1.
Vet Hum Toxicol
; 35(1): 45-8, 1993 Feb.
Article
in English
| MEDLINE
| ID: mdl-8434456
ABSTRACT
We undertook a retrospective review of all the liver biopsies done by us between 1985 and 1990 for the purpose of monitoring methotrexate (MTX)-induced hepatotoxicity in rheumatoid arthritis (RA) patients. A total of 29 biopsies were done in 25 patients. The mean total cumulative dose of MTX was 1585 +/- 348 (SD) mg. Average duration of MTX therapy was 31 +/- 9.8 mo (SD). Liver biopsy after accumulating 900 mg and 1200 mg MTX, respectively, in 2 obese diabetic patients showed evidence of cirrhosis. Obese diabetics may represent a subgroup of RA patients at risk for developing MTX-induced hepatotoxicity.
Subject(s)
Arthritis, Rheumatoid/drug therapy , Liver Cirrhosis/chemically induced , Methotrexate/adverse effects , Adult , Aged , Arthritis, Rheumatoid/pathology , Biopsy , Diabetes Mellitus, Type 2/complications , Female , Humans , Liver Cirrhosis/pathology , Long-Term Care , Male , Methotrexate/therapeutic use , Middle Aged , Retrospective Studies
2.
N Engl J Med
; 308(17): 1012-4, 1983 Apr 28.
Article
in English
| MEDLINE
| ID: mdl-6403861
Subject(s)
Exostoses/chemically induced , Ichthyosis/drug therapy , Tretinoin/adverse effects , Adolescent , Adult , Female , Humans , Isotretinoin , Long-Term Care , Male , Tretinoin/toxicity
3.
4.
JAMA
; 239(10): 959, 1978 Mar 06.
Article
in English
| MEDLINE
| ID: mdl-304900
5.
JAMA
; 236(7): 819, 1976 Aug 16.
Article
in English
| MEDLINE
| ID: mdl-947250
