Factores precipitantes de crisis de migraña en pacientes atendidos en consultas de neurología. Estudio FACTOR / Precipitating factors of migraine attacks in patients attended in neurology services. The FACTOR study

Introducción. Los pacientes con migraña refieren con frecuencia factores o circunstancias que precipitan o desencadenansus crisis. A pesar de ello, son muy escasos los estudios realizados al efecto. Objetivo. Explorar los factores precipitantes de crisis de migraña en nuestro medio, así como su posible relación con laintensidad de las crisis o la repercusión global de la migraña. Pacientes y métodos. Estudio epidemiológico, transversal y multicéntrico realizado en consultas de neurología. Se recogierondatos sociodemográficos y clínicos, así como los factores precipitantes identificados de un listado cerrado. Se utilizaron el cuestionario de discapacidad específico para migraña -Headache Impact Test (HIT-6)- y la medida del número de días equivalentes a días de trabajo perdidos. Resultados. Se reclutaron 817 pacientes (72,5% mujeres; edad media: 34,6 ± 10,3 años). El 70,5% de los pacientes tenía un grado de discapacidad grave según el HIT-6. La media mensual de días equivalentes a días de trabajo perdidos fue de 2,1 ± 2,5. Un 96,6% de los pacientes identificó algún factor precipitante de crisis, siendo los más frecuentemente comunicadoslos hormonales (75,2%), el estrés (70,9%) y los relacionados con las alteraciones en el patrón de sueño (68,4%). Conclusiones. El estudio FACTOR confirma que la mayoría de pacientes con migraña identifica alguna circunstancia precipitantede sus crisis. El control o evitación de estos factores, en los casos en que sea posible, debe formar parte del programa de educación del paciente con migraña (AU)

Introduction. Patients with migraine often report factors or circumstances that precipitate or trigger their attacks. Yet fewstudies have been conducted to examine this matter. Aim. To explore the factors that precipitate migraine in our setting, as well is their possible relation with the intensity ofthe attacks or the overall repercussion of migraine.Patients and methods. An epidemiological, cross-sectional, multi-centre study was conducted in neurology consultation services. Sociodemographic and clinical data were collected and the precipitating factors were identified from a closed list. The specific migraine disability questionnaire -Headache Impact Test (HIT-6)- and the measurement of the number of lost workday equivalents were used in the study.Results. Altogether 817 patients were recruited (72.5% females, mean age: 34.6 ± 10.3 years). A total of 70.5% of the patients had severe disability according to the HIT-6. The mean monthly number of lost workday equivalents was 2.1 ± 2.5. A total of 96.6% of the patients identified some precipitating factor for the attacks, the most commonly reported being hormonal (75.2%), stress (70.9%) and those related with disorders affecting sleep patterns (68.4%). Conclusions. The FACTOR study confirms that most patients with migraine identify some circumstance that precipitatestheir attacks. Controlling or avoiding these factors, whenever possible, must be part of the programme of education received by patients suffering from migraine (AU)

[Precipitating factors of migraine attacks in patients attended in neurology services. The FACTOR study]. / Factores precipitantes de crisis de migraña en pacientes atendidos en consultas de neurología. Estudio FACTOR.

INTRODUCTION: Patients with migraine often report factors or circumstances that precipitate or trigger their attacks. Yet few studies have been conducted to examine this matter. AIM: To explore the factors that precipitate migraine in our setting, as well is their possible relation with the intensity of the attacks or the overall repercussion of migraine. PATIENTS AND METHODS: An epidemiological, cross-sectional, multi-centre study was conducted in neurology consultation services. Sociodemographic and clinical data were collected and the precipitating factors were identified from a closed list. The specific migraine disability questionnaire -Headache Impact Test (HIT-6)- and the measurement of the number of lost workday equivalents were used in the study. RESULTS: Altogether 817 patients were recruited (72.5% females, mean age: 34.6 ± 10.3 years). A total of 70.5% of the patients had severe disability according to the HIT-6. The mean monthly number of lost workday equivalents was 2.1 ± 2.5. A total of 96.6% of the patients identified some precipitating factor for the attacks, the most commonly reported being hormonal (75.2%), stress (70.9%) and those related with disorders affecting sleep patterns (68.4%). CONCLUSIONS: The FACTOR study confirms that most patients with migraine identify some circumstance that precipitates their attacks. Controlling or avoiding these factors, whenever possible, must be part of the programme of education received by patients suffering from migraine.

Acceptability of lansoprazole orally disintegrating tablets in patients with gastro-oesophageal reflux disease : ACEPTO study.

OBJECTIVE: To assess the acceptability of lansoprazole orally disintegrating tablets (LODT) in patients with gastro-oesophageal reflux disease (GORD). METHODS: A multicentre, observational, cross-sectional study of patients diagnosed with GORD aged > or =18 years under the care of 272 gastroenterologists. Acceptability was determined by global patient assessment whereby the drug's organoleptic characteristics and properties were evaluated by a self-administered 11-item ad hoc questionnaire with a 5-point Likert-type scale. RESULTS: A total of 734 patients (mean age 49.6 years [SD = 15.2]) with GORD who had been prescribed LODT > or =14 days prior to inclusion in the study were evaluable for the main endpoint. Of these, 51.1% were men. Most patients (80.7%) had been treated with doses of LODT 30mg/day for an average of 52.7 days (SD = 59.3). Overall, 93.6% of patients rated LODT treatment as 'very acceptable' or ''acceptable'. The degree of acceptability was associated with the perception that the formulation helps treatment compliance (p < 0.001). The drug's properties were rated as follows: size 'neither large nor small' (70.0%); flavour 'very pleasant' or 'pleasant' (75.2%); intensity of flavour 'neither strong nor mild', 'mild' or 'very mild' (86.1%); no 'sandy sensation' (53.4%); speed of dissolving 'fast' or 'very fast' (80.2%); use of tablets 'very easy' or 'easy' (92.4%) and use of tablets 'very convenient' or 'convenient' (91.0%). Three adverse reactions, none of them serious, were reported in three patients (0.4%). CONCLUSIONS: LODT were well accepted by patients with GORD. Patients reported that this formulation improved compliance with therapy. Tolerability was excellent.