ABSTRACT
OBJECTIVE: To evaluate the usefulness of uterine artery Doppler in the prediction of outcome in patients with late-onset preeclampsia. STUDY DESIGN: Patients with late-onset preeclampsia underwent Doppler interrogation of the uterine arteries. Patients with abnormal uterine artery Doppler were compared with those who had a normal uterine artery Doppler. RESULTS: Ninety-nine patients were included in the study group. Abnormal uterine artery Doppler group presented significantly lower gestational age at admission (36.1 +/- 2.1 weeks vs 37.2 +/- 1.9 weeks; P < .005), lower gestational age at delivery (36.5 +/- 1.9 weeks vs 37.7 +/- 1.7 weeks; P < .005), lower birthweight (2429 +/- 590 g vs 3013 +/- 597 g; P < .0001), and a higher admission rate to neonatal intensive care unit (17/51 vs 6/48; odds ratio, 3.5; 95% confidence interval, 1.2-9.5). No significant difference in the occurrence of maternal complications (10/51 vs 6/48; odds ratio, 1.7; 95% confidence interval, 0.5-4.9) was registered. CONCLUSION: Women with late-onset preeclampsia show a higher risk of perinatal complications if uterine resistance is increased although maternal outcome does not seem to be related to Doppler findings.
Subject(s)
Pre-Eclampsia/diagnostic imaging , Pregnancy Outcome , Ultrasonography, Doppler , Ultrasonography, Prenatal , Uterus/blood supply , Adult , Anthracenes , Arteries/diagnostic imaging , Female , Humans , Pre-Eclampsia/physiopathology , Pregnancy , Pregnancy Trimester, Third , Prognosis , Regional Blood FlowABSTRACT
INTRODUCTION: The role of (18)F-FDG PET in the management of gynaecologic malignancies remains unclear mainly due to the failure of clinicians to appreciate the significance of this imaging tool. However, this under utilisation is being actively re-addressed with a large number of reviews and studies, particularly in the last few years. METHODS AND RESULTS: PET has been shown to have high sensitivity and specificity in the evaluation of relapse and nodal disease in cervical cancer, while other uses such as staging and monitoring response to therapies being under further investigation. Similarly, promising results have been published in the use of PET in patients affected by endometrial cancer and uterine sarcomas for detecting lymph nodes metastasis and recurrent disease. In ovarian cancer, PET appears to have a great potential in staging and assessment of disease relapse. An important utility of PET in gynaecologic tumours, which is shared with a large number of other malignancies, is its value in positively changing the patients' management. CONCLUSION: The surge in studies using PET in gynaecological malignancies is in its early stages, and further studies are required to optimise the role of PET in these conditions.
Subject(s)
Carcinoma/diagnostic imaging , Genital Neoplasms, Female/diagnostic imaging , Positron-Emission Tomography , Sarcoma/diagnostic imaging , Female , Fluorodeoxyglucose F18 , Humans , Sensitivity and SpecificityABSTRACT
Nas últimas décadas foram introduzidos na dieta produtos de menor valor calórico, como adoçantes dietéticos. O aspartame está entre os adoçantes mais utilizados mundialmente, e seu consumo continua crescendo. Este adoçante tem semelhanças com drogas anti-inflamatórias näo esteroidais e pode vir a ser utilizado no tratamento da osteoartrite, trombose e crises febris. É ainda usado no tratamento da obesidade e diabetes. No entanto, o aspartame vem sendo associado a câncer de cérebro, enxaquecas, reaçöes alérgicas e mudanças comportamentais. Os metabólitos do aspartame também causam preocupaçäo, especialmente no caso de fenilcetonúricos. Ainda existe polêmica em torno do uso deste adoçante e de seus possíveis efeitos.
