ABSTRACT
Magnetic particles are currently applied to special biomedical and environmental applications owing to their unique magnetic, morphological and substance-carrying capabilities. Very recently we introduced Magnetically Assisted Hemodialysis (MAHD), an innovative therapeutic application of Ferromagnetic Nanoparticles (FNs) for the treatment of End-Stage Renal Disease (ESRD). MAHD can be employed for the selective and efficient removal of toxins that, although of high biological importance, they cannot be handled by current Hemodialysis strategies. This work is focused on evaluating the biocompatibility of Fe3O4 FNs with cells of donated human blood, namely red blood cells (RBCs), white blood cells (WBCs) and platelets (Plts). To that end, optical microscopy and atomic force microscopy were employed for the morphological examination of blood cells that were maturated under the presence of Fe3O4 FNs by means of mild incubation up to 120 min at T=20 degrees C. As a conclusion we have not detected noticeable interference between RBCs, WBCs and Pits with FNs for the maturation conditions and the extreme FNs concentrations examined in this work.
Subject(s)
Biocompatible Materials/chemistry , Blood Cells , Ferrosoferric Oxide/chemistry , Magnetite Nanoparticles/chemistry , Biocompatible Materials/toxicity , Blood Cells/cytology , Blood Cells/drug effects , Ferrosoferric Oxide/therapeutic use , Ferrosoferric Oxide/toxicity , Humans , In Vitro Techniques , Kidney Failure, Chronic/therapy , Magnetite Nanoparticles/therapeutic use , Magnetite Nanoparticles/toxicity , Magnetite Nanoparticles/ultrastructure , Materials Testing , Microscopy, Atomic Force , Nanotechnology , Renal Dialysis/methodsABSTRACT
Charge ordering phenomena in overdoped La1-xCaxMnO3 (LCMO) manganites with x>or=0.5 are generally believed to be associated with the formation of charge stripes composed of alternating Mn3+ and Mn4+ charges. However, a number of recent experiments indicate that instead of stripes the charge in these systems is spatially organized in a uniform charge density wave. At the same time theory predicts that the ground state is modulated by an incommensurate (IC) orbital and charge soliton lattice. Here, by using nuclear magnetic resonance we provide the first direct evidence that the spin ground state in overdoped LCMO manganites is IC modulated with phase solitons. At higher temperatures the solitonic superstructure is replaced by a uniform spin-density wave, subjected to coherent slow fluctuations, showing a striking similarity with slow fluctuations in the striped phase of high T{c} cuprates and nickelates.
ABSTRACT
Magnetically assisted hemodialysis is a development of conventional hemodialysis and is based on the circulation of ferromagnetic nanoparticle-targeted binding substance conjugates (FN-TBS Cs) in the bloodstream of the patient and their eventual removal by means of a 'magnetic dialyzer'. Presented here is an in vitro investigation on the biocompatibility of bare Fe(3)O(4) FNs and Fe(3)O(4)-bovine serum albumin Cs with blood cells, namely red blood cells (RBCs), white blood cells (WBCs) and platelets (Plts). Atomic force microscopy (AFM) and optical microscopy (OM) enabled the examination of blood cells at the nanometer and micrometer level, respectively. The observations made on FN- and C-maturated blood samples are contrasted to those obtained on FN- and C-free reference blood samples subjected to exactly the same maturation procedure. Qualitatively, both AFM and OM revealed no changes in the overall shape of RBCs, WBCs and Plts. Incidents where bare FNs or Cs were bound onto the surface of RBCs or internalized by WBCs were very rare. Detailed examination by means of OM proved that impaired coagulation of Plts is not initiated/promoted either by FNs or Cs. Quantitatively, the statistical analysis of the obtained AFM images from RBC surfaces clearly revealed that the mean surface roughness of RBCs maturated with bare FNs or Cs was identical to the one of reference RBCs.
ABSTRACT
By using nuclear magnetic resonance techniques we show that for T<30 K the La0.875Sr0.125MnO3 compound displays a nonuniform charge distribution, comprised of two interconnected Mn ion subsystems with different spin, orbital, and charge couplings. The NMR results agree very well with the two spin wave stiffness constants observed at small q values in the spin wave dispersion curves [Phys. Rev. B 67, 214430 (2003)]. This picture is probably related to a yet undetermined charge and orbital superstructure occurring in the ferromagnetic insulating state of the La0.875Sr0.125MnO3 compound.
ABSTRACT
Electron spin resonance (ESR) has been applied to investigate the magnetic heterogeneity in electron doped La(1-x)Ca(x)MnO(3) (0.80≤x≤0.95). A low field ferromagnetic resonance (FMR) mode is observed for lightly doped compounds (x = 0.90,0.95), signifying the formation of ferromagnetic (FM) spin clusters within the antiferromagnetic G-type AFM phase. The anomalous temperature variations of the resonance field, linewidth and FMR intensity, as well as the observation of thermal cycling effects below T(C), emphasize the non-trivial dynamics of the FM phase, which is attributed to the temperature dependent size evolution of the underlying spin clusters towards canted AFM and FM domains. For heavier electron doping (x = 0.80,0.85), distinct AFM behaviour is evinced in the vicinity of T(N) in the monoclinic C-type AFM phase, characterized by the absence of critical relaxation. Additional weak FMR lines are observed for x = 0.80 and 0.85, whereas a narrow superparamagnetic-like signal is detected for x = 0.95.
ABSTRACT
55Mn and 139La NMR measurements on a high quality single crystal of ferromagnetic (FM) La0.80Ca0.20MnO3 demonstrate the formation of localized Mn(3+,4+) states below 70 K, accompanied by a strong cooling-rate dependent increase of certain FM neutron Bragg peaks. (55,139)(1/T(1)) spin-lattice and (139)(1/T(2)) spin-spin relaxation rates are strongly enhanced on approaching this temperature from below, signaling a genuine phase transition at T(tr) approximately 70 K. The disappearance of the FM metallic signal by applying a weak external magnetic field, the different NMR radio-frequency enhancement of the FM metallic and insulating states, and the observed finite size scaling of T(tr) with Ca (hole) doping, as observed in powder La(1-x)CaxMnO3 samples, are suggestive of freezing into an inhomogeneous FM insulating and orbitally ordered state embodying "metallic" hole-rich walls.
ABSTRACT
We have studied the phase diagram of the MgB(2) superconductor using a single crystal for the H parallel c-axis. For the first time we report the existence of peak effect in the screening current in the MgB(2) for the H parallel c-axis. In the magnetic field regime 10
ABSTRACT
55Mn NMR line shape measurements in La1-xCaxMnO3 for 0.20< or =x< or =0.50 provide experimental evidence about the existence of two distinct regions in the T-x magnetic phase diagram, where the homogeneous ferromagnetic (FM) metallic state is separated into FM metallic and FM insulating regions. These results are in agreement with recent theoretical predictions, which reveal a novel electronic phase separation in two FM states, providing orbital ordering and Jahn-Teller phonons are taken into consideration.
ABSTRACT
The crystal and magnetic structures of the perovskite YBaCuFeO5+δhave been studied in the temperature rangeT = 4.2-300 K by powder neutron diffraction. In addition to the antiferromagnetic ordering transition atTN = 442 K, a commensurate-incommensurate magnetic transition is detected atTN' = 190 K. Below this temperature, two sets of satellite peaks surround the (1/2,1/2,1/2) magnetic peak atd â¼ Å, collapsing into a single set of satellites below 155 K. Polarization analysis has been performed to confirm the magnetic nature of the (1/2,1/2,1/2)±satellites.