Long-term impact of familismo and ethnic identity on latinx college student drinking and high-risk consequences.

Familismo, ethnic pride, and ethnic shame were examined as longitudinal predictors of Latinx college student alcohol use and high-risk alcohol-related consequences. Latinx students completed measures during the fall of their first (T1), second (T2), and fourth (T4) year of college. T1 familismo was positively associated with T2 ethnic pride and negatively associated with T2 ethnic shame. T2 ethnic pride was negatively associated with T4 drinking, while T2 ethnic shame was positively associated with T4 drinking. T4 drinking was positively associated with T4 consequences. Results suggest that Latinx ethnic pride and ethnic shame during the second-year of college act as mediators between first-year familismo and fourth-year drinking and consequences.

Indigenous peoples and inclusion in clinical and genomic research: Understanding the history and navigating contemporary engagement.

Despite significant improvements in pediatric cancer survival outcomes, there remain glaring disparities in under-represented racial and ethnic groups that warrant mitigation by the scientific and clinical community. To address and work towards eliminating such disparities, the Pacific Pediatric Neuro-Oncology Consortium (PNOC) and Children's Brain Tumor Network (CBTN) established a Diversity, Equity, and Inclusion (DEI) working group in 2020. The DEI working group is dedicated to improving access to care for all pediatric patients with central nervous system (CNS) tumors, broadening diversity within the research community, and providing sustainable data-driven solutions. To this end, the DEI working group aims to coordinate regular educational sessions centered on critical DEI topics in pediatric research and clinical care of pediatric patients, with a focus on pediatric neuro-oncology. In April 2022, the group led a moderated panel of experts on Indigenous Peoples' rights and participation in clinical research activities. The following paper serves to provide the scientific community a perspective on how to prioritize the inclusion of Indigenous Peoples in research with cultural sensitivity and with the intent of improving not only representation, but patient outcomes regardless of patient race, ethnicity, or socioeconomic background.

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for > 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors.

Motivations to combine alcohol and nicotine in college students: A validation of the Alcohol and Nicotine Motives Scale.

INTRODUCTION: Research on combining alcohol and nicotine (ALCNIC) has shown this risky behavior results in significantly more consequences than using either alcohol or nicotine alone. No measures currently exist to assess ALCNIC motives limiting intervention and prevention efforts. The present study developed a psychometrically sound and multidimensional measure of ALCNIC motives (the ANMS). METHODS: An initial item pool of ALCNIC items was developed from literature on college student drinking, focus groups, and individual interviews. Study 1 involved students from a northeastern university who completed an online survey on the ALCNIC items (N = 55; 57.1% female; Mage = 20.3). Analysis focused on reliability (exploratory factor analysis). Study 2 involved a cross-validation national sample of college students (N = 336; 49.7% female; Mage = 21.2) completing the same survey items. Confirmatory factor analysis, criterion-related validity (ALCNIC/weekend drinking), and discriminant validity (social desirability) were assessed using structural equation modeling. RESULTS: Results across two studies revealed three factors to engage in ALCNIC: antagonistic (party longer), synergistic (enhanced effects), and social (peer pressure); and one factor to avoid ALCNIC: negative effects (feeling anxious) (all alphas > 0.7). In study 2, criterion-related validity revealed that synergistic motives were significantly positively associated with ALCNIC use; and negative effects motives were significantly negatively associated with ALCNIC use. Discriminant validity showed ALCNIC subscales were not significantly associated with social desirability (except social). CONCLUSIONS: The study developed a reliable and valid measure of motives for ALCNIC use. Results were robust to cross-validation across two samples of college students. These measures provide targets for intervention and prevention efforts.