul; Sechi, GianPietro.

Neurology ; 93(12): 557-561, 2019 09 17.

Article in English | MEDLINE | ID: mdl-31527099

Subject(s)

Hand , Neck Pain/diagnosis , Parkinson Disease/diagnosis , Tremor/diagnosis , alpha-Synuclein , Diagnosis, Differential , Hand/pathology , Humans , Male , Middle Aged , Neck Pain/etiology , Neck Pain/genetics , Parkinson Disease/complications , Parkinson Disease/genetics , Tremor/etiology , Tremor/genetics , alpha-Synuclein/genetics

Cognitive safety after unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor.

Gasca-Salas, Carmen; Guida, Pasqualina; Piredda, Rosanna; Obeso, Ignacio; Vela Desojo, Lydia; Martínez-Fernández, Raúl; Hernández-Fernández, Frida; Máñez-Miró, Jorge; Pineda-Pardo, José A; Del Álamo, Marta; Rodriguez-Rojas, Rafael; Mata-Marín, David; Alonso-Frech, Fernando; de Luis, Esther; Obeso, Jose Angel.

J Neurol Neurosurg Psychiatry ; 90(7): 830-831, 2019 07.

Article in English | MEDLINE | ID: mdl-30850471

Subject(s)

Cognition , Essential Tremor/surgery , Ventral Thalamic Nuclei/surgery , Female , Humans , Magnetic Resonance Imaging, Interventional/methods , Male , Middle Aged , Neuropsychological Tests , Ultrasonography, Interventional/methods

Longitudinally Extensive Spinal Cord Lesions Disclosing Occult Systemic Sarcoidosis.

Sechi, Elia; Addis, Alberto; Piredda, Rosanna; Rassu, Anna Laura; Mameli, GianFranco; Senes, Chiara; Sechi, GianPietro.

JAMA Neurol ; 73(5): 600-1, 2016 05 01.

Article in English | MEDLINE | ID: mdl-26974505

Subject(s)

Sarcoidosis/complications , Sarcoidosis/diagnostic imaging , Spinal Cord Diseases/complications , Spinal Cord Diseases/diagnostic imaging , Adult , Humans , Lymph Nodes/pathology , Magnetic Resonance Imaging , Male , Neurologic Examination , Tomography Scanners, X-Ray Computed

Humoral cross reactivity between α-synuclein and herpes simplex-1 epitope in Parkinson's disease, a triggering role in the disease?

Caggiu, Elisa; Paulus, Kai; Arru, Giannina; Piredda, Rosanna; Sechi, Gian Pietro; Sechi, Leonardo A.

J Neuroimmunol ; 291: 110-4, 2016 Feb 15.

Article in English | MEDLINE | ID: mdl-26857504

ABSTRACT

Environmental factors are implicated in the development of Parkinson's disease (PD). We have investigated on the role of molecular mimicry between HSV1 and α-synuclein that could foster the progression of PD. The antibody response against homologous peptides in PD patients and healthy controls was evaluated, showing that these antibodies are highly prevalent among PD patients to healthy controls. The competitive assay demonstrated cross-reactivity between HSV1 and human α-synuclein peptides. The results may suggest the hypothesis of the involvement of HSV1 in stimulating the immune cells against the neurons of the substantia nigra as a consequence of the cross reactivity.

Subject(s)

Herpes Simplex Virus Protein Vmw65/metabolism , Parkinson Disease/complications , alpha-Synuclein/metabolism , Aged , Case-Control Studies , Cross Reactions , Enzyme-Linked Immunosorbent Assay , Female , Humans , Male , Middle Aged , Molecular Mimicry , Peptides/metabolism , ROC Curve , Substantia Nigra/metabolism , Substantia Nigra/pathology

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