1.
Tsitol Genet
; 45(1): 68-79, 2011.
Article
in Russian
| MEDLINE
| ID: mdl-21446161
ABSTRACT
Mutagenic factors of biological origin by the example of carbohydrate-binding proteins are observed. An attempt of summarizing the existing data concerning participation of exogenous macromolecules in mutagenic process is made. The mechanisms of the influence of exogenous macromolecules on mutagenesis, proliferation, and surviving of mammalian cells are discussed.
Subject(s)
Lectins , Mutagenesis , Adaptation, Biological , Animals , Humans , Lectins/genetics , Lectins/pharmacology , Lectins/physiology , Mercaptopurine/pharmacology , Mutagenesis/drug effects , Mutagenesis/genetics
2.
Ukr Biokhim Zh (1999)
; 80(6): 60-5, 2008.
Article
in Russian
| MEDLINE
| ID: mdl-19351058
ABSTRACT
The influence of plant lectins on primary DNA damage repair and on expression of repair enzyme alkylguanine-DNA alkyltransferase (MGMT) in mammalian cells in vitro has been investigated. Those lectins have been shown to modify DNA damage repair process, and to induce the MGMT expression increasing its level in the used model system.
