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1.
J Am Vet Med Assoc ; 260(3): 326-334, 2021 11 18.
Article in English | MEDLINE | ID: mdl-34793328

ABSTRACT

OBJECTIVE: To determine survival time and quality of life of dogs that developed postattenuation neurologic signs (PANS) after surgical treatment of a single congenital portosystemic shunt and survived at least 30 days and identify whether neurologic signs present at the time of discharge would resolve or reoccur. ANIMALS: 50 client-owned dogs. PROCEDURES: Medical records were retrospectively reviewed, and follow-up data relating to neurologic signs and seizure activity were obtained. Owners were asked to complete a questionnaire related to the presence of neurologic signs, including seizures, and their dog's quality of life. RESULTS: Thirty of the 50 (60%) dogs had postattenuation seizures with or without other nonseizure neurologic signs, and 20 (40%) had neurologic signs other than seizures. Neurologic signs had fully resolved by the time of discharge in 24 (48%) dogs. Signs resolved in 18 of the remaining 26 (69%) dogs that still had PANS other than seizures at the time of discharge. Seizures reoccurred in 15 of the 30 dogs that had postattenuation seizures. Twenty-seven of 33 (82%) owners graded their dog's long-term (> 30 days after surgery) quality-of-life as high. Forty-five (90%) dogs survived > 6 months. Most (29/43 [67%]) neurologic signs (other than seizures) present at the time of hospital discharge resolved. CLINICAL RELEVANCE: Findings highlighted that survival times of > 6 months and a high QOL can be achieved in most dogs with PANS that survive at least 30 days. Most neurologic signs other than seizures resolved within 1 month postoperatively. Half of the dogs with postattenuation seizures had a reoccurrence.


Subject(s)
Dog Diseases , Portasystemic Shunt, Transjugular Intrahepatic , Animals , Dog Diseases/congenital , Dog Diseases/surgery , Dogs , Portal System/abnormalities , Portal System/surgery , Portasystemic Shunt, Transjugular Intrahepatic/veterinary , Postoperative Complications/veterinary , Quality of Life , Retrospective Studies , Treatment Outcome
2.
J Comp Pathol ; 184: 95-100, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33894885

ABSTRACT

Cutaneous and renal glomerular vasculopathy (CRGV) is an emerging disease in the UK, but its aetiology remains unclear. It is considered a thrombotic microangiopathy (TMA) in which the kidney and skin are the most commonly affected organs. We now document two cases of CRGV with brain lesions, which may have accounted for neurological signs displayed by these animals. The histopathological brain lesions were similar to TMA lesions in humans with thrombotic thrombocytopaenic purpura (TTP) and complement-mediated haemolytic uraemic syndrome (CM-HUS), in which the neurological signs are more associated with TMA than with any systemic disease or electrolyte imbalance. Fibrinoid necrosis in brain arterioles and associated lesions in these dogs were similar to those in human CM-HUS, indicating that the alternative complement pathway may play an important role in the pathophysiology of CRGV.


Subject(s)
Cerebral Small Vessel Diseases , Dog Diseases , Kidney Diseases , Skin Diseases/veterinary , Thrombotic Microangiopathies , Animals , Cerebral Small Vessel Diseases/veterinary , Dogs , Kidney , Kidney Diseases/veterinary , Kidney Glomerulus , Thrombotic Microangiopathies/veterinary
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