Is the learning curve of the urology resident for conventional radical prostatectomy similar to that of staff initiating robot-assisted radical prostatectomy?

ABSTRACT Introduction: The superiority of the functional results of robot-assisted radical prostatectomyis still controversial. Despite this, it is known that minimally invasive surgery obtains better results when analyzing blood loss, blood transfusion and length of stay, for example. Several studies have analyzed the impact of the resident physician's involvement on the results of urological surgeries. The simple learning curve for robot-assisted radical prostate surgery is estimated to be around 10 to 12 cases. Learning curve data for robotic surgeons is heterogeneous, making it difficult to analyze. Rare studies compare the results of a radical prostatectomy of an inexperienced surgeon starting his training in open surgery, with the results of the same surgeon, a few years later, starting training in robotic surgery. Objective: to analyze the results of open radical prostatectomy surgeries (ORP) performed by urology residents, comparing them to the results of robot-assisted radical prostatectomy (RARP), performed by these same surgeons, after completing their training in urology. Materials and methods: a retrospective analysis of the cases of only 3 surgeons was performed. 50 patients underwent ORP (group A). The surgeons who operated on the ORP patients were in the 3rd and final year of the urology residency program and beginners in ORP surgery, but with at least 4 years of experience in open surgery. The same surgeons, already trained urologists, began their training in robotic surgery and performed 56 RARP surgeries (group B). For the comparative analysis, data were collected on age, number of lymph nodes removed, surgery time, hospitalization time, drain volume, drain permanence time, indwelling bladdercateter (IBC) permanence time, positive surgical margin, biochemical recurrence, risk classification (ISUP), intra and postoperative complications, urinary incontinence (UI) and erectile dysfunction (ED). The console used was the Da Vinci Si, from Intuitive®. For statistical analysis, the Shapiro-Wilk test verified that the data did not follow normality, the Levene test guaranteed homogeneity, and the Mann-Whitney test performed the comparative analysis of the quantitative data. For the analysis of qualitative data, the Chi-square test was used for nominal variables and the Mann-Whitney U test for ordinal variables. Additionally, the Friedman test analyzed whether there was an improvement in the perception of UI or ED over the months, for each group individually (without comparing them), and the post-hoc Durbin-Conover test, for the results with statistically significant difference. We used a p-value < 0.05, and the Jamovi® program (Version 2.0). Results: there was no statistically significant difference between the groups for age, number of lymph nodes removed, positive surgical margin, biochemical recurrence, risk classification and urinary incontinence. Additionally, we observed that the surgical time was longer in group B. On the other hand, the length of stay, drain volume, drain time, IBC time, complication rate and levels of erectile dysfunction in the third and sixth months were higher in group A, when compared to group B. We also observed that there was no evolutionary improvement in ED over the months in both groups, and that there was a perception of improvement in UI from the 1st to the 3rd month in group A, and from the 1st to the 6th month, and from the 3rd to the 12th month, in group B. Conclusion: the learning curve of RARP is equivalent to the curve of ORP. In general, the results for the robotic group were better, however, the functional results were similar between the groups, with a slight tendency of advantage for the robotic arm.

Structural conversion of the spidroin C-terminal domain during assembly of spider silk fibers.

The major ampullate Spidroin 1 (MaSp1) is the main protein of the dragline spider silk. The C-terminal (CT) domain of MaSp1 is crucial for the self-assembly into fibers but the details of how it contributes to the fiber formation remain unsolved. Here we exploit the fact that the CT domain can form silk-like fibers by itself to gain knowledge about this transition. Structural investigations of fibers from recombinantly produced CT domain from E. australis MaSp1 reveal an α-helix to ß-sheet transition upon fiber formation and highlight the helix No4 segment as most likely to initiate the structural conversion. This prediction is corroborated by the finding that a peptide corresponding to helix No4 has the ability of pH-induced conversion into ß-sheets and self-assembly into nanofibrils. Our results provide structural information about the CT domain in fiber form and clues about its role in triggering the structural conversion of spidroins during fiber assembly.

"You only have one mother!": institutional violence in experiences of double motherhood in healthcare. / "Mãe é só uma!": violência institucional nas experiências de dupla maternidade na atenção à saúde.

The objective was to understand experiences of double motherhood during antenatal, childbirth and postpartum healthcare, using a qualitative method involving individual online interviews and asynchronous, online focus groups of cisgender women, mostly in same-sex relationships. The results revealed how these women's experiences of parenting were marginalised, highlighting institutional violence in Brazilian healthcare services, which are presented here in two thematic dimensions: 1) Cisheteronormativity and its impact on experiences of double motherhood; and 2) Institutional violence in healthcare services: from curiosity to LGBTQIA+phobia. It was concluded that cisheteronormativity hinders healthcare for these experiences, especially by rendering the non-gestational mother invisible. This underscores the urgent need to train healthcare personnel, rethink and challenge cisgender and heterosexual norms and promote inclusive policies to ensure equitable care and combat institutional violence.

Objetivou-se compreender as experiências de dupla maternidade na atenção à saúde durante o pré-natal, parto e puerpério a partir de um método qualitativo, utilizando entrevistas individuais on-line e grupo focal on-line assíncrono com mulheres cisgêneros, a maioria em relacionamentos homoafetivos. Os resultados revelaram a marginalização das vivências parentais dessas mulheres, destacando a violência institucional presente nos serviços de saúde brasileiros, sendo apresentados em dois eixos temáticos: 1) Cisheteronormatividade e seu impacto nas experiências de dupla maternidade e 2) Violência institucional nos serviços de saúde: da curiosidade à LGBTQIA+fobia. Conclui-se que a cisheteronormatividade prejudica a atenção à saúde para essas experiências, especialmente ao invisibilizar a mãe não gestante, destacando a urgência de capacitar profissionais de saúde, repensar e desafiar as normas cisgênero e heterossexuais e promover políticas inclusivas para garantir cuidados equitativos e combater a violência institucional.

Is the learning curve of the urology resident for conventional radical prostatectomy similar to that of staff initiating robot-assisted radical prostatectomy?

INTRODUCTION: The superiority of the functional results of robot-assisted radical prostatectomyis still controversial. Despite this, it is known that minimally invasive surgery obtains better results when analyzing blood loss, blood transfusion and length of stay, for example. Several studies have analyzed the impact of the resident physician's involvement on the results of urological surgeries. The simple learning curve for robot-assisted radical prostate surgery is estimated to be around 10 to 12 cases. Learning curve data for robotic surgeons is heterogeneous, making it difficult to analyze. Rare studies compare the results of a radical prostatectomy of an inexperienced surgeon starting his training in open surgery, with the results of the same surgeon, a few years later, starting training in robotic surgery. OBJECTIVE: to analyze the results of open radical prostatectomy surgeries (ORP) performed by urology residents, comparing them to the results of robot-assisted radical prostatectomy (RARP), performed by these same surgeons, after completing their training in urology. MATERIALS AND METHODS: a retrospective analysis of the cases of only 3 surgeons was performed. 50 patients underwent ORP (group A). The surgeons who operated on the ORP patients were in the 3rd and final year of the urology residency program and beginners in ORP surgery, but with at least 4 years of experience in open surgery. The same surgeons, already trained urologists, began their training in robotic surgery and performed 56 RARP surgeries (group B). For the comparative analysis, data were collected on age, number of lymph nodes removed, surgery time, hospitalization time, drain volume, drain permanence time, indwelling bladdercateter (IBC) permanence time, positive surgical margin, biochemical recurrence, risk classification (ISUP), intra and postoperative complications, urinary incontinence (UI) and erectile dysfunction (ED). The console used was the Da Vinci Si, from Intuitive®. For statistical analysis, the Shapiro-Wilk test verified that the data did not follow normality, the Levene test guaranteed homogeneity, and the Mann-Whitney test performed the comparative analysis of the quantitative data. For the analysis of qualitative data, the Chi-square test was used for nominal variables and the Mann-Whitney U test for ordinal variables. Additionally, the Friedman test analyzed whether there was an improvement in the perception of UI or ED over the months, for each group individually (without comparing them), and the post-hoc Durbin-Conover test, for the results with statistically significant difference. We used a p-value < 0.05, and the Jamovi® program (Version 2.0). RESULTS: there was no statistically significant difference between the groups for age, number of lymph nodes removed, positive surgical margin, biochemical recurrence, risk classification and urinary incontinence. Additionally, we observed that the surgical time was longer in group B. On the other hand, the length of stay, drain volume, drain time, IBC time, complication rate and levels of erectile dysfunction in the third and sixth months were higher in group A, when compared to group B. We also observed that there was no evolutionary improvement in ED over the months in both groups, and that there was a perception of improvement in UI from the 1st to the 3rd month in group A, and from the 1st to the 6th month, and from the 3rd to the 12th month, in group B. CONCLUSION: the learning curve of RARP is equivalent to the curve of ORP. In general, the results for the robotic group were better, however, the functional results were similar between the groups, with a slight tendency of advantage for the robotic arm.

"Mãe é só uma!": violência institucional nas experiências de dupla maternidade na atenção à saúde / "You only have one mother!": institutional violence in experiences of double motherhood in healthcare

Resumo Objetivou-se compreender as experiências de dupla maternidade na atenção à saúde durante o pré-natal, parto e puerpério a partir de um método qualitativo, utilizando entrevistas individuais on-line e grupo focal on-line assíncrono com mulheres cisgêneros, a maioria em relacionamentos homoafetivos. Os resultados revelaram a marginalização das vivências parentais dessas mulheres, destacando a violência institucional presente nos serviços de saúde brasileiros, sendo apresentados em dois eixos temáticos: 1) Cisheteronormatividade e seu impacto nas experiências de dupla maternidade e 2) Violência institucional nos serviços de saúde: da curiosidade à LGBTQIA+fobia. Conclui-se que a cisheteronormatividade prejudica a atenção à saúde para essas experiências, especialmente ao invisibilizar a mãe não gestante, destacando a urgência de capacitar profissionais de saúde, repensar e desafiar as normas cisgênero e heterossexuais e promover políticas inclusivas para garantir cuidados equitativos e combater a violência institucional.

Abstract The objective was to understand experiences of double motherhood during antenatal, childbirth and postpartum healthcare, using a qualitative method involving individual online interviews and asynchronous, online focus groups of cisgender women, mostly in same-sex relationships. The results revealed how these women's experiences of parenting were marginalised, highlighting institutional violence in Brazilian healthcare services, which are presented here in two thematic dimensions: 1) Cisheteronormativity and its impact on experiences of double motherhood; and 2) Institutional violence in healthcare services: from curiosity to LGBTQIA+phobia. It was concluded that cisheteronormativity hinders healthcare for these experiences, especially by rendering the non-gestational mother invisible. This underscores the urgent need to train healthcare personnel, rethink and challenge cisgender and heterosexual norms and promote inclusive policies to ensure equitable care and combat institutional violence.

Construções de masculinidades entre pessoas moradoras de rua: uma revisão de escopo / Constructions of masculinity among homeless persons: a scoping review

Resumo Nesta revisão objetivou-se investigar e sintetizar o que há na literatura científica sobre as relações entre as masculinidades e as pessoas moradoras de rua, com enfoque em relações sociais, trajetória e processo saúde-doença. Foi feita uma busca sistemática em dez bases de dados com os descritores: "Masculinities", "Hegemonic Masculinities", "Gender Identity" e "Homeless Persons", "Homeless, Roofless" e "Houseless". Obteve-se 2.459 resultados, com 25 referências finais após aplicação dos critérios de inclusão e exclusão, compostas em grande parte por estudos internacionais. Identificou-se seis temas-chave: Masculinidade enquanto prática performativa nas ruas, Masculinidades e relações de violência nas ruas, Masculinidades entre homens moradores de rua: percepções de liberdade e encarceramento, Paternidade dos homens moradores de rua, Estigmas e deságios no processo de busca pela masculinidade hegemônica nas ruas e Masculinidades como determinante social de saúde nas ruas. A revisão aborda as influências das masculinidades entre a População Moradora de Rua (PMR), destacando sua transversalidade nas vivências e atitudes do grupo, e explora a relação entre masculinidades e violência, os desafios na paternidade e os estigmas ligados à condição de vida nas ruas e impactos na saúde. Conclui-se que as normas sociais relacionadas ao masculino atuam como uma forma de se adaptar as vidas nas ruas, mas influenciam negativamente no processo saúde-doença da PMR, em especial dos homens.

Abstract This study aimed to investigate and synthesize the scientific literature regarding the relationships between masculinities and individuals experiencing homelessness by focusing on social relationships, life trajectories, and the health-disease process. A systematic search was conducted in 10 databases using the following descriptors: "Masculinities," "Hegemonic Masculinities," "Gender Identity," "Homeless Persons," "Homeless, Roofless," and "Houseless." In total, 2459 results were retrieved. Overall, 25 studies remained after the application of inclusion and exclusion criteria, most of which were international studies. This study identified six key themes: 1) Masculinity as a performative practice on the streets, 2) Masculinities and relationships of violence on the streets, 3) Masculinities among men experiencing homelessness: perceptions of freedom and imprisonment, 4) Fatherhood among men experiencing homelessness, 5) Stigmas and challenges in the pursuit of hegemonic masculinity on the streets, and 6) Masculinities as a social determinant of health on the streets. This review addresses the influences of masculinities on individuals experiencing homelessness, emphasizing the cross-cutting nature of these ideals in the experiences and attitudes of this group. It explores the relationship between masculinities and violence, as well as addressing challenges in fatherhood. It highlights stigmas linked to the condition of being homeless that impact health and quality of life. It is concluded that social norms related to masculinity act negatively as social determinants of health for the homeless population, especially men.

Food protein-derived amyloids do not accelerate amyloid ß aggregation.

The deposition of proteins in the form of amyloid fibrils is closely associated with several serious diseases. The events that trigger the conversion from soluble functional proteins into insoluble amyloid are not fully understood. Many proteins that are not associated with disease can form amyloid with similar structural characteristics as the disease-associated fibrils, which highlights the potential risk of cross-seeding of disease amyloid by amyloid-like structures encountered in our surrounding. Of particular interest are common food proteins that can be transformed into amyloid under conditions similar to cooking. We here investigate cross-seeding of amyloid-ß (Aß), a peptide known to form amyloid during the development of Alzheimer's disease, by 16 types of amyloid fibrils derived from food proteins or peptides. Kinetic studies using thioflavin T fluorescence as output show that none of the investigated protein fibrils accelerates the aggregation of Aß. In at least two cases (hen egg lysozyme and oat protein isolate) we observe retardation of the aggregation, which appears to originate from interactions between the food protein seeds and Aß in aggregated form. The results support the view that food-derived amyloid is not a risk factor for development of Aß pathology and Alzheimer's disease.

A formação de estudantes de Medicina para o cuidado destinado à saúde de pessoas LGBTI+ / The training of Medical students to health care of LGBTI+ people

Resumo: Introdução: A Política Nacional de Saúde Integral de Lésbicas, Gays, Bissexuais, Travestis e Transexuais (PNSILGBT) é formada por um agrupamento de diretrizes e planos, sendo um eixo importante para formação dos profissionais de saúde, por meio de ações e estratégias específicas, para minimizar os efeitos da discriminação de gênero e sexualidade de uma população historicamente marginalizada. Na literatura, encontram-se estudos que evidenciam a falta de carga horária específica para gênero e sexualidade, a falta de transversalidade da temática LGBTI+ ou ainda a ausência da abordagem de aspectos socioeconômicos, políticos e raciais da saúde LGBTI+ dentro dos currículos de Medicina no Brasil e no mundo. Objetivo: Este estudo teve como objetivo comparar a percepção entre discentes assumidamente LGBTI+ e discentes heterossexuais no que concerne à formação dos médicos sobre a saúde de minorias sexuais e de gênero. Método: Trata-se de um estudo qualitativo, em profundidade, com análise de discurso de grupos focais, um com alunos LGBTI+ e outro com alunos não LGBTI+, em que se aplicou um questionário semiestruturado com base na análise de práticas discursivas de Spink. Resultado: A análise dos grupos identificou como questões mais pertinentes: pouca carga horária programática; falta de transversalidade; abordagem do tema com olhar pejorativo e preconceituoso; associação da população LGBTI+ com doenças infectocontagiosas ou psiquiátricas; ausência de abordagem dos aspectos socioeconômicos, culturais e raciais da temática; e atenção primária à saúde como espaço de maior abertura para discussões sobre gênero e sexualidade; Conclusão: Há uma percepção, em ambos os grupos, de que o ensino de saúde LGBTI+ é insuficiente e há um despreparo dos alunos para a abordagem da temática de gênero e sexualidade, o que gera impacto direto na assistência em saúde dessa população. Além disso, são necessários mais estudos sobre educação médica em saúde LGBTI+.

Abstract: Introduction: Brazil national public policy for the comprehensive healthcare of the LGBTi+ population consists of several guidelines and plans that include the training of health professionals. Through actions and strategies, it aims to minimize the effects of gender and sexuality discrimination on this historically marginalized population. Studies were found that show a lack of specific hours for gender and sexuality, a lack of transversality of the LGBTI+ topic and a lack of addressing the socioeconomic, political and racial aspects of LGBTI+ health in the curricula of Faculties of Medicine in Brazil and in the world. Objective: To compare the perception between admittedly LGBTI+ students and heterosexual students regarding the training of medical students on the health of sexual and gender minorities. Methodology: An in-depth qualitative study was carried out through two focus groups: one with LGBTI+ students and the other with non-LGBTI+ students. In addition, a semi-structured questionnaire was also applied. The analysis was made through the analysis of Spink's Discursive Practices. Result: Current problems were identified: low number of programmatic hours on the topic; lack of transversality; addressing the topic through a pejorative and prejudiced look; association of LGBTI+ people with infectious or psychiatric diseases; lack of addressing socioeconomic, cultural and racial aspects; Primary Care as a space of greater openness to fight against the cisheteronormative hegemony; Conclusion: LGBTI+ health education is still insufficient, as students feel unprepared to address the issue of gender and sexuality, which directly impacts the healthcare of this population. Additionally, further studies on medical education in LGBTI+ health are needed.

"Desculpe a demora!": métodos online como estratégia para desenvolvimento de pesquisas sobre maternidades / "Sorry for the delay!": online methods as a strategy for developing research on maternity

Resumo A partir da experiência de pesquisa com mulheres mães lésbicas e bissexuais e das dificuldades encontradas para realização de encontros síncronos para a coleta de dados, observou-se que métodos de pesquisa online assíncronos se apresentam como estratégias em potencial para esse grupo em específico, considerado de difícil acesso. Este trabalho visa retratar o percurso metodológico para desenvolvimento de pesquisa exploratória, com abordagem qualitativa, desenvolvida por meio de métodos online, utilizando-se de estratégias como entrevistas abertas e grupo focal online, por meio da mídia social WhatsApp.

Abstract From a research experience with lesbian and bisexual mothers and the difficulties found in the management of synchronous meetings for data collection among these women, it was found that asynchronous methods of online research are potential strategies for this group in specific, considered of difficult access. This work aims to demonstrate the methodological path to develop exploratory research, with a qualitative approach, by online methods, applying strategies such as open-ended interviews and online focus groups, by using WhatsApp as social media.

Pela urgente e definitiva inclusão dos campos de identidade de gênero e orientação sexual nos sistemas de informação em saúde do SUS: o que podemos aprender com o surto de monkeypox? / A call for the urgent and definitive inclusion of gender identity and sexual orientation data in the Brazilian health information systems: what can we learn from the monkeypox outbreak?

Resumo Neste documento trazemos um posicionamento para a comunidade científica e a sociedade civil acerca do desafio imposto à vigilância e às ações em saúde no Brasil relacionadas à monkeypox. Apresentamos pontos e encaminhamentos que podem subsidiar os aprendizados e os avanços a partir do atual cenário.

Abstract In this document, we present to the scientific community a proposal on how to deal with the challenge imposed on surveillance and health actions in Brazil regarding monkeypox, including points and directions that have the potential to support learning and enable advances in the current scenario.

A call for the urgent and definitive inclusion of gender identity and sexual orientation data in the Brazilian health information systems: what can we learn from the monkeypox outbreak? / Pela urgente e definitiva inclusão dos campos de identidade de gênero e orientação sexual nos sistemas de informação em saúde do SUS: o que podemos aprender com o surto de monkeypox?

In this document, we present to the scientific community a proposal on how to deal with the challenge imposed on surveillance and health actions in Brazil regarding monkeypox, including points and directions that have the potential to support learning and enable advances in the current scenario.

Neste documento trazemos um posicionamento para a comunidade científica e a sociedade civil acerca do desafio imposto à vigilância e às ações em saúde no Brasil relacionadas à monkeypox. Apresentamos pontos e encaminhamentos que podem subsidiar os aprendizados e os avanços a partir do atual cenário.

Prevalence of unprotected sexual activity in the Brazilian population and associated factors: National Health Survey, 2019. / Prevalência de atividade sexual desprotegida na população brasileira e fatores associados: Pesquisa Nacional de Saúde, 2019.

OBJECTIVE: To estimate prevalence of unprotected sexual activity and associated factors in the Brazilian population. METHODS: This was a cross-sectional study with 61,523 adults aged 18 years or older who took part in the 2019 National Health Survey. We estimated prevalence of unprotected sexual activity in the last year. We analyzed association of socioeconomic and demographic variables with the outcome using Poisson regression, estimating prevalence ratios (PR) and 95% confidence intervals (95%CI). RESULTS: Prevalence of unprotected sexual activity was 76.9% (95%CI 76.3;77.6), being higher in all the country's regions in comparison to the Northern region, as well as being higher among people living in rural areas (PR = 1.04; 95%CI 1.03;1.06), females (PR = 1.06; 95%CI 1.05;1.08), participants aged 60 years or older (PR = 1.33; 95%CI 1.27;1.38), married individuals (PR = 1.25; 95%CI 1.23;1.27) and those with less education (PR = 1.05; 95%CI 1.03;1.06). CONCLUSION: Strategies aimed at groups with higher prevalence of unprotected sexual activity are necessary.

Desafios da saúde da população LGBTI+ no Brasil: uma análise do cenário por triangulação de métodos / Health challenges in the LGBTI+ population in Brazil: a scenario analysis through the triangulation of methods

Resumo Este artigo objetiva refletir sobre os desafios da saúde de pessoas lésbicas, gays, bissexuais, travestis, transexuais, intersexuais e outras minorias sexuais e de gênero (LGBTI+) no cenário brasileiro atual. Baseado no método de triangulação, incluiu análise de políticas, pesquisa qualitativa sobre percepções de atores-chave do Sistema Único de Saúde (SUS) - pessoas usuárias LGBTI+, profissionais e gestores(as) - a partir de dois projetos desenvolvidos no Sudeste e Sul do Brasil, analisados por equipe interdisciplinar de pesquisadores(as). Foram elencados os principais problemas enfrentados pela população LGBTI+, sinalizando alguns dos avanços necessários. Alguns desses desafios incluem: o acesso de LGBTI+ ao SUS; a necessidade de capacitação de profissionais; a interiorização e descentralização de serviços sensíveis à LGBTI+; as distintas formas de violências e discriminação; lacunas de pesquisas em saúde de segmentos específicos, como de lésbicas, bissexuais, intersexos e outras minorias sexuais. Os resultados corroboram a urgência da implementação plena da "Política Nacional de Saúde Integral de LGBT". O reconhecimento das demandas dessa população contribui para alcançar os princípios que norteiam o SUS.

Abstract This article aims to reflect on the current health challenges of lesbians, gays, bisexuals, transgenders, intersex, and other sexual and gender minorities (LGBTI+) within the Brazilian scenario. This study adopted a triangulation approach, based on two studies developed in the Southeast and South of Brazil, which included policy analysis and qualitative research on the perceptions of key actors from the Brazilian Unified Health System (SUS) - LGBTI+ users, workers, and managers. All data were analyzed by an interdisciplinary team of researchers. The main problems faced by the LGBTI+ population were registered, indicating some of the necessary progress. Some of these challenges include: access of the LGBTI+ population to SUS; the need to train health professionals; the decentralization of health services sensitive to the LGBTI+ population; the distinct forms of violence and discrimination; the lack of research in health care conducted with specific groups, such as lesbians, bisexuals, intersex, and other sexual minorities. The results reinforce the urgency for the complete implementation of the "National Policy for the Comprehensive Health of LGBT". The recognition of the LGBTI+ health needs will aid in achieving the principles which are the guiding principles of SUS.

Health challenges in the LGBTI+ population in Brazil: a scenario analysis through the triangulation of methods. / Desafios da saúde da população LGBTI+ no Brasil: uma análise do cenário por triangulação de métodos.

This article aims to reflect on the current health challenges of lesbians, gays, bisexuals, transgenders, intersex, and other sexual and gender minorities (LGBTI+) within the Brazilian scenario. This study adopted a triangulation approach, based on two studies developed in the Southeast and South of Brazil, which included policy analysis and qualitative research on the perceptions of key actors from the Brazilian Unified Health System (SUS) - LGBTI+ users, workers, and managers. All data were analyzed by an interdisciplinary team of researchers. The main problems faced by the LGBTI+ population were registered, indicating some of the necessary progress. Some of these challenges include: access of the LGBTI+ population to SUS; the need to train health professionals; the decentralization of health services sensitive to the LGBTI+ population; the distinct forms of violence and discrimination; the lack of research in health care conducted with specific groups, such as lesbians, bisexuals, intersex, and other sexual minorities. The results reinforce the urgency for the complete implementation of the "National Policy for the Comprehensive Health of LGBT". The recognition of the LGBTI+ health needs will aid in achieving the principles which are the guiding principles of SUS.

Este artigo objetiva refletir sobre os desafios da saúde de pessoas lésbicas, gays, bissexuais, travestis, transexuais, intersexuais e outras minorias sexuais e de gênero (LGBTI+) no cenário brasileiro atual. Baseado no método de triangulação, incluiu análise de políticas, pesquisa qualitativa sobre percepções de atores-chave do Sistema Único de Saúde (SUS) - pessoas usuárias LGBTI+, profissionais e gestores(as) - a partir de dois projetos desenvolvidos no Sudeste e Sul do Brasil, analisados por equipe interdisciplinar de pesquisadores(as). Foram elencados os principais problemas enfrentados pela população LGBTI+, sinalizando alguns dos avanços necessários. Alguns desses desafios incluem: o acesso de LGBTI+ ao SUS; a necessidade de capacitação de profissionais; a interiorização e descentralização de serviços sensíveis à LGBTI+; as distintas formas de violências e discriminação; lacunas de pesquisas em saúde de segmentos específicos, como de lésbicas, bissexuais, intersexos e outras minorias sexuais. Os resultados corroboram a urgência da implementação plena da "Política Nacional de Saúde Integral de LGBT". O reconhecimento das demandas dessa população contribui para alcançar os princípios que norteiam o SUS.

Prevalence of unprotected sexual activity in the Brazilian population and associated factors: National Health Survey, 2019 / Prevalencia de actividad sexual sin protección en la población brasileña y factores asociados: Encuesta Nacional de Salud, 2019 / Prevalência de atividade sexual desprotegida na população brasileira e fatores associados: Pesquisa Nacional de Saúde, 2019

Objective: To estimate the prevalence and factors associated with unprotected sexual activity in the Brazilian population. Methods: Cross-sectional study with 61.523 adults aged 18 years or older, participating in the 2019 National Health Survey. The prevalence of unprotected sexual activity in the last year was estimated. The association of socioeconomic and demographic variables with the outcome was analyzed using Poisson regression, with estimation of prevalence ratios (PR) and 95%CI. Results: The prevalence of unprotected sexual activity was 76.9% (95%CI 76.3;77.6), being higher in all regions compared to the North region, rural residents (PR=1.04 ­ 95%CI 1.03;1.06), female participants (PR=1.06 ­ 95%CI 1.05;1.08), participants aged 60 years or older (PR=1,33 ­ 95%CI 1,27;1,38), married (PR=1.25 ­ 95%CI 1.23;1.27), and less educated (PR=1.05 ­ 95%CI 1.03;1.06). Conclusion: Strategies aimed at groups with a higher prevalence of unprotected sexual activity are necessary.

Objetivo: Estimar la prevalencia y los factores asociados a la actividad sexual sin protección en la población brasileña. Métodos: Estudio transversal con 61.523 adultos mayores de 18 años participantes de la Encuesta Nacional de Salud 2019. Se estimó la prevalencia de actividad sexualsin protección en el último año. La asociación de variables socioeconómicas y demográficas con el desenlace se analizó mediante regresión de Poisson, con estimación de razones de prevalencia (RP) e IC95%. Resultados: La prevalencia de actividad sexual sin protección fue del 76,9% (IC95% 76,3; 77,6), siendo mayor en todas las regiones en comparación con el Norte, residentes rurales (RP=1,04 ­ IC95% 1,03;1,06), mujeres (RP=1,06 ­ IC95% 1,05;1,08), mayores de 60 años (RP=1,33 ­ IC95% 1,27;1,38), casados (RP=1,25 ­ IC95% 1,23;1,27) y menos educados (RP=1,05 ­ IC95% 1,03;1,06). Conclusión: Se necesitan estrategias dirigidas a los grupos con mayor prevalencia de actividad sexual sin protección.

Objetivo: Estimar a prevalência e fatores associados à atividade sexual desprotegida na população brasileira. Métodos: Estudo transversal com 61.523 adultos, na idade de 18 anos ou mais, participantes da Pesquisa Nacional de Saúde 2019. Foram estimadas as prevalências de atividade sexual desprotegida no último ano. A associação das variáveis socioeconômicas e demográficas com o desfecho foi analisada pela regressão de Poisson, com estimação das razões de prevalências (RPs) e intervalo de confiaça de 95% (IC95%). Resultados: A prevalência de atividade sexual desprotegida foi de 76,9% (IC95% 76,3;77,6), maior em todas as macrorregiões nacionais quando comparadas região Norte, em moradores da zona rural (RP=1,04 ­ IC95% 1,03;1,06), sexo feminino (RP=1,06 ­ IC95% 1,05;1,08), idade de 60 anos ou mais (RP=1,33 ­ IC95% 1,27;1,38), casados (RP=1,25 ­ IC95% 1,23;1,27) e menos escolarizados (RP=1,05 ­ IC95% 1,03;1,06). Conclusão: Estratégias direcionadas aos grupos com maior prevalência de atividade sexual desprotegida são necessárias.

The urgent and definitive inclusion of gender identity and sexual orientation data in the Brazilian Health Information systems: what can we learn from the monkeypox outbreak? / La inclusión urgente y definitiva de los datos de identidad de género y orientación sexual en los sistemas brasileños de información en salud: qué podemos aprender de la viruela del mono ¿brote? / Pela urgente e definitiva inclusão dos campos de identidade de gênero e orientação sexual nos sistemas de informação em saúde do SUS: o que podemos aprender com o surto de monkeypox?

In this document, we bring a position to the scientific community about the challenge imposed on surveillance and health actions in Brazil on monkeypox. We present points and directions that can support learning and advances from the current scenario.

En este documento, traemos una posición a la comunidad científica sobre el desafío impuesto a las acciones de vigilancia y salud en Brasil sobre la viruela símica. Presentamos puntos y direcciones que pueden apoyar aprendizajes y avances a partir del escenario actual.

Neste documento trazemos um posicionamento para a comunidade científica e sociedade civil acerca do desafio imposto à vigilância e as ações em saúde no Brasil sobre a monkeypox. Apresentamos pontos e encaminhamentos que podem subsidiar os aprendizados e os avanços a partir do atual cenário.

Study of Penis Structure and Development in Fetus With Prune Belly Syndrome.

OBJECTIVE: To evaluate the influence of prune belly syndrome (PBS) on the development of penises in human fetuses. METHODS: We studied 39 human fetuses (including 4 with PBS) aged 11-22 weeks post conception. We measured the length and width of the free portion and penis root and the penis total length (PTL). In 21 fetuses of the control group and in 3 with PBS we analyze the penile with histochemical and immunohistochemical methods. The total penile area, area of corpora cavernosa, area of corpus spongiosum, and thickness of tunica albuginea were measured by stereological method. Means were compared using the Kolmogorov-Smirnov and ANOVA test (P <.05). RESULTS: We did not observe difference in PTL (P = .999) when we compared the control group (4.69-29.77 mm, mean = 16.2 mm; SD = 6.34 mm) with the PBS (12.23-23 mm, mean = 16.16; SD = 4.99). The total penile area (P = .002), the area of corpora cavernosa (P = .023) and the area of corpus spongiosum (P = .004) had a significant increase when comparing the PBS with the control group. CONCLUSION: In fetuses with PBS there is no change in the length of the penis but we observed a low rate of growth in all the other histologic parameters analyzed, suggesting that PBS impacts the penile development.

Thermal imagery of woodland tree canopies provides new insights into drought-induced tree mortality.

Our understanding of how water dynamics determines the probability of tree mortality during drought is incomplete. Here we help address this shortcoming by coupling approaches from the disciplines of ecophysiology, geophysics and remote sensing in a woodland ecosystem undergoing protracted drying. Water uptake and use strategies varied between the dominant canopy species of the ecosystem. At one extreme were species that tightly regulate their water status, which is broadly consistent with the definition of isohydry. The higher leaf temperatures revealed by thermal imagery of these isohydric species are likely a reflection of reduced latent cooling owing to a stringent control of transpiration rate. Where silty sediments occur in the root zone, this strategy may have the effect of limiting the water sources available to these species during prolonged drought because of an insufficient hydraulic gradient for water uptake. In contrast were species that allowed their water status to fluctuate, operating in a fashion more consistent with anisohydry. For these species, latent cooling owing to relatively high transpiration rates maintained leaf temperatures near, or below, the ambient air temperature. The resulting drawdown in leaf water potential between soil and leaves in these anisohydric species may generate a sufficient hydraulic gradient to enable water uptake from silty soil during seasonal or prolonged droughts. In this way the spatial distribution of fine textured soil could indicate areas where the isohydric hydraulic control strategy is disadvantageous during prolonged droughts or where annual soil water recharge has fallen below a critical threshold.

Violência simbólica na experiência de estudantes universitários LGBT / Violencia simbólica en la experiencia de estudiantes universitarios LGBT / Symbolic violence in undergraduate LGBT students' experiences

Resumo Desde a infância, a violência simbólica é um processo vivenciado por pessoas LGBT diante das sanções da heteronormatividade hegemônica. A universidade se constitui como espaço de possibilidade e mudança para muitas pessoas, com uma expectativa em particular: a de maior abertura à pluralidade moral e, portanto, à diversidade. Este artigo investiga as experiências de violência simbólica e os contornos do habitus vividos por universitários LGBT, por meio de entrevistas não estruturadas com 16 estudantes analisadas a partir do arcabouço teórico de Bourdieu. A violência simbólica se mostrou presente na vida de todos, se manifestando em diversos ambientes e instituições, inclusive na vida acadêmica universitária, mas principalmente na vida familiar e escolar. Diante das imposições do habitus heterossexual, os indivíduos desenvolvem diversos recursos, com destaque para a aquisição de capital social, como a militância LGBT. No entanto, a universidade precisa concretizar ações específicas de enfrentamento às violências e de respeito à diversidade, considerando seu papel como instituição socialmente responsável pela educação de cidadãos para além de profissionais. Esse é um desafio já presente na definição da agenda ético-política universitária, que se torna ainda mais complexo em tempos de luta pela própria manutenção do sistema democrático no Estado brasileiro.

Resumen Desde la infancia, la violencia simbólica es un proceso vivido por las personas LGBT ante las sanciones de la heteronormatividad hegemónica. La universidad se constituye como espacio de posibilidad y cambio para muchos, con una expectativa en particular: la de mayor apertura a la pluralidad moral y, por lo tanto, a la diversidad. Han sido investigadas las experiencias de violencia simbólica y los contornos del habitus vividos por universitarios LGBT. Han sido realizadas entrevistas no estructuradas con 16 estudiantes, analizadas a partir del marco teórico de Bourdieu. La violencia simbólica se mostró presente en la vida de todos. Ocurre en diversos ambientes e instituciones, con primacía en la familia y en la escuela, pero también en la vida académica universitaria. Ante las imposiciones del habitus heterosexual, los individuos desarrollan recursos, entre los cuales hay que destacar la adquisición de capital social, como la militancia LGBT. Pero la universidad, como institución socialmente responsable por la educación de ciudadanos más allá de profesionales, necesita concretar acciones específicas de enfrentamiento a las violencias y de respeto a la diversidad. Un desafío ya presente en la definición de la agenda ético-política universitaria, aún más complejo en tiempos de lucha por el propio mantenimiento del sistema democrático en el Estado brasileño.

Abstract Since childhood, symbolic violence has been a process experienced by LGBT people facing the sanctions of hegemonic heteronormativity. University is a space of possibility and change for many people, with a particular expectation: of greater openness to moral plurality and, thus, diversity. This article investigates experiences of symbolic violence, and the contours of the habitus lived by LGBT university students, by using unstructured interviews with 16 students, analyzed from the theoretical framework of Bourdieu. Symbolic violence was present in all their lives, showing itself in different environments and institutions, including the university academic life, but mostly on their family and school life. Facing impositions of the heterosexual habitus, individuals develop resources, with the acquisition of social capital, such as LGBT militancy, standing out. However, the university needs to concretize specific actions to face violence and respect diversity, considering its role as an institution socially responsible for the education of citizens on top of professionals. This is a challenge already present in the definition of the ethical-political university agenda, that becomes even more complex in times of struggle for the very maintenance of the democratic system in the Brazilian State.

Prevalência de atividade sexual desprotegida na população brasileira e fatores associados: Pesquisa Nacional de Saúde, 2019 / Prevalencia de actividad sexual sin protección en la población brasileña y factores asociados: Encuesta Nacional de Salud, 2019 / Prevalence of unprotected sexual activity in the Brazilian population and associated factors: National Health Survey, 2019

Objetivo: Estimar a prevalência e fatores associados à atividade sexual desprotegida na população brasileira. Métodos: Estudo transversal com 61.523 adultos, na idade de 18 anos ou mais, participantes da Pesquisa Nacional de Saúde 2019. Foram estimadas as prevalências de atividade sexual desprotegida no último ano. A associação das variáveis socioeconômicas e demográficas com o desfecho foi analisada pela regressão de Poisson, com estimação das razões de prevalência (RPs) e intervalo de confiança de 95% (IC95%). Resultados: A prevalência de atividade sexual desprotegida foi de 76,9% (IC95% 76,3;77,6), maior em todas as macrorregiões nacionais quando comparadas à região Norte, em moradores da zona rural (RP = 1,04; IC95% 1,03;1,06), sexo feminino (RP = 1,06; IC95% 1,05;1,08), idade de 60 anos ou mais (RP = 1,33; IC95% 1,27;1,38), casados (RP = 1,25; IC95% 1,23;1,27) e menos escolarizados (RP = 1,05; IC95% 1,03;1,06). Conclusão: Estratégias direcionadas aos grupos com maior prevalência de atividade sexual desprotegida são necessárias.

Objetivo: Estimar la prevalencia y los factores asociados a la actividad sexual sin protección en la población brasileña. Métodos: Estudio transversal con 61.523 adultos mayores de 18 años participantes de la Encuesta Nacional de Salud 2019. Se estimó la prevalencia de actividad sexual sin protección en el último año. La asociación de variables socioeconómicas y demográficas con el desenlace se analizó mediante regresión de Poisson, con estimación de razones de prevalencia (RP) e IC95%. Resultados: La prevalencia de actividad sexual sin protección fue del 76,9% (IC95% 76,3;77,6), siendo mayor en todas las regiones en comparación con el Norte, residentes rurales (RP = 1,04; IC95% 1,03;1,06), sexo femenino (RP = 1,06; IC95% 1,05;1,08), mayores de 60 años (RP = 1,33; IC95% 1,27;1,38), casados (RP = 1,25; IC95% 1,23;1,27) y menos educados (RP = 1,05; IC95% 1,03;1,06). Conclusión: Se necesitan estrategias dirigidas a los grupos con mayor prevalencia de actividad sexual sin protección.

Objective: To estimate prevalence of unprotected sexual activity and associated factors in the Brazilian population. Methods: This was a cross-sectional study with 61,523 adults aged 18 years or older who took part in the 2019 National Health Survey. We estimated prevalence of unprotected sexual activity in the last year. We analyzed association of socioeconomic and demographic variables with the outcome using Poisson regression, estimating prevalence ratios (PR) and 95% confidence intervals (95%CI). Results: Prevalence of unprotected sexual activity was 76.9% (95%CI 76.3;77.6), being higher in all the country's regions in comparison to the Northern region, as well as being higher among people living in rural areas (PR = 1.04; 95%CI 1.03;1.06), females (PR = 1.06; 95%CI 1.05;1.08), participants aged 60 years or older (PR = 1.33; 95%CI 1.27;1.38), married individuals (PR = 1.25; 95%CI 1.23;1.27) and those with less education (PR = 1.05; 95%CI 1.03;1.06). Conclusion: Strategies aimed at groups with higher prevalence of unprotected sexual activity are necessary.