ABSTRACT
Z,E-isomerization has been investigated for the series of the N-arylthio-1,4-benzoquinonimines using a line shape analysis in the (1)H NMR spectra. Thermodynamic parameters and substituent effects have been analyzed for the isomerization process. It has been shown based on the DFT (B3LYP) calculations that the dynamic transformation for N-arylthio-1,4-benzoquinonimines should be considered as a combination of the two different processes, a rotation about the N-S bond and an inversion at nitrogen via the transition state with the linear C=N-S moiety. The free energies of activation for the isomerization (DeltaG(298 K)) measured experimentally depend on the substitution in the quinonimine moiety and phenyl ring and can be referred either to the inversion of the nitrogen atom or to the hindered rotation about the N-S bond.
Subject(s)
Benzoquinones/chemistry , Imines/chemistry , Magnetic Resonance Spectroscopy/methods , Models, Chemical , Sulfhydryl Compounds/chemistry , Molecular Structure , Quantum Theory , Stereoisomerism , ThermodynamicsABSTRACT
The forty-years experience of treatment of 125 patients with thymic gland tumors was summarized, in 113 of them thymoma was revealed. In the disease of I-II stages the five-year survival index had constituted 75.6%, and in III-IV stages the method of choice is combined treatment, after which the five-years survival index does not exceed 31.2%. It is necessary to perform additional studying of factors, influencing the result of treatment of the thymic gland tumor.
Subject(s)
Lipoma/surgery , Teratoma/surgery , Thymectomy/methods , Thymoma/surgery , Thymus Neoplasms/surgery , Adolescent , Adult , Aged , Child , Combined Modality Therapy , Female , Humans , Lipoma/drug therapy , Lipoma/radiotherapy , Male , Middle Aged , Teratoma/drug therapy , Teratoma/radiotherapy , Thymoma/drug therapy , Thymoma/radiotherapy , Thymus Neoplasms/drug therapy , Thymus Neoplasms/radiotherapyABSTRACT
The results of treatment of 256 patients with complicated closed chest injury are discussed. Multiple fractures of the ribs were found in 178, closed pneumothorax in 127, pneumohemothorax in 71, isolated hemothorax in 55, and rupture of the diaphragm in 3 patients. Most patients received nonoperative treatment, 5 patients (6.1%) needed emergency thoracotomy. Early drainage of the pleural cavity, endoscopic (thoracoscopy, bronchoscopy) methods of treatment, mechanical stabilization of floating rib fractures made it possible to improve the results and reduce the terms of treatment. Two (0.8%) persons died from shock and cardiopulmonary insufficiency.