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2.
Curr Oncol ; 16(1): 62-6, 2009 Jan.
Article in English | MEDLINE | ID: mdl-19229374

ABSTRACT

Brain metastasis is increasingly common, affecting 20%-40% of cancer patients. After diagnosis, survival is usually limited to months in these patients. Treatment for brain metastasis includes whole-brain radiation therapy, surgical resection, or both. These treatments aim to slow progression of disease and to improve or maintain neurologic function and quality of life.Although less common, primary brain tumours produce symptoms that are similar to those of brain metastasis. Glioblastoma, the most common malignant tumour of the brain, has a median survival of less than 12 months. Patients are often treated with surgical resection followed by radical radiation therapy and chemotherapy.Here, we present 2 separate cases of lesions in the brain radiologically compatible with brain metastasis. In both cases, no primary cancer site had been established, and neurosurgical intervention was sought to obtain a pathologic diagnosis. Both cases were pathologically confirmed as glioblastoma. These cases demonstrate the importance of differentiation between brain metastases and primary brain tumours to ensure that the appropriate management strategy is implemented.

3.
Can J Neurol Sci ; 34(2): 181-6, 2007 May.
Article in English | MEDLINE | ID: mdl-17598595

ABSTRACT

OBJECTIVE: There has been a paucity of information on the epidemiology of primary brain tumors (BTs) in Canada. This study documents epidemiology of primary BTs in Saskatchewan over three decades to define their current state, changing pattern over years and relative distribution in two geographically defined areas of the province. METHODS: Data on all primary BTs from 1970 to 2001 from the Brain Tumor Registry in Saskatchewan was collected. The aggregate data on primary BTs including the time-series for incidence, age, geographic location and sex were statistically analyzed using SPSS 13. Poisson regression was used to model the incidence as a function of decade of diagnosis and age at the time of diagnosis. RESULTS: The average annual incidence of primary BTs was 11.1 per 100,000 person-years (male 12.5 per 100.000 and female 9.8 per 100.000). Males constituted 54.5% of all these tumors. The age distribution of tumors was bimodal with peaks at 5 years and 65 years. During this time, the incidence of primary BTs has increase predominantly in non-malignant types. No difference was found in the rate of all the diagnosed primary BTs combined, meningioma and lymphoma between the northern part (Regina) and southern part (Saskatoon) of the province. CONCLUSIONS: The incidence of BTs in Saskatchewan is more than previously reported in Canada. There is a temporal trend in increasing incidence of some of the BTs predominantly in the non-malignant types. No spatial difference in the incidence of primary BTs was shown in this province. These data will provide useful information to guide the future studies on BTs changing patterns, possible etiologies and efficient resource allocation for management of these diseases.


Subject(s)
Brain Neoplasms/epidemiology , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Brain Neoplasms/classification , Child , Child, Preschool , Female , Humans , Incidence , Infant , Male , Middle Aged , Registries , Retrospective Studies , Saskatchewan/epidemiology , Sex Distribution
4.
Neurosurgery ; 48(6): 1246-53; discussion 1253-4, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11383726

ABSTRACT

OBJECTIVE: Hydrocephalus (HCP) resulting from cerebellopontine angle (CPA) tumors is not rare. This retrospective study was designed to investigate the incidence of HCP and the clinical presentations, management options, and outcomes of HCP in 284 patients with CPA tumors. METHODS: A retrospective study of 284 consecutive patients with CPA tumors (mostly vestibular schwannomas) treated from 1985 to 1996 at Toronto Western Hospital managed by one surgical team consisting of a neurosurgeon and a neuro-otologist. RESULTS: Thirty-nine patients (13.7%) had radiographic and/or clinical evidence of HCP, 37 preoperatively and 2 postoperatively. Tumor type distribution was 33 vestibular schwannomas, 5 meningiomas, and 1 cavernous hemangioma. Only five patients (12%) had obvious obstruction at the fourth ventricular level. In 36 patients (92%), symptoms were mostly chronic and mild, consistent with normal pressure hydrocephalus. Multivariate analysis confirmed the strong association of tumor size and incidence of HCP (P < .0001). Four patients underwent permanent shunting before microsurgical tumor excision, mainly because of florid symptoms of HCP. Microsurgical tumor excision without preoperative shunting was performed in 23 patients, 5 of whom required postoperative shunting in the first 2 months after tumor excision. Eighteen patients (78%) did not need shunts after tumor resection. With regard to tumor size, the postoperatively shunted group did not differ from the patients who had surgery but did not require shunt treatment (P < 0.50). The remaining 10 patients with preoperative HCP received shunts as the only treatment (3 patients), stereotactic radiosurgery (3 patients), or expectant management (4 patients). Two other patients without preoperative HCP developed postoperative HCP and required shunts. Postoperatively, we observed a significant (P < 0.001) increase in the incidence of pseudomeningocele and a nonsignificant (P < 0.1) increase in cerebrospinal fluid leaks (rhinorrhea and/or otorrhea) in patients without shunts as compared with postoperative patients without HCP. The patients were followed after any treatment for a mean of 3.2 years (range, 6 mo-10 yr). Follow-up in the patients who had surgery but did not require a shunt revealed a 61% decrease in clinical symptoms related to HCP and a 75% decrease in radiographic signs of HCP. CONCLUSION: In the presence of HCP, operative resection of CPA tumors can be performed without permanent cerebrospinal fluid shunting. Precautionary measures to decrease the incidence of postoperative complications related to cerebrospinal fluid leak in patients with preoperative HCP include meticulous obliteration of any exposed air cells, including those around the internal auditory canal, accurate restoration of the dural barrier, and temporary lowering of intracranial pressure with a ventricular or lumbar drain. Patients with persistent symptomatic HCP after tumor excision should be treated with a ventriculoperitoneal shunt. Delaying this decision until the postoperative period is safe and avoids unnecessary shunting in the majority of patients.


Subject(s)
Brain Neoplasms/complications , Hydrocephalus/etiology , Hydrocephalus/surgery , Neuroma, Acoustic/complications , Cerebellopontine Angle , Cohort Studies , Hemangioma, Cavernous/complications , Humans , Meningeal Neoplasms/complications , Meningioma/complications , Neurosurgical Procedures/adverse effects , Postoperative Complications/prevention & control , Retrospective Studies , Ventriculoperitoneal Shunt
5.
Can J Neurol Sci ; 28(2): 155-8, 2001 May.
Article in English | MEDLINE | ID: mdl-11383942

ABSTRACT

BACKGROUND: Traumatic retroperitoneal hematoma in the iliacus muscle is an unusual but potentially serious cause of femoral compression neuropathy. CASE REPORT: We describe the clinical, imaging, and management features of a case of traumatic iliacus retroperitoneal hematoma with delayed manifestation of femoral neuropathy. DISCUSSION: The anatomical substrate for hematoma formation with subacute compression of the femoral nerve is emphasized. A subacute compartment syndrome with progressive edema, swelling and ischemia of iliacus compartment is suggested as the underlying cause. Early fasciotomy with or without hematoma evacuation should be considered in order to provide rapid decompression and to minimize the chance of permanent nerve injury.


Subject(s)
Femoral Nerve , Hematoma/complications , Nerve Compression Syndromes/etiology , Adolescent , Athletic Injuries/complications , Athletic Injuries/diagnostic imaging , Hematoma/diagnostic imaging , Humans , Ilium , Male , Nerve Compression Syndromes/diagnostic imaging , Retroperitoneal Space , Tomography, X-Ray Computed
6.
Neurosurgery ; 48(2): 444-5; discussion 445-6, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11220393

ABSTRACT

OBJECTIVE: Facet dislocations commonly require intraoperative reduction after closed reduction with traction has failed. Reduction should be performed in a gradual, controlled fashion to prevent additional inadvertent spinal cord compromise. METHODS: We describe a new technique for safe and simple dorsal reduction of facet dislocations by use of a modified interlaminar spreader. This technique requires only minimal controlled manipulation of the spine. RESULTS: We have used this technique in 52 consecutive patients with no complications or failures related to its use in open reduction. This technique increases the stability of the cervical spine after reduction because it limits bone removal from the facet joints. CONCLUSION: This technique provides a feasible and reliable approach to open reduction of cervical facet dislocations via the posterior approach.


Subject(s)
Cervical Vertebrae/surgery , Joint Dislocations/surgery , Neurosurgical Procedures/instrumentation , Spine/surgery , Equipment Design , Humans
7.
J Neurosurg ; 87(4): 633-5, 1997 Oct.
Article in English | MEDLINE | ID: mdl-9322854

ABSTRACT

A spinal epidural arteriovenous fistula with secondary reflux into the perimedullary veins is a rare entity. The authors present such a case with a discussion of its pathophysiology and treatment. The mechanism for formation of a spinal dural arteriovenous fistula is outlined based on the anatomical substrates in this region.


Subject(s)
Arteriovenous Fistula/etiology , Dura Mater/blood supply , Spinal Cord/blood supply , Aged , Arteries , Arteriovenous Fistula/physiopathology , Arteriovenous Fistula/surgery , Humans , Ligation , Male , Regional Blood Flow , Sacrum/blood supply , Veins/physiopathology
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