ABSTRACT
Immunohistochemical assay with double label and confocal laser scanning microscopy showed that innate immunity receptor TLR4 is expressed predominantly in neurons of the intestinal Auerbach (myenteric) plexus, while vanilloid nociceptive receptor TRPV1 is expressed by neurons of Meissner (submucous) plexus. Immunohistochemical analysis with triple labeling revealed coexpression of TLR4 and TRPV1 in enteric neurons of rat colon. The results attest to a possibility of functional interaction between Toll-like and vanilloid receptors in the neuron level.
Subject(s)
Colon/innervation , Myenteric Plexus/metabolism , Nociceptors/metabolism , Receptors, Pattern Recognition/metabolism , Submucous Plexus/metabolism , TRPV Cation Channels/metabolism , Toll-Like Receptor 4/metabolism , Animals , Colon/metabolism , Immunohistochemistry , Male , Microscopy, Confocal , Rats , Rats, Sprague-Dawley , Statistics, NonparametricSubject(s)
Appendectomy/mortality , Appendicitis/surgery , Postoperative Complications/epidemiology , Acute Disease , Adolescent , Adult , Aged , Appendicitis/mortality , Child , Female , Humans , Male , Middle Aged , USSRABSTRACT
An analysis of 11127 appendectomies has been made, among which carcinoid of the appendicular process was revealed in 8 cases. The carcinoid was diagnosed histologically. It is the authors' opinion that determination of the serotonin level in blood and 5-hydroxy-indol acetic acid in urine would permit to judge the activity of the carcinoid process. In case of progressing carcinoid a pararectal incision with a revision of the abdominal organs is recommended. Patients operated upon should be under medical observation.
