ABSTRACT
Lichen simplex chronicus (LSC) of the anal region is characterized by massive pruritus, constant itching and a chronic course. Histology is notable for a pseudoepitheliomatous hyperplasia. Correct diagnosis as well as therapy of anal LSC sometimes is difficult. Differential diagnostic considerations include verrucous lichen planus and squamous cell carcinoma. We present three cases and then summarize pathogenesis, diagnostics, differential diagnoses and therapeutic options for lichen simplex chronicus of the anal region.
Subject(s)
Anal Canal/pathology , Intestinal Diseases/diagnosis , Intestinal Diseases/therapy , Neurodermatitis/diagnosis , Neurodermatitis/therapy , Aged , Anus Neoplasms/diagnosis , Anus Neoplasms/therapy , Diagnosis, Differential , Female , Humans , Male , Middle AgedABSTRACT
Diagnosis and treatment of syphilis are challenging because of the condition's diverse clinical symptoms, histopathological variance, and the lack of definite tests for treatment follow-up. We report a case of secondary pustular-ulcerative malignant syphilis with ocular involvement in a human immunodeficiency virus-infected patient. It was striking to find that ulcerative lesions can be highly organism depleted.
