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J Hum Nutr Diet ; 27(5): 468-78, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24138546

ABSTRACT

BACKGROUND: Low adiponectin levels are discussed as risk factor for cardiovascular events. This is of special importance in individuals with type 2 diabetes (T2DM) because they are at higher risk for cardiovascular diseases. The present study aimed to investigate the effect of two plant oils rich in polyunsaturated fatty acids (PUFA), with different content of omega-3 fatty acids, on adiponectin levels, glucose and lipid metabolism in T2DM individuals treated either with insulin or oral anti-diabetics (OAD). METHODS: Ninety-two subjects with T2DM [34 treated with insulin (T2DM-Ins) and 58 treated with OAD (T2DM-OAD)] participated in this randomised, double-blind, parallel intervention study. Individuals received either 9 g of nut oil (n-3:n-6 ratio: 1.3 : 6.1) or mixed oil (n-3:n-6 ratio: 0.6 : 5.7) per day for 10 weeks. The fatty acid profile, tocopherol, adiponectin levels and parameters regarding glucose and lipid metabolism were assessed at baseline, during and after the intervention. RESULTS: Compliance was confirmed by significant increases in γ-tocopherol and PUFA in both oil groups. An increase in adiponectin levels in T2DM-Ins participants (+6.84% in nut oil and +4.47% in mixed oil group after 10 weeks compared to baseline) was observed, albeit not significantly different from T2DM-OAD individuals (P = 0.051). Lipid and glucose metabolism were not affected by the intervention. CONCLUSIONS: The present study provides evidence that a small and easy change in dietary behaviour towards better fat quality moderately increases adiponectin levels in T2DM-Ins subjects, independently of the administered plant oil.


Subject(s)
Adiponectin/blood , Diabetes Mellitus, Type 2/diet therapy , Diet, Diabetic , Dietary Fats, Unsaturated/therapeutic use , Hyperglycemia/prevention & control , Lipids/blood , Plant Oils/therapeutic use , Aged , Austria/epidemiology , Cardiovascular Diseases/complications , Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/prevention & control , Combined Modality Therapy/adverse effects , Diabetes Mellitus, Type 2/blood , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/drug therapy , Diabetic Angiopathies/complications , Diabetic Angiopathies/epidemiology , Diabetic Angiopathies/prevention & control , Diabetic Cardiomyopathies/complications , Diabetic Cardiomyopathies/epidemiology , Diabetic Cardiomyopathies/prevention & control , Dietary Fats, Unsaturated/adverse effects , Double-Blind Method , Fatty Acids, Omega-3/adverse effects , Fatty Acids, Omega-3/therapeutic use , Fatty Acids, Omega-6/adverse effects , Fatty Acids, Omega-6/therapeutic use , Female , Humans , Hypoglycemic Agents/therapeutic use , Male , Middle Aged , Plant Oils/adverse effects , Risk Factors
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