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1.
Clin Rheumatol ; 14(4): 407-12, 1995 Jul.
Article in English | MEDLINE | ID: mdl-7586976

ABSTRACT

Forty-three female patients with systemic sclerosis divided into subgroups based on the extent of skin involvement and the presence of calcinosis, and 50 sex and age-matched healthy controls were investigated for bone mineral density (BMD) on the basis of radial (dual photon absorptiometry, Osteograph, NIM), lumbar, and total body measurements (dual energy X-ray absorptiometry, Lunar DPX, Lunar Corp.), and for parameters of calcium metabolism. The patients showed a lower BMD (mean +/- SD; mg/cm2) than the controls at the radial (313 +/- 69 vs 347 +/- 73; p < 0.005), lumbar (974 +/- 143 vs 1081 +/- 154; p < 0.005), and total body (997 +/- 82 vs 1075 +/- 109; p < 0.05) determinations. The patients with the diffuse form of skin involvement had lower values than those with the limited form. There was a negative correlation between BMD and the duration of the disease. The presence of calcinosis was not found to have any effect on BMD. Calcium metabolism was found to be normal in each subgroup. It may be concluded that generalized osteoporosis is a feature of systemic sclerosis, with and without calcinosis. The extent and duration of the disease may play a role in determining bone loss.


Subject(s)
Bone Density , Calcinosis/physiopathology , Calcium/metabolism , Scleroderma, Systemic/physiopathology , Absorptiometry, Photon , Adult , Age Factors , Aged , Calcinosis/complications , Calcinosis/metabolism , Female , Humans , Middle Aged , Osteoporosis, Postmenopausal/complications , Osteoporosis, Postmenopausal/metabolism , Osteoporosis, Postmenopausal/physiopathology , Scleroderma, Systemic/complications , Scleroderma, Systemic/metabolism
2.
Article in English | MEDLINE | ID: mdl-8078672

ABSTRACT

In order to evaluate the nature and association of audiovestibular disturbances and systemic sclerosis (SSC), 37 unselected SSC patients were studied with a detailed audiological and vestibular examination since November, 1987. Pure-tone audiometry, speech audiometry, impedance audiometry, brainstem response audiometry and vestibular function using electronystagmographic recording were performed. We found a rather frequent audiovestibular involvement (41%). A hearing loss was found in 14 SSC patients; hearing loss was sensorineural in 10 cases and mixed in 4 cases. The latter revealed a finding similar to tympanosclerosis. Four patients showed altered vestibular test values and only one of these had normal hearing. Sensorineural deafness was the more frequent pathological finding and in all cases the site of lesion was cochlear. SSC appears to be directly responsible for audiovestibular damage, since in 12 out of 15 patients with such involvement, no other apparent cause could be revealed. SSC may be included among the autoimmune diseases which may cause audiovestibular disturbances.


Subject(s)
Hearing , Postural Balance , Scleroderma, Systemic/physiopathology , Acoustic Impedance Tests , Adult , Aged , Audiometry, Evoked Response , Audiometry, Pure-Tone , Audiometry, Speech , Deafness/etiology , Electronystagmography , Female , Humans , Male , Middle Aged , Scleroderma, Systemic/complications , Vestibule, Labyrinth/physiopathology
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