[The risk groups of infection with hepatitis С virus in conditionally healthy population of the Belgorod oblast].

The purpose of study was to establish risk group on hepatitis C in conditionally healthy population of the Belgorod oblast. Total 2025 conditionally healthy inhabitants aged between 1 and 99 were surveyed and serum samples from them were tested. There were eight age groups: 1-14 years (12.3%), 15-19 years (13.1%), 20-29 years (12.7%), 30-39 years (12.8%), 40-49 years (12.8%), 50-59 years (11.8%), 60-69 years (8.6%) and over 70 years of age (15.7%). Overall, 44.6% of the examined persons were male. 41.3% (ranging from 6.5 to 72.1%) of respondents reported surgery in their anamnesis, 5.1% (ranging from 0.8 to 12.6%) had blood/blood products transfusion, 10.3% (ranging from 1.7 to 57.9%) ear/nose piercing and 2.96% (ranging from 0.8 to 6.6%) tattoos. There were no people who injected drugs. The piercing was significantly higher in age groups 15-19 years and 20-29 years than other age groups (p-value<0.05). The tattoos were significantly higher in group of 70 years and older than in age groups 15-19 years, 30-39 years and 40-49 years (p-value<0.05). Anti-HCV antibodies were detected using third-generation enzyme-linked immunosorbent assay ("IFA-ANTI-HCV", Nizhny Novgorod). The HCV RNA was tested with RT-PCR. The Anti-HCV was detected in 22 persons (1.1%), 77.3% out of them were older than 53 year and they were born prior to 1965. The Anti-HCV were significantly higher for the people over 70 years of age than in the age groups of 1-14 years, 15-19 years, 30-39 years and 40-49 years (p-value<0.05). The 2.65% of the examined persons were older 53 years had anti-HCV. Only 0.36% of anti-HCV were found in the young age groups of the examined persons who were born after 1965, the percentage was significantly lower than in older age groups (p-value<0.05). The 16 people had RNA-HCV and 87.5% persons were born in or before 1965. There was one person with genotype 3a (age group 30-39 years), 15 persons with genotype 1b (fourteen out of them were older 53 years and one person was in the age group 20-29 years. The study established that risk age group are inhabitants born before 1965 in Belgorod region. It can be taken into account in regional hepatitis С screening programs.

Mechanism of inhibiting effect of biologically active compounds on the active forms of oxygen reduction.

The impulse voltammetry methods with recording short-living radical-natured products of the reduction (in particular, hydroxyl radicals) are used to study the process of oxygen reduction steps. A possibility to study mechanisms of antioxidative action of biologically active compounds (BAC) through studying their influence on the separate steps of oxygen reduction (initial molecular oxygen, radical particles and peroxides) is shown. It provides a possibility for the purposeful search of BAC capable to affect certain steps of chain oxidation in biosystems.

[Enterosorption in the combined treatment of patients with viral hepatitis]. / Enterosorbtsiia v kompleksnom lechenii bol'nykh virusnymi gepatitami.

The authors studied the efficacy of using USSR-made adsorbent "Enterosgel" in the complex treatment of viral hepatitis. A scheme of employment of the drug is described. Recommendations on the doses and duration of treatment are given. It was established that the efficacy of "Enterosgel" treatment was optimal in patients with intoxication syndrome due to hepatic insufficiency, cholestasis with marked skin pruritus and allergic manifestations. Use of the named drug permits to restrict the employment of other agents that effected favourably the course and outcome of viral hepatitis.