ABSTRACT
Three unrelated, sporadic patients with muscle coenzyme Q10 (CoQ10) deficiency presented at 32, 29, and 6 years of age with proximal muscle weakness and elevated serum creatine kinase (CK) and lactate levels, but without myoglobinuria, ataxia, or seizures. Muscle biopsy showed lipid storage myopathy, combined deficiency of respiratory chain complexes I and III, and CoQ10 levels below 50% of normal. Oral high-dose CoQ10 supplementation improved muscle strength dramatically and normalized serum CK.
Subject(s)
Metabolism, Inborn Errors/complications , Muscle, Skeletal/enzymology , Muscular Diseases/etiology , Ubiquinone/analogs & derivatives , Adult , Coenzymes , Creatine Kinase/blood , Delivery, Obstetric , Disease Progression , Electron Transport Complex I/deficiency , Electron Transport Complex III/deficiency , Female , Humans , Lactic Acid/blood , Lipid Metabolism , Male , Muscle Weakness/etiology , Muscle, Skeletal/metabolism , Muscular Diseases/drug therapy , Muscular Diseases/pathology , Muscular Diseases/physiopathology , Pregnancy , Pregnancy Complications/etiology , Pregnancy Complications/physiopathology , Ubiquinone/deficiency , Ubiquinone/therapeutic useABSTRACT
Factor analyses of health complaints in groups with different length of shiftwork exposure show that the structure of these complaints changes with increasing shift experience, indicating the emergence of a shift-specific pattern of health complaints. After about 15 years of shiftwork, complaints related to disturbances of circadian-controlled functions can be found in the first factor whereas other complaints have their dominant loadings on a separate factor, representing general, non-shift-specific impairments. The results indicate that in this way shift-specific components of health impairment can be separated from other non-shift related components.
Subject(s)
Circadian Rhythm/physiology , Occupational Health/statistics & numerical data , Police , Work Schedule Tolerance/physiology , Adult , Factor Analysis, Statistical , Female , Germany, West , Health Behavior , Humans , Male , Middle Aged , Sleep , Time Factors , Work Schedule Tolerance/psychologyABSTRACT
3 1/2 years after two operations and radiation therapy of a biparietally, parasagittaly localised grade III oligoastrocytoma, a 34-year-old patient developed symptoms of the spinal cord. By performing magnetic resonance tomography and laminectomy, multiple metastases of the anaplastic part of the primary tumour could be identified. Spinal seedings of a tumour of this grading are even rarer than those sporadically reported on corresponding complications of a multiform glioblastoma. Risk factors for the development of such a complication are youth of the patient, primary site of the tumour near the midline and anaplastic parts of the tumour in adults. If such a constellation exists, one should definitely consider the possibility of a spinal seeding in a grade III glioma, especially because in these younger patients thus would be of greater relevance for therapy than in patients with multiform glioblastoma.
