1.
Arch Pharm (Weinheim)
; 333(7): 231-40, 2000 Jul.
Article
in English
| MEDLINE
| ID: mdl-10965598
ABSTRACT
Starting from substituted 3,6-dichloropyridazine-4-carboxamides (2, 3) tri- and tetracyclic compounds (4, 5) could be smoothly prepared. Structural modifications of interest with regard to biological activity were performed by N-alkylation and reductive dehalogenation. The new substituted heterocyclic compounds were screened as antimycobacterial agents; the influence of the substitution pattern on activity is discussed.