ABSTRACT
Regulation of lipid peroxidation is realized not only by antioxidant enzymes but by natural antioxidants as well. We have lately succeeded, together with the students, in identifying antioxidant properties of quaternary ammonium compounds, which fact makes it possible for the above properties to gain extensive applicability in a setting where there is this variety of disbolism. One of such drug preparations is ethonium. The article contains information about uses of ethonium in the tablet dose form. The tablets are of little toxicity, they stimulate the oxidation-reduction processes and proved to be effective in experimental gastric and duodenal ulcers.
Subject(s)
Anti-Ulcer Agents/pharmacology , Antioxidants/pharmacology , Lipid Peroxidation/drug effects , Quaternary Ammonium Compounds/pharmacology , Adult , Aged , Aged, 80 and over , Anti-Ulcer Agents/administration & dosage , Antioxidants/administration & dosage , Chronic Disease , Drug Evaluation , Duodenal Ulcer/drug therapy , Duodenal Ulcer/enzymology , Female , Gastric Mucosa/drug effects , Gastric Mucosa/enzymology , Humans , Male , Middle Aged , Quaternary Ammonium Compounds/administration & dosage , Stomach Ulcer/drug therapy , Stomach Ulcer/enzymology , TabletsABSTRACT
Experiments on albino rats were made to reveal antioxidant activity of bisquaternary ammonium compounds of the methylene series (ethonium, thionium and dodeconium). It is determined by the enhancement of superoxide anion radicals neutralization and splitting of lipoperoxides.
Subject(s)
Antioxidants/pharmacology , Hexamethonium Compounds/pharmacology , Animals , Dose-Response Relationship, Drug , Lipid Peroxidation/drug effects , Liver/drug effects , Liver/metabolism , Male , Rats , Superoxide Dismutase/drug effects , Superoxide Dismutase/metabolismABSTRACT
The paper deals with the experimental study of antistaphylococcal properties of thionium--a derivative of bis-quarternary ammonium compounds. High bactericide activity of the preparation is revealed as a result; it is preserved under high contents of protein substances in the media. The sensitivity of staphylococcal strains to thionium is not affected by the initial sensitivity of microorganisms to antibiotics. The preparations interaction with benzylpenicillin and gentamycin has been studied. Synergist effect of sub-bacteriostatic doses of thionium with the mentioned antibiotics has been found. Effect of benzylpenicillin increases 4-32 times, that of gentamycin--64-512 times independent of the primary sensitivity to these antibiotics. The further study of a new antistaphylococcal preparation is advisable.
Subject(s)
Anti-Bacterial Agents/pharmacology , Quaternary Ammonium Compounds/pharmacology , Staphylococcus aureus/drug effects , Dose-Response Relationship, Drug , Humans , Microbial Sensitivity Tests , Staphylococcus aureus/isolation & purificationSubject(s)
Benzyl Compounds/standards , Toluene/analogs & derivatives , Water Pollutants, Chemical/analysis , Water Pollutants/analysis , Water Supply/standards , Animals , Benzyl Compounds/administration & dosage , Benzyl Compounds/analysis , Benzyl Compounds/toxicity , Dose-Response Relationship, Drug , Female , Fetal Death/chemically induced , Male , Maximum Allowable Concentration , Mice , Rats , Sperm Immobilizing Agents , Sperm Motility/drug effects , Sperm Motility/physiology , Toluene/analysis , Toluene/toxicity , Ukraine , Water Pollutants, Chemical/toxicity , Water Supply/analysisSubject(s)
Escherichia coli/drug effects , Quaternary Ammonium Compounds/pharmacology , Anti-Bacterial Agents/pharmacology , Cell Membrane/drug effects , Cell Membrane/enzymology , Cell Membrane Permeability/drug effects , Dose-Response Relationship, Drug , Escherichia coli/enzymology , Oxidoreductases/metabolismSubject(s)
Pyrimidines/toxicity , Water Pollutants, Chemical/toxicity , Water Pollutants/toxicity , Animals , Female , Humans , Male , Maximum Allowable Concentration , Mice , RatsSubject(s)
Anti-Infective Agents/pharmacology , Bis-Trimethylammonium Compounds/pharmacology , Quaternary Ammonium Compounds/pharmacology , Surface-Active Agents/pharmacology , Animals , Anti-Bacterial Agents , Anti-Infective Agents/toxicity , Bacteria/drug effects , Bis-Trimethylammonium Compounds/toxicity , Candida albicans/drug effects , Guinea Pigs , Lethal Dose 50 , Mice , Microbial Sensitivity Tests , Quaternary Ammonium Compounds/toxicity , Surface-Active Agents/toxicitySubject(s)
Methionine/toxicity , Vitamins/toxicity , Animals , Dogs , Drug Combinations/toxicity , MaleSubject(s)
Aniline Compounds/toxicity , Water Pollutants, Chemical/toxicity , Water Pollutants/toxicity , Water Supply , Aniline Compounds/analysis , Animals , Female , Fetal Death/chemically induced , Hematopoiesis/drug effects , Male , Maximum Allowable Concentration , Mice , Organ Size/drug effects , Pregnancy , Rats , Time FactorsSubject(s)
Anti-Bacterial Agents/therapeutic use , Surface-Active Agents/therapeutic use , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Bacterial Infections/drug therapy , Drug Interactions , Drug Resistance, Microbial , Drug Synergism , Drug Therapy, Combination , Humans , Surface-Active Agents/pharmacologyABSTRACT
The combined effect of ethonium and 5 antibiotics belonging to different groups was studied with 30 clinical strains of P. aeruginosa. A 2--8-fold increase in the activity of kanamycin and tetracycline against some strains was observed. The MIC of carbenicillin, polymycin M and cefotaxime was lowered by 2--6 times and with respect to some strains by 16--32 times. The detergent is recommended to be used in combination with some antibiotics in treatment of infections caused by resistant strains of P. aeruginosa.
