Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
Add more filters










Database
Language
Publication year range
5.
Probl Endokrinol (Mosk) ; 29(1): 11-5, 1983.
Article in Russian | MEDLINE | ID: mdl-6835951

ABSTRACT

The blood and urine porphyrin content and porphyrin biosynthesis in the red blood cells after delta-amino levulinic acid (ALA) incubation, porphobilinogen and non-consumed ALA levels, porphobilinogen-synthetase activity were studied in 86 patients divided into 3 groups depending on diabetes severity. Porphyrin separation was investigated by means of thin-layer chromatography. It was found that porphyrin biosynthesis decreases in all diabetics at the early periods of the disease, not depending on its severity. Porphyrin biosynthesis is lowered during a phase of chronic renal insufficiency in patients with diabetic nephropathy. Porphyrin metabolic disorder is caused by hepatic dysfunction and diabetic nephropathy development.


Subject(s)
Diabetes Mellitus/metabolism , Porphyrins/biosynthesis , Adult , Aged , Diabetes Mellitus/pathology , Diabetic Nephropathies/metabolism , Diabetic Nephropathies/pathology , Female , Humans , Male , Middle Aged , Mitochondria, Liver/metabolism , Porphobilinogen Synthase/metabolism , Pyelonephritis/metabolism , Pyelonephritis/pathology
SELECTION OF CITATIONS
SEARCH DETAIL
...