Stromal myofibroblasts in squamous cell carcinoma of the tongue in young patients - a multicenter collaborative study.

OBJECTIVE: The purpose of this study was to evaluate the presence of myofibroblasts, frequently associated with a more aggressive neoplastic behavior, in oral tongue squamous cell carcinoma (TSCC) of young patients and to compare with the distribution observed in older patients. STUDY DESIGN: Tumor samples from 29 patients younger than 40 years old affected by TSCC were retrieved and investigated for the presence of stromal myofibroblasts by immunohistochemical reactions against α smooth muscle actin, and the results obtained were compared to TSCC cases affecting older patients. RESULTS: No positive reaction could be found in the stromal areas devoid of neoplastic tissue, whereas myofibroblasts were present in 58.6% of the lesions in young patients and in 75.9% of the older ones. No significant difference was found when comparing the invasive front and the overall stroma of both groups, and no correlation could be obtained with stromal α smooth muscle actin expression, higher tumor grades or clinical stage (P > .05). CONCLUSION: There was no significant difference between the presence of stromal myofibroblasts of TSCC affecting young and old individuals.

Estudio histológico comparativo de la reparación ósea entre hueso alveolar y extra-alveolar en los cerdos sometidos a osteotomía con alta y baja velocidad, con refrigeración líquida / Comparative study of bone repair between alveolar and extra-alveolar bone in pigs subjected to osteotomy at low speed and high speed with liquid refrigeration

Introducción. Teniendo en cuenta que el proceso de reparación ósea en los cerdos se muestra en una mayor proximidad entre las variables histológicas estudiadas en comparación con otros modelos biológicos, el presente estudio tenía como objetivo evaluar el proceso histológico de la reparación ósea de osteotomías realizadas en huesos alveolares y extra-alveolar, utilizando instrumentos rotatorios con refrigeración líquida. Material y método. Dieciocho cerdos Large White con peso comprendido entre 20 y 25Kg fueron divididos en tres grupos de seis animales cada uno, con cada grupo formado por tres animales para evaluar la reparación de osteotomías con baja y alta velocidades en el hueso alveolar y tres en área extra-alveolar en los períodos de estudio de 7, 14 y 28 días. Resultados. Se observó que en el hueso alveolar en los tiempos post-operatorio de 14 y 28 días, los mejores resultados de reparación fueron en las osteotomías realizadas con baja velocidad, mientras que en el período post-operatorio de siete días, los resultados con alta velocidad fueron ligeramente mejores tanto en áreas alveolares como extra-alveolares. Para la metodología utilizada, no se encontraron diferencias estadísticamente significativas en el proceso de reparación ósea alveolar y extra-alveolar. Conclusiones. El proceso de reparación, por medio de análisis microscópico en la región alveolar y extra-alveolar, son similares con mejores resultados observados en osteotomías hechas con taladros en baja velocidad en los tiempos de catorce y veintiocho días y en el post-operatorio de siete días, los resultados con taladros de alta velocidad y la refrigeración fueron ligeramente mejores. Los trabajos de investigación utilizando cerdos como modelo animal son perfectamente viables(AU)

Introduction. Taking into account the bone repair process in pigs has shown a greater similarity among the histological variables studied compared to other biological models, the present study has as its aim to evaluate the histological bone repair process of osteotomy performed on alveolar and extra-alveolar bones, using drilling tools with liquid refrigeration. Material and method. Eighteen Large White pigs weighing between 20 and 25 Kg were divided into three groups of six animals in order to evaluate the osteotomy repairs with low and high speed in the alveolar bone and threes in the extra-alveolar area, study periods of 7, 14 and 28 days. Results. It was observed that in the alveolar bone at the postoperative times of 14 and 28 days, the best repair results were in the osteotomy performed with low speed, while in the 7 day postoperative period, the results with high speed were slightly better, in alveolar areas as well as extra-alveolar areas. There no statistically significant differences between the alveolar and extra-alveolar bone repair process. Conclusions. The repair process, by means of microscopic analysis in the alveolar and extra-alveolar areas, are similar with better results observed in osteotomies performed with low speed drills in the 14 and 28 day study periods, and at 7 days postoperative the results with high speed drills and refrigeration were slightly better. Research works using pigs as an animal model are perfectly viable(AU)

Angioleiomyoma affecting the lips: Report of 3 casesand review of the literature

Angioleiomyoma is an uncommon benign soft tissue tumor usually found in the lower extremities and rarelyobserved in oral tissues. It is microscopically characterized as a proliferation of smooth muscle cells intermingledwith abundant vascular channels. Oral angioleiomyomas affect mostly the lips, palate, buccal mucosa andtongue, and appears as a submucosal painless nodule. Upper lip is seldom affected and only few cases have beenreported. We report three additional cases of angioleiomyoma affecting the lips of elderly patients. All lesionswere asymptomatic and presented as submucosal nodules of approximately 1cm. Microscopic analysis on H&Esections revealed similar pattern in all cases, showing well-circumscribed and encapsulated tumors characterizedby proliferation of smooth muscle cells and large amount of wide vascular spaces of varying sizes. Most tumorcells were immunoreactive for α-smooth muscle actin, desmin and HHF-35. CD34 was also positive on the endothelialcells. All patients were surgically treated and no recurrence was observed so far. The oral pathologistsand clinicians should consider this entity when assessing nodular lesions on upper lip (AU)

Angioleiomyoma affecting the lips: report of 3 cases and review of the literature.

Angioleiomyoma is an uncommon benign soft tissue tumor usually found in the lower extremities and rarely observed in oral tissues. It is microscopically characterized as a proliferation of smooth muscle cells intermingled with abundant vascular channels. Oral angioleiomyomas affect mostly the lips, palate, buccal mucosa and tongue, and appears as a submucosal painless nodule. Upper lip is seldom affected and only few cases have been reported. We report three additional cases of angioleiomyoma affecting the lips of elderly patients. All lesions were asymptomatic and presented as submucosal nodules of approximately 1cm. Microscopic analysis on H&E sections revealed similar pattern in all cases, showing well-circumscribed and encapsulated tumors characterized by proliferation of smooth muscle cells and large amount of wide vascular spaces of varying sizes. Most tumor cells were immunoreactive for a-smooth muscle actin, desmin and HHF-35. CD34 was also positive on the endothelial cells. All patients were surgically treated and no recurrence was observed so far. The oral pathologists and clinicians should consider this entity when assessing nodular lesions on upper lip.

Atypical dento-alveolar fracture fixed with screws: a technical note.

Dento-alveolar process fracture is an important and common event in the dental office practice usually managed under the well-established protocols, but sometimes this kind of lesion is evaluated in the hospital emergency rooms without attention to the dental injuries. In this type of trauma, the time between the injury and the definitive resolution is essential for the treatment success, usually 1 h in cases of dento-alveolar fractures (tooth and alveolar bone). This paper describes the management of a patient with unusual dento-alveolar fracture caused by gunshot and treated using screw fixation.

Pénfigo vulgar importancia para el odontólogo en el diagnóstico / Pemphigus vulgaris importance of the dentist in its diagnosis

El pénfigo vulgar es una enfermedad vesiculo ampollar crónica y grave que compromete piel y mucosas. La presencia de anticuerpos antidesmosómicos resulta en la disolución de la sustancia cementante intercelular para la destrucción de los desmosomas que mantienen unidas a las células epiteliales generando una separación intraepitelial característica que ocurre luego arriba de la camada de células basales. El pénfigo vulgar es una condición de revelancia odontológica que si no estratada puede resultar en la muerte del paciente. El compromiso de la cavidad bucal en la mayoria de los casos aliado a la importancia del diagnóstico precoz para el pronóstico y tratamiento, refuerzan la necesidad del conocimiento de esa condición por el odontólogo

Pemphigus vulgaris is a chronic and serious auto-imune vesiculo-bullous disease that affects skin and mucous membrane. Antidesmosomal antibodies dissolve intercellular substance that keeps epithelial cells together, resulting in an intraepithelial blister just above basal epithelial layer. Without treatment, pemphigus vulgaris leads patient to die. The fact that this disorder presents oral manifestation in most cases, in addiction to the relevance of a precocious diagnosis to the success of the treatment and prognosis support the importance of about the knowledge of this disease to dentist's notice

O pênfigo vulgar é uma doença auto-imune, vesículo-bolhosa, crônica e grave, que acomete pele e mucosas. A presença de anticorpos antidesmossômicos resulta na dissolução da substância cimentante intercelular pela destruição dos desmossomos que mantêm unidas as células epiteliais gerando uma separação intra-epitelial característica, que ocorre logo acima da camada de células basais. O pênfigo vulgar é uma condição de relevância odontológica que, se não tratada, pode resultar no óbito do paciente. O acometimento da cavidade bucal na maioria dos casos aliado à importância do diagnóstico precoce para o prognóstico e tratamento reforçam a necessidade do conhecimento dessa condição pelo cirurgiãodentista

Cisto nasolabial: revisão de literatura e relato de um caso clínico / Nasolabial cyst: review of literature and a case report

O cisto nasolabial referido também como nasoalveolar ou de Klestadt é raro e bem reconhecido. Faz parte do grupo dos cistos epiteliais de desenvolvimento, não odontogênicos. Origina-se da proliferação dos restos epiteliais localizados na junção dos processos globular, nasal lateral e maxilar. Sugere-se, ainda, uma possível origem a partir do ducto nasolacrimal. Situa-se junto à asa do nariz, superficialmente ao tecido ósseo. É objetivo desse trabalho relatar um caso desta patologia, abordando aspectos clínicos, histopatológicos e radiográficos, contribuindo para o enriquecimento da literatura e, neste sentido, alertar o profissional quanto à sua responsabilidade no diagnóstico