[Morphological and functional characteristics of myocardium in patients with cardiac insufficiency and its pharmacologic correction]. / Morfofunktsionalnaia kharakteristika miokarda u liudei pri serdechnoi nedostatochnosti i eë farmakologicheskaia korrektsiia.

Contractile properties and micromorphology of the human myocardium were studied in bioptates of the right auricula at the heart failure and its pharmacological correction. It is shown that the chronoinotropic dependence of trabecular muscles of the human heart is a negative one. Vegetation of the connective tissue in the myocardium begins at the stage of development of its hypertrophy. Digoxin in combination with diuretics improves contractile properties and decreases expressiveness of dystrophic changes in myocardiocytes. Combination of the mentioned means with a blocker of the renin-angiotensin system, kapothenum in particular, not only improves the state of the contractile apparatus of the heart, but also causes a reverse development of the hyperplasive connective tissue.

[The effect of polyfunctional macroheterocycles on the rhythmic and contractile activity of the myocardium in animals]. / Vliianie polifunktsional'nykh makrogeterotsiklov na ritmicheskuiu i sokratitel'nuiu aktivnost' miokarda zhivotnykh.

The effect of the polyfunctional macroheterocycles on the rhythmic and contractile activity of the rat myocardium was found to depend on their concentration. A two-phasic effect upon contractility of the papillary muscles was revealed: a short-term (up to 20 sec) positive inotropic effect followed by a stable depression. The most active drug of this class, dicyclohexano-18-crown-6, prevented the positive inotropic action of classic stimulants (catecholamines and strophantin) upon the contractile function of the heart.

[The effect of various regimens of postischemic reperfusion on the recovery of the functional activity of the myocardium]. / Vliianie razlichnykh rezhimov postishemicheskoi reperfuzii na vosstanovlenie funktsional'noi aktivnosti miokarda.

Postischemic reperfusion of isolated canine hearts after 30 min of 80-85% blood supply limitation was performed during 60 min with perfusion pressure raised to 135 mm Hg instead of 100 mm Hg in the control. The data obtained suggest that myocardial blood supply increased by reperfusion affected the restoration of cardiac function. The optimal result of the reperfusion was achieved in the condition of decreased perfusion pressure in the early phase of reperfusion combined with the Inosie-F infusion.

[Effect of retabolil, biosed and vitreous body on reparative processes in the heart of rats with experimental myocardial infarction]. / Vliianie retabolila, bioseda i steklovidnogo tela na reparativnye protsessy v serdtse krys s éksperimental'nym infarktom miokarda.

Influence of retabolilum, biossedum and corpus vitreum on the inflammation and reparation in the rat heart with experimental infarction has been investigated. It is shown that retabolilum has the most pronounced reparation effect. At the same time biossedum has a slight effect on the reparative processes and corpus vitreum does not influence it al all. It is also found that the most pronounced action of retabolilum has been observed by the 12th day of infarction.

[Evaluation of obzidan efficacy in patients with unstable stenocardia]. / Otsenka éffektivnosti obzidana u bol'nykh nestabil'noi stenokardiei.

Altogether 75 patients (males aged 31 to 67 years) with unstable angina pectoris were subjected to transcutaneous pacing to measure the coronary reserve level before and after administration of obsidan (propranolol) in a dose of 40 mg. The area and depth of ischemia were found to be noticeably decreased, which was appraised according to 35 precordial leads on the ECG regardless of the unchanged "double product". It is concluded that not only the reduction of the heart rate and afterload but also their effect on the functional factors of angina pectoris are implicated in the mechanism of the anti-ischemic action of the beta-blockers.